Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy
Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium. We sought to determine whether MAO-A plays a major role in modulating DCM. Diabete...
Saved in:
Published in | Free radical biology & medicine Vol. 87; pp. 263 - 273 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.10.2015
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium. We sought to determine whether MAO-A plays a major role in modulating DCM. Diabetes was induced in Wistar rats by single intraperitoneal injection of streptozotocin (STZ). To investigate the role of MAO-A in the development of pathophysiological features of DCM, hyperglycemic and age-matched control rats were treated with or without the MAO-A-specific inhibitor clorgyline (CLG) at 1mg/kg/day for 8 weeks. Diabetes upregulated MAO-A activity; elevated markers of oxidative stress such as cardiac lipid peroxidation, superoxide dismutase activity, and UCP3 protein expression; enhanced apoptotic cell death; and increased fibrosis. All these parameters were significantly attenuated by CLG treatment. In addition, treatment with CLG substantially prevented diabetes-induced cardiac contractile dysfunction as evidenced by decreased QRS, QT, and corrected QT intervals, measured by ECG, and LV systolic and LV end-diastolic pressure measured by microtip pressure transducer. These beneficial effects of CLG were seen despite the persistent hyperglycemic and hyperlipidemic environments in STZ-induced experimental diabetes. In summary, this study provides strong evidence that MAO-A is an important source of oxidative stress in the heart and that MAO-A-derived reactive oxygen species contribute to DCM.
[Display omitted] |
---|---|
AbstractList | Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium. We sought to determine whether MAO-A plays a major role in modulating DCM. Diabetes was induced in Wistar rats by single intraperitoneal injection of streptozotocin (STZ). To investigate the role of MAO-A in the development of pathophysiological features of DCM, hyperglycemic and age-matched control rats were treated with or without the MAO-A-specific inhibitor clorgyline (CLG) at 1 mg/kg/day for 8 weeks. Diabetes upregulated MAO-A activity; elevated markers of oxidative stress such as cardiac lipid peroxidation, superoxide dismutase activity, and UCP3 protein expression; enhanced apoptotic cell death; and increased fibrosis. All these parameters were significantly attenuated by CLG treatment. In addition, treatment with CLG substantially prevented diabetes-induced cardiac contractile dysfunction as evidenced by decreased QRS, QT, and corrected QT intervals, measured by ECG, and LV systolic and LV end-diastolic pressure measured by microtip pressure transducer. These beneficial effects of CLG were seen despite the persistent hyperglycemic and hyperlipidemic environments in STZ-induced experimental diabetes. In summary, this study provides strong evidence that MAO-A is an important source of oxidative stress in the heart and that MAO-A-derived reactive oxygen species contribute to DCM. Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is an important source of oxidative stress in the myocardium. We sought to determine whether MAO-A plays a major role in modulating DCM. Diabetes was induced in Wistar rats by single intraperitoneal injection of streptozotocin (STZ). To investigate the role of MAO-A in the development of pathophysiological features of DCM, hyperglycemic and age-matched control rats were treated with or without the MAO-A-specific inhibitor clorgyline (CLG) at 1mg/kg/day for 8 weeks. Diabetes upregulated MAO-A activity; elevated markers of oxidative stress such as cardiac lipid peroxidation, superoxide dismutase activity, and UCP3 protein expression; enhanced apoptotic cell death; and increased fibrosis. All these parameters were significantly attenuated by CLG treatment. In addition, treatment with CLG substantially prevented diabetes-induced cardiac contractile dysfunction as evidenced by decreased QRS, QT, and corrected QT intervals, measured by ECG, and LV systolic and LV end-diastolic pressure measured by microtip pressure transducer. These beneficial effects of CLG were seen despite the persistent hyperglycemic and hyperlipidemic environments in STZ-induced experimental diabetes. In summary, this study provides strong evidence that MAO-A is an important source of oxidative stress in the heart and that MAO-A-derived reactive oxygen species contribute to DCM. [Display omitted] |
Author | Umbarkar, Prachi Singh, Sarojini Bodhankar, S.L. Lohidasan, Sathiyanarayanan Sitasawad, Sandhya L. Arkat, Silpa |
