Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease

• Published in: Journal of chemical neuroanatomy Vol. 42; no. 2; pp. 118 - 126
• Main Authors: Blalock, Eric M., Buechel, Heather M., Popovic, Jelena, Geddes, James W., Landfield, Philip W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2011
• Subjects: Aged, 80 and over; Aging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Axons - metabolism; Axons - pathology; Biomarkers - metabolism; Calcium Signaling - physiology; Cognitive impairment; Epigenesis, Genetic - genetics; Female; Glia; Hippocampus - metabolism; Hippocampus - pathology; Humans; Laser Capture Microdissection - methods; Male; Myelin; Neovascularization, Physiologic - physiology; Nerve Growth Factors - genetics; Neural Pathways - metabolism; Neural Pathways - pathology; Neurodegeneration; Neurofibrillary tangles; Neurons - metabolism; Neurons - pathology; Oligonucleotide Array Sequence Analysis - methods; Ryanodine Receptor Calcium Release Channel - genetics; Transcription Factors - genetics; Neurofibrillary tangles; AD; FFPE; Neurodegeneration; Myelin; MMSE; LCM; Aging; Glia; NFT; CA; Cognitive impairment

► Subjects ( N = 30) spanned control, incipient, moderate and severe Alzheimer's disease. ► Focused on microarray analyses of laser-dissected hippocampal gray matter. ► Array profiles largely agreed with a prior study of combined white and gray matter. ► Unique gray-matter AD changes included r...