Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections

• Published in: Journal of innate immunity Vol. 15; no. 1; pp. 50 - 66
• Main Authors: Narayanan, Divya, Moily, Nagaraj, McQuilten, Hayley A., Kedzierska, Katherine, Mackenzie, Jason M., Kedzierski, Lukasz, Fazakerley, John K.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger Publishers 01.01.2023
• Subjects: alphavirus; Animals; Antiviral Agents; Brain; Humans; Immunity, Innate; innate immunity; interferon; Interferon Type I; Mice; neuron; Neurons; Research Article; RNA Virus Infections; Virus Diseases; Alphavirus; Innate immunity; Interferon; Neuron

Abstract Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate antiviral responses mediated by type I interferons (IFNs) are crucially important in controlling CNS virus infections. The maturity of neuronal populations is an...