Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology

• Published in: Acta neuropathologica Vol. 131; no. 3; pp. 393 - 409
• Main Authors: Toledo, Jon B., Gopal, Pallavi, Raible, Kevin, Irwin, David J., Brettschneider, Johannes, Sedor, Samantha, Waits, Kayla, Boluda, Susana, Grossman, Murray, Van Deerlin, Vivianna M., Lee, Edward B., Arnold, Steven E., Duda, John E., Hurtig, Howard, Lee, Virginia M.-Y., Adler, Charles H., Beach, Thomas G., Trojanowski, John Q.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2016
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - analysis; Alzheimer Disease - complications; Alzheimer Disease - pathology; Cluster Analysis; Female; Humans; Lewy Bodies - pathology; Lewy Body Disease - complications; Lewy Body Disease - pathology; Male; Medicine; Medicine & Public Health; Neurosciences; Original Paper; Parkinson Disease - complications; Parkinson Disease - pathology; Pathology; Parkinson disease; Diagnosis; Alzheimer disease; Neuropathology; Classification; Dementia with Lewy bodies

We investigated the distribution patterns of Lewy body-related pathology (LRP) and the effect of coincident Alzheimer disease (AD) pathology using a data-driven clustering approach that identified groups with different LRP pathology distributions without any diagnostic or researcher’s input in two c...