Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer

• Published in: Redox biology Vol. 46; p. 102130
• Main Authors: Chen, Chen, Gong, Lijie, Liu, Xiaoqin, Zhu, Tianyu, Zhou, Wuxi, Kong, Lingyi, Luo, Jianguang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2021; Elsevier
• Subjects: Covalent inhibitor; Non-small cell lung cancer; Oxidative stress; Peroxiredoxin 6; Research Paper; Withangulatin A; Peroxiredoxin 6; Oxidative stress; Withangulatin A; Covalent inhibitor; Non-small cell lung cancer

Peroxiredoxin 6 (PRDX6), as a bifunctional enzyme with glutathione peroxidase activity (GPx) and Ca2+-independent phospholipase A2 (iPLA2) activity, has a higher expression in various cancer cells, which leads to the increase of antioxidant properties and promotes tumorigenesis. However, only a few...