XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression

• Published in: JHEP reports Vol. 4; no. 11; p. 100555
• Main Authors: Wang, Qi, Bu, Qingfa, Liu, Mu, Zhang, Rui, Gu, Jian, Li, Lei, Zhou, Jinren, Liang, Yuan, Su, Wantong, Liu, Zheng, Wang, Mingming, Lian, Zhexiong, Lu, Ling, Zhou, Haoming
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2022; Elsevier
• Subjects: BNIP3; Liver fibrosis; Macrophage; Mitophagy; mtDNA; STING; XBP1; NAFLD; sXBP1; mtDNA; LC3B; Liver fibrosis; BDL; Mitophagy; ChIP; Acta2/α-SMA; LPS; TBK1; cGAS; BMDMs; HSC; KEGG; NLRP3; uXBP1; TLR; WT; EtBr; XBP1; Col1a1; BNIP3; Timp1; CM; NASH; DMXAA; ER; p62; PBMCs; MCD; IRF3; TNF-α; CCl4; IRE1α; MnSOD; ROS; STING; TGF-β1; shRNAs; Macrophage

XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is unknown. X-box binding protein 1 (XBP1) has been shown to promote macrophage nucleotide-binding oligomerization domain, leucine-rich repeat a...