SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis

• Published in: Biomedicines Vol. 10; no. 3; p. 532
• Main Authors: Bauset, Cristina, Lis-Lopez, Lluis, Coll, Sandra, Gisbert-Ferrándiz, Laura, Macias-Ceja, Dulce C., Seco-Cervera, Marta, Navarro, Francisco, Esplugues, Juan V., Calatayud, Sara, Ortiz-Masia, Dolores, Barrachina, Maria D., Cosín-Roger, Jesús
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.02.2022; MDPI
• Subjects: Body fat; Cardiomyocytes; Dendritic cells; Epithelial cells; Experiments; Homeostasis; Immune system; Inflammasomes; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Lipopolysaccharides; Metabolic pathways; Microbiota; Mucosa; Pathogens; Protein expression; Proteins; siRNA; SUCNR1; Ulcerative Colitis; United States > US; Spain; epithelial cells; Ulcerative Colitis; SUCNR1

Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of several inflammatory pathologies, such as Ulcerative Colitis (UC). Recently, the succinate receptor SUCNR1 was associated with the activation of i...