Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial

• Published in: The lancet oncology Vol. 17; no. 11; pp. 1509 - 1520
• Main Authors: Sun, Ying, Li, Wen-Fei, Chen, Nian-Yong, Zhang, Ning, Hu, Guo-Qing, Xie, Fang-Yun, Sun, Yan, Chen, Xiao-Zhong, Li, Jin-Gao, Zhu, Xiao-Dong, Hu, Chao-Su, Xu, Xiang-Ying, Chen, Yuan-Yuan, Hu, Wei-Han, Guo, Ling, Mo, Hao-Yuan, Chen, Lei, Mao, Yan-Ping, Sun, Rui, Ai, Ping, Liang, Shao-Bo, Long, Guo-Xian, Zheng, Bao-Min, Feng, Xing-Lai, Gong, Xiao-Chang, Li, Ling, Shen, Chun-Ying, Xu, Jian-Yu, Guo, Ying, Chen, Yu-Ming, Zhang, Fan, Lin, Li, Tang, Ling-Long, Liu, Meng-Zhong, Ma, Jun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2016; Elsevier Limited
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma; Chemoradiotherapy - adverse effects; Chemotherapy; Cisplatin - administration & dosage; Docetaxel; Female; Fluorouracil - administration & dosage; Head & neck cancer; Hematology; Hematology, Oncology and Palliative Medicine; Humans; Induction Chemotherapy - adverse effects; Male; Medical prognosis; Metastasis; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms - mortality; Nasopharyngeal Neoplasms - therapy; Neutropenia; Radiation therapy; Studies; Taxoids - administration & dosage

The value of adding cisplatin, fluorouracil, and docetaxel (TPF) induction chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma is unclear. We aimed to compare TPF induction chemotherapy plus concurrent chemoradiotherapy with concurrent chemoradiotherapy a...