Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis

• Published in: Science translational medicine Vol. 13; no. 600
• Main Authors: Kinoshita, Manao, Ogawa, Youichi, Hama, Natsumi, Ujiie, Inkin, Hasegawa, Akito, Nakajima, Saeko, Nomura, Takashi, Adachi, Jun, Sato, Takuya, Koizumi, Schuichi, Shimada, Shinji, Fujita, Yasuyuki, Takahashi, Hayato, Mizukawa, Yoshiko, Tomonaga, Takeshi, Nagao, Keisuke, Abe, Riichiro, Kawamura, Tatsuyoshi
• Format: Journal Article
• Language: English
• Published: United States 30.06.2021
• Subjects: CD8-Positive T-Lymphocytes; Humans; Keratinocytes; Neutrophils; Stevens-Johnson Syndrome; T-Lymphocytes, Cytotoxic

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous adverse drug reactions characterized by massive epidermal detachment. Cytotoxic T cells and associated effector molecules are known to drive SJS/TEN pathophysiology, but the contribution of innate...