Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality

• Published in: Translational Research Vol. 205; pp. 17 - 32
• Main Authors: Shih, Chun-Ming, Lin, Feng-Yen, Yeh, Jong-Shiuan, Lin, Yi-Wen, Loh, Shih-Hurng, Tsao, Nai-Wen, Nakagami, Hironori, Morishita, Ryuichi, Sawamura, Tatsuya, Li, Chi-Yuan, Lin, Cheng-Yen, Huang, Chun-Yao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2019; Elsevier BV
• Subjects: ACS = acute coronary syndrome; Adult; Aged; ALT= alanine transaminase; APOI = apocynin; CAD = coronary artery disease; CETP = cholesterol ester transfer protein; DCFH-DA = 2′,7′-dichlorofluorescin diacetate; Dyslipidemias; Endothelial Progenitor Cells; eNOS = endothelial nitric oxide synthase; Enzyme Activation; Female; HDL = high density lipoprotein; HPODE = hydroperoxyoctadeca-9Z,11E-dienoic acid; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Lipoxygenase; Male; Middle Aged; MNC = mononuclear cell; Nitric Oxide; NO = nitric oxide; p38 Mitogen-Activated Protein Kinases; PAH-AH = platelet-activating factor acetylhydrolase; PMA = phorbol 12-myristate 13-acetate; PON1 = paraoxonase-1; RHDL index = relative HDL index; rho-Associated Kinases; Signal Transduction; TBARS = thiobarbituric acid reactive substance; TC = total cholesterol; TG = triglycerides; HDL = high density lipoprotein; PON1 = paraoxonase-1; TBARS = thiobarbituric acid reactive substance; DCFH-DA = 2′,7′-dichlorofluorescin diacetate; HPODE = hydroperoxyoctadeca-9Z,11E-dienoic acid; TG = triglycerides; PMA = phorbol 12-myristate 13-acetate; eNOS = endothelial nitric oxide synthase; CETP = cholesterol ester transfer protein; RHDL index = relative HDL index; TC = total cholesterol; MNC = mononuclear cell; APOI = apocynin; NO = nitric oxide; ACS = acute coronary syndrome; ALT= alanine transaminase; PAH-AH = platelet-activating factor acetylhydrolase; CAD = coronary artery disease

Lipid metabolic disorders play critical roles in atherogenesis. Traditionally, it has been suggested that reduced high density lipoprotein (HDL) levels might be an important morbidity indicator for cardiovascular diseases. Therefore, it has been argued that therapeutically raising HDL levels may red...