Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain

• Published in: Scientific reports Vol. 7; no. 1; pp. 14614 - 19
• Main Authors: Anderson, Christopher S., Ortega, Sandra, Chaves, Francisco A., Clark, Amelia M., Yang, Hongmei, Topham, David J., DeDiego, Marta L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.11.2017; Nature Publishing Group
• Subjects: 631/250/2152/2153/1291; 692/699/255/2514; Amino acid sequence; Amino acids; Antigenic drift; Antisera; Drift; HA protein; Hemagglutinins; Humanities and Social Sciences; Influenza; multidisciplinary; Mutation; Pandemics; Pathogenicity; Pathogens; Reproductive fitness; Science; Science (multidisciplinary); Vaccination; Virulence; Viruses

The induction of antibodies specific for the influenza HA protein stalk domain is being pursued as a universal strategy against influenza virus infections. However, little work has been done looking at natural or induced antigenic variability in this domain and the effects on viral fitness. We analy...