Expression of interferon regulatory factor 1, 3, and 7 in primary Sjögren syndrome

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 107; no. 5; pp. 661 - 668
• Main Authors: Zheng, Lingyan, Yu, Chuangqi, Zhang, Zhiyuan, Yang, Chi, Cai, Xieyi
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.2009; Elsevier
• Subjects: Adult; Aged; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Case-Control Studies; Epithelial Cells - metabolism; Female; Fluorescent Antibody Technique; Gene Expression; Humans; Interferon Regulatory Factor-1 - biosynthesis; Interferon Regulatory Factor-1 - genetics; Interferon Regulatory Factor-3 - biosynthesis; Interferon Regulatory Factor-3 - blood; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-7 - biosynthesis; Interferon Regulatory Factor-7 - blood; Interferon Regulatory Factor-7 - genetics; Interferon Regulatory Factors - biosynthesis; Interferon Regulatory Factors - blood; Interferon Regulatory Factors - genetics; Lymphocytes - metabolism; Male; Medical sciences; Middle Aged; Otorhinolaryngology. Stomatology; Parotid Gland - metabolism; Pharmacology. Drug treatments; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - blood; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sjogren's Syndrome - blood; Sjogren's Syndrome - genetics; Sjogren's Syndrome - immunology; Sjogren's Syndrome - metabolism; Surgery; Up-Regulation; Young Adult; Immunopathology; Eye disease; Stomatology; Systemic disease; Autoimmune disease; Antiviral; Interferon; Sjögren syndrome

The aim was to investigate the level of interferon regulatory factor (IRF) 1, 3, and 7 in peripheral blood cells from patients with primary Sjogren syndrome (pSS) and to determine whether and where IRF1 exists in the parotid glands of pSS. Peripheral blood cells and parotid gland biopsy specimens fr...