Direction-dependent activation of the insular cortex during vertical and horizontal hand movements

Highlights • The involvement of insular cortex during hand movements is investigated. • Insular cortex is activated during vertical hand movements without vision. • Insular cortex is not activated during horizontal hand movements without vision. • Insular cortex is sensitive to the effects of gravit...

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Published inNeuroscience Vol. 325; pp. 10 - 19
Main Authors Rousseau, C, Fautrelle, L, Papaxanthis, C, Fadiga, L, Pozzo, T, White, O
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 14.06.2016
Elsevier - International Brain Research Organization
Subjects
Adult
Brain - physiology
Brain Mapping
Cerebral Cortex - physiology
fMRI
Gravitation
gravitational force
Hand - physiology
hand movements
Humans
insular cortex
internal model
Life Sciences
Magnetic Resonance Imaging
Male
Middle Aged
Motor Activity
Movement
Neurology
Neurons and Cognition
Young Adult
HL
CNS
GLM
MNI
Vertical movement with additional load
blood oxygenation level-dependent
gravitational force
Horizontal movement with additional load
General Linear Model
Montreal Neurological Institute
fMRI
Central Nervous System
hand movements
VL
BOLD
internal model
insular cortex
gravity-field
sensory prediction
motion
manual interceptions
internal-models
human vestibular cortex
positron-emission-tomography
arm movements
pointing movements
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Abstract Highlights • The involvement of insular cortex during hand movements is investigated. • Insular cortex is activated during vertical hand movements without vision. • Insular cortex is not activated during horizontal hand movements without vision. • Insular cortex is sensitive to the effects of gravity on the moving limbs.
AbstractList •The involvement of insular cortex during hand movements is investigated.•Insular cortex is activated during vertical hand movements without vision.•Insular cortex is not activated during horizontal hand movements without vision.•Insular cortex is sensitive to the effects of gravity on the moving limbs. The planning of any motor action requires a complex multisensory processing by the brain. Gravity – immutable on Earth – has been shown to be a key input to these mechanisms. Seminal fMRI studies performed during visual perception of falling objects and self-motion demonstrated that humans represent the action of gravity in parts of the cortical vestibular system; in particular, the insular cortex and the cerebellum. However, little is known as to whether a specific neural network is engaged when processing non-visual signals relevant to gravity. We asked participants to perform vertical and horizontal hand movements without visual control, while lying in a 3T-MRI scanner. We highlighted brain regions activated in the processing of vertical movements, for which the effects of gravity changed during execution. Precisely, the left insula was activated in vertical movements and not in horizontal movements. Moreover, the network identified by contrasting vertical and horizontal movements overlapped with neural correlates previously associated to the processing of simulated self-motion and visual perception of the vertical direction. Interestingly, we found that the insular cortex activity is direction-dependent which suggests that this brain region processes the effects of gravity on the moving limbs through non-visual signals.
Highlights • The involvement of insular cortex during hand movements is investigated. • Insular cortex is activated during vertical hand movements without vision. • Insular cortex is not activated during horizontal hand movements without vision. • Insular cortex is sensitive to the effects of gravity on the moving limbs.
The planning of any motor action requires a complex multisensory processing by the brain. Gravity - immutable on Earth - has been shown to be a key input to these mechanisms. Seminal fMRI studies performed during visual perception of falling objects and self-motion demonstrated that humans represent the action of gravity in parts of the cortical vestibular system; in particular, the insular cortex and the cerebellum. However, little is known as to whether a specific neural network is engaged when processing non-visual signals relevant to gravity. We asked participants to perform vertical and horizontal hand movements without visual control, while lying in a 3T-MRI scanner. We highlighted brain regions activated in the processing of vertical movements, for which the effects of gravity changed during execution. Precisely, the left insula was activated in vertical movements and not in horizontal movements. Moreover, the network identified by contrasting vertical and horizontal movements overlapped with neural correlates previously associated to the processing of simulated self-motion and visual perception of the vertical direction. Interestingly, we found that the insular cortex activity is direction-dependent which suggests that this brain region processes the effects of gravity on the moving limbs through non-visual signals.
Author Fadiga, L
Pozzo, T
Rousseau, C
Fautrelle, L
Papaxanthis, C
White, O
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Keywords HL
CNS
GLM
MNI
Vertical movement with additional load
blood oxygenation level-dependent
gravitational force
Horizontal movement with additional load
General Linear Model
Montreal Neurological Institute
fMRI
Central Nervous System
hand movements
VL
BOLD
internal model
insular cortex
gravity-field
sensory prediction
motion
manual interceptions
internal-models
human vestibular cortex
positron-emission-tomography
arm movements
pointing movements
Language English
License Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
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SSID ssj0000543
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Snippet Highlights • The involvement of insular cortex during hand movements is investigated. • Insular cortex is activated during vertical hand movements without...
•The involvement of insular cortex during hand movements is investigated.•Insular cortex is activated during vertical hand movements without vision.•Insular...
The planning of any motor action requires a complex multisensory processing by the brain. Gravity - immutable on Earth - has been shown to be a key input to...
SourceID hal
proquest
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 10
SubjectTerms Adult
Brain - physiology
Brain Mapping
Cerebral Cortex - physiology
fMRI
Gravitation
gravitational force
Hand - physiology
hand movements
Humans
insular cortex
internal model
Life Sciences
Magnetic Resonance Imaging
Male
Middle Aged
Motor Activity
Movement
Neurology
Neurons and Cognition
Young Adult
Title Direction-dependent activation of the insular cortex during vertical and horizontal hand movements
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https://dx.doi.org/10.1016/j.neuroscience.2016.03.039
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