Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy

• Published in: Oncotarget Vol. 8; no. 68; pp. 112236 - 112244
• Main Authors: Amon, Ron, Ben-Arye, Shani Leviatan, Engler, Limor, Yu, Hai, Lim, Noha, Berre, Ludmilla Le, Harris, Kristina M., Ehlers, Mario R., Gitelman, Stephen E., Chen, Xi, Soulillou, Jean-Paul, Padler-Karavani, Vered
• Format: Journal Article
• Language: English
• Published: United States Impact journals 22.12.2017; Impact Journals LLC
• Subjects: Immunology; Life Sciences; Research Paper: Immunology; N-glycolylneuraminic acid; antibodies; Immunology; sialic acids; anti-thymocyte globulin; human

Humans have circulating antibodies against diverse glycans containing -glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the gene. This xenogenic non-human carbohydrate is abundant in red meat, xenografts and biotherapeutics. Low levels of diet-derived Neu5Gc is also present on norma...