Volatilomic insight of head and neck cancer via the effects observed on saliva metabolites

• Published in: Scientific reports Vol. 8; no. 1; pp. 17725 - 10
• Main Authors: Taware, Ravindra, Taunk, Khushman, Pereira, Jorge A. M., Shirolkar, Amey, Soneji, Dharmesh, Câmara, José S., Nagarajaram, H. A., Rapole, Srikanth
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.12.2018; Nature Publishing Group
• Subjects: 631/61/320; 631/67/1665/3016; 639/638/11/296; 692/53/2421; 82/58; Adaptation; Adult; Aged; Aged, 80 and over; Cancer; Case-Control Studies; Dichlorobenzene; Female; Gas chromatography; Gas Chromatography-Mass Spectrometry - methods; Head & neck cancer; Head and Neck Neoplasms - metabolism; Headspace; Humanities and Social Sciences; Humans; Male; Mass spectrometry; Mass spectroscopy; Metabolic Networks and Pathways - physiology; Metabolic pathways; Metabolism; Metabolites; Middle Aged; multidisciplinary; ROC Curve; Saliva; Saliva - metabolism; Science; Science (multidisciplinary); Solid phase methods; Solid Phase Microextraction - methods; Volatile Organic Compounds - metabolism; Volatile Organic Metabolites (VOMs); Metabolic Pathway Analysis; Saliva Samples; Class Segregation; Headspace Solid-phase Microextraction (HS-SPME)

Head and neck cancer (HNC) is a heterogeneous malignant disease with distinct global distribution. Metabolic adaptations of HNC are significantly gaining clinical interests nowadays. Here, we investigated effects of HNC on differential expression of volatile metabolites in human saliva. We applied h...