TET2 Mutations in Acute Myeloid Leukemia (AML): Results From a Comprehensive Genetic and Clinical Analysis of the AML Study Group

• Published in: Journal of clinical oncology Vol. 30; no. 12; pp. 1350 - 1357
• Main Authors: GAIDZIK, Verena I, PASCHKA, Peter, BENTZ, Martin, GÖTZE, Katharina, DÖHNER, Hartmut, SCHLENK, Richard F, BULLINGER, Lars, DÖHNER, Konstanze, SPÄTH, Daniela, HABDANK, Marianne, KÖHNE, Claus-Henning, GERMING, Ulrich, VON LILIENFELD-TOAL, Marie, HELD, Gerhard, HORST, Heinz-August, HAASE, Detlef
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 20.04.2012
• Subjects: Acute myeloid leukemia; Adolescent; Adult; Age Factors; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Biological and medical sciences; Combined Modality Therapy; Cytogenetic Analysis; Data processing; DNA Mutational Analysis; DNA-Binding Proteins - genetics; Exons; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic analysis; Hematologic and hematopoietic diseases; Hematopoietic Stem Cell Transplantation - methods; Humans; Isocitrate dehydrogenase; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Mutation; Odds Ratio; Oncogenes; Prognosis; Proportional Hazards Models; Prospective Studies; Proto-Oncogene Proteins - genetics; Risk Assessment; Risk factors; Severity of Illness Index; Survival; Survival Rate; Transplantation, Homologous; Treatment Outcome; Tumors; Young Adult; TET2 gene; Acute myelogenous leukemia; Cancerology; Genetics; Malignant hemopathy; Mutation; Cancer; Tumor suppressor gene

The tet oncogene family member 2 (TET2) gene was recently identified to be mutated in myeloid disorders including acute myeloid leukemia (AML). To date, there is increasing evidence for a functional role of TET2 mutations (TET2(mut)) in AML. Thus, we explored the frequency, gene-expression pattern,...