Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis

• Published in: Journal of allergy and clinical immunology Vol. 133; no. 3; pp. 741 - 750
• Main Authors: Tomazic, Peter Valentin, MD, Birner-Gruenberger, Ruth, PhD, Leitner, Anita, Obrist, Britta, BSc, Spoerk, Stefan, Lang-Loidolt, Doris, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2014; Elsevier; Elsevier Limited
• Subjects: Adult; allergic rhinitis; Allergies; Allergy and Immunology; alpha-Macroglobulins - analysis; Apolipoprotein A-I - analysis; Apolipoprotein A-II - analysis; Biological and medical sciences; Biotechnology; Children & youth; Complement C3 - analysis; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunopathology; Laboratories; Male; mass spectrometry; Medical sciences; Metabolism; Metabolites; Middle Aged; Nasal Mucosa - chemistry; Nasal Mucosa - immunology; Nasal mucus; Non tumoral diseases; Nose; Otorhinolaryngology. Stomatology; Permeability; Proteins; proteome; proteomics; Proteomics - methods; Rhinitis, Allergic; Rhinitis, Allergic, Perennial - immunology; Rhinitis, Allergic, Perennial - metabolism; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Software; Statistical analysis; Tandem Mass Spectrometry; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Complement C5; GRN; SERPINA1; IgJ chain; Complement C3; HP; Apolipoprotein B-100; Vitronectin; BPI fold–containing family A member 1; Spectral count; α1-Antitrypsin; Antileukoproteinase; WFDC2; C3; SC; LC-MS/MS; VTN; BPIFA1; C5; Haptoglobin; mass spectrometry; A2M; Apolipoprotein A-4; APOB; Apolipoprotein A-2; Apolipoprotein A-1; Nasal mucus; α2-Macroglobulin; Lactotransferrin; proteomics; Liquid chromatography–tandem mass spectrometry; APOA2; APOA1; APOA4; Nonsecretory ribonuclease; LYZ; RNASE2; IGJ; proteome; Lysozyme C; Granulin; BPIFB1; SLPI; WAP 4-disulfide core domain protein; allergic rhinitis; BPI fold–containing family B member 1; LTF; Human; Allergy; Immunopathology; Nose disease; Immune response; Rhinitis; Exploration; Proteome; Mucus; Permeability; Immunology; Nose; Proteomics; ENT disease; Mass spectrometry

Background Nasal mucus is the first-line defense barrier against (aero-) allergens. However, its proteome and function have not been clearly investigated. Objective The role of nasal mucus in the pathophysiology of allergic rhinitis was investigated by analyzing its proteome in patients with allergi...