Circulating Long Noncoding RNA HOTAIR is an Essential Mediator of Acute Myocardial Infarction

• Published in: Cellular physiology and biochemistry Vol. 44; no. 4; pp. 1497 - 1508
• Main Authors: Gao, Lu, Liu, Yuan, Guo, Sen, Yao, Rui, Wu, Leiming, Xiao, Lili, Wang, Zheng, Liu, Yuzhou, Zhang, Yanzhou
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.12.2017; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Acute myocardial infarction; Aged; Animals; Apoptosis; Biomarkers; Biomarkers - blood; Cancer; Cardiac arrhythmia; Cardiology; Cardiomyocytes; Cardiovascular disease; Cell growth; Cell Hypoxia; Coronary vessels; Female; Gene expression; Heart attacks; Heart failure; Hospitals; HOTAIR; Humans; Hypoxia; Kinases; Laboratory animals; Long noncoding RNAs; Male; Medical research; Mice; MicroRNAs; Middle Aged; MiR-1; Mortality; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Original Paper; Ostomy; Plasma; Proteins; Rats; RNA, Long Noncoding - blood; Troponin I - blood; HOTAIR; Biomarkers; MiR-1; Acute myocardial infarction; Long noncoding RNAs
• ISSN: 1015-8987; 1421-9778; 1421-9778
• DOI: 10.1159/000485588

Background/Aims: Acute myocardial infarction (AMI) is one of the leading causes of death in the world. However, specific diagnostic biomarkers have not been fully determined, and candidate regulatory targets for AMI have not been identified to date. Long noncoding RNAs (lncRNAs) are a class of RNA m...