Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy

• Published in: Free radical biology & medicine Vol. 87; pp. 263 - 273
• Main Authors: Umbarkar, Prachi, Singh, Sarojini, Arkat, Silpa, Bodhankar, S.L., Lohidasan, Sathiyanarayanan, Sitasawad, Sandhya L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2015
• Subjects: Animals; Antioxidants - metabolism; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Cardiac dysfunction; Clorgyline - administration & dosage; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetic Cardiomyopathies - genetics; Diabetic Cardiomyopathies - metabolism; Diabetic Cardiomyopathies - pathology; Diabetic cardiomyopathy; Fibrosis - genetics; Fibrosis - metabolism; Fibrosis - pathology; Free radicals; Humans; Lipid Peroxidation - genetics; Monoamine Oxidase - drug effects; Monoamine Oxidase - metabolism; Monoamine oxidase A; Monoamine Oxidase Inhibitors - administration & dosage; Myocardial Contraction - drug effects; Myocardium - metabolism; Myocardium - pathology; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Rats; Reactive Oxygen Species - metabolism; Ventricular Dysfunction, Left - metabolism; Ventricular Dysfunction, Left - pathology; MABP; Oxidative stress; LVSP; MDA; I/R; HW; LVEDP; TUNEL; BW; UCP3; Prx; STZ; Diabetic cardiomyopathy; DHPG; Monoamine oxidase A; Free radicals; ECG; GPx; Cardiac dysfunction; DCM; NE; ROS; COX IV; MAO; 5-HT; CLG; Apoptosis

Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium. We sought to determine whether MAO-A plays a major role in modulating DCM. Diabete...