Author_xml | – sequence: 1 givenname: Prachi surname: Umbarkar fullname: Umbarkar, Prachi organization: National Centre for Cell Science, NCCS Complex, S.P. Pune University, Ganeshkhind, Pune 411007, Maharashtra, India – sequence: 2 givenname: Sarojini surname: Singh fullname: Singh, Sarojini organization: National Centre for Cell Science, NCCS Complex, S.P. Pune University, Ganeshkhind, Pune 411007, Maharashtra, India – sequence: 3 givenname: Silpa surname: Arkat fullname: Arkat, Silpa organization: National Centre for Cell Science, NCCS Complex, S.P. Pune University, Ganeshkhind, Pune 411007, Maharashtra, India – sequence: 4 givenname: S.L. surname: Bodhankar fullname: Bodhankar, S.L. organization: Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, India – sequence: 5 givenname: Sathiyanarayanan surname: Lohidasan fullname: Lohidasan, Sathiyanarayanan organization: Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, India – sequence: 6 givenname: Sandhya L. surname: Sitasawad fullname: Sitasawad, Sandhya L. email: ssitaswad@nccs.res.in organization: National Centre for Cell Science, NCCS Complex, S.P. Pune University, Ganeshkhind, Pune 411007, Maharashtra, India |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26122707$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkctu1DAUhi1U1E5LXwFZYsOiCbbjSyJWVdUWpCI2sLYc-0R4NLGD7VTMc_DCTZp2wY6VdeTvPxd95-gkxAAIfaCkpoTKT_t6SADJuN7HEVzNCBU1kTVh4g3a0VY1FRedPEE70na0Ei3vztB5zntCCBdNe4rOmKSMKaJ26O-3GKIZfQAc_3hnMlTX2GdsAvbjFFMxoeAc52QXYNiY4h8B55Igr5zDU4pjLJCxNcl5Y7E75mEOtvgYrrCZ4lRi9vnqGR58n9YK-4AXuIfi7RaM4zFOpvw6vkNvB3PIcPnyXqCfd7c_br5UD9_vv95cP1RWEFYqJjrbWt6QTvRDz6VgtpXSyUGqhqjeDoRzLpXi3DnFm15RpZywtLEdc0yK5gJ93PouB_yeIRc9-mzhcDAB4pw1VYwzSTpFFvTzhtpl-Zxg0FPyo0lHTYlerei9_seKXq1oIvViZUm_fxk09-vfa_ZVwwLcbgAs5z56SDpbD8GC8wls0S76_xr0BBUcqjg |
CitedBy_id | crossref_primary_10_1016_j_bbrep_2016_01_003 crossref_primary_10_1155_2019_7869318 crossref_primary_10_5582_bst_2018_01027 crossref_primary_10_1165_rcmb_2020_0105OC crossref_primary_10_1007_s11010_024_04951_z crossref_primary_10_1089_ars_2020_8122 crossref_primary_10_1016_j_foodchem_2021_129108 crossref_primary_10_1142_S0192415X18500775 crossref_primary_10_1155_2017_8391253 crossref_primary_10_1016_j_biopha_2017_05_148 crossref_primary_10_1021_acs_chemrestox_1c00153 crossref_primary_10_3390_biomedicines11030912 crossref_primary_10_1016_j_bbadis_2018_06_018 crossref_primary_10_1007_s10803_023_05925_8 crossref_primary_10_1007_s12013_023_01203_7 crossref_primary_10_3390_ijms24076459 crossref_primary_10_1007_s11010_017_2993_1 crossref_primary_10_1016_j_freeradbiomed_2022_12_103 crossref_primary_10_1007_s00395_023_01012_2 crossref_primary_10_1016_j_coph_2017_04_004 crossref_primary_10_1016_j_bmcl_2019_126677 crossref_primary_10_1016_j_coph_2017_04_003 crossref_primary_10_1155_2016_4375418 crossref_primary_10_1155_2017_9167450 crossref_primary_10_3390_membranes12111088 crossref_primary_10_1038_s41598_018_28029_1 crossref_primary_10_1016_j_arr_2021_101256 crossref_primary_10_1016_j_bmcl_2016_03_060 crossref_primary_10_1530_JOE_16_0004 crossref_primary_10_1016_j_freeradbiomed_2016_06_019 crossref_primary_10_3389_fcvm_2020_00012 crossref_primary_10_29328_journal_apps_1001057 crossref_primary_10_4236_ojd_2017_62004 crossref_primary_10_3390_ijms20061364 crossref_primary_10_1021_acs_chemrestox_1c00262 crossref_primary_10_1016_j_ecoenv_2019_109824 crossref_primary_10_1016_j_pestbp_2019_06_006 crossref_primary_10_3389_fnut_2023_1214420 crossref_primary_10_1111_jcmm_13477 crossref_primary_10_1007_s11010_022_04490_5 crossref_primary_10_1016_j_gene_2019_02_053 crossref_primary_10_1155_2022_9196232 crossref_primary_10_1002_ddr_21425 crossref_primary_10_1093_cvr_cvae012 crossref_primary_10_3390_biom13050800 crossref_primary_10_1016_j_semcancer_2017_04_005 crossref_primary_10_3390_cells13100856 crossref_primary_10_1155_2017_3017947 crossref_primary_10_1371_journal_pone_0296792 crossref_primary_10_1016_j_ejmech_2016_11_016 crossref_primary_10_3390_biomedicines10030602 crossref_primary_10_1007_s00702_018_1908_y crossref_primary_10_1155_2016_3869610 crossref_primary_10_1007_s11010_016_2767_1 crossref_primary_10_1155_2020_8260703 crossref_primary_10_1038_s41418_018_0071_1 crossref_primary_10_1002_ddr_21576 crossref_primary_10_1016_j_biopha_2023_115840 crossref_primary_10_1139_cjpp_2015_0587 crossref_primary_10_1016_j_dscb_2022_100050 crossref_primary_10_1016_j_phymed_2023_154673 crossref_primary_10_1016_j_freeradbiomed_2021_03_046 crossref_primary_10_1016_j_jacc_2017_05_043 crossref_primary_10_1016_j_jpba_2016_10_012 crossref_primary_10_1016_j_fct_2021_112214 crossref_primary_10_3390_cells11172697 |
Cites_doi | 10.1016/j.bbadis.2014.06.030 10.1007/BF00422364 10.1126/science.275.5303.1129 10.1113/expphysiol.2004.029439 10.1007/BF01942510 10.1358/mf.2002.24.8.705070 10.1080/003655100750046486 10.1007/s10286-007-0450-z 10.1126/science.281.5381.1309 10.1006/abio.1996.9997 10.1016/j.jpba.2006.07.030 10.1152/ajplegacy.1974.227.3.613 10.1016/j.jacc.2006.07.022 10.1385/CT:1:3:181 10.2337/diacare.17.7.633 10.2337/diabetes.51.6.1938 10.1016/j.jacc.2003.11.043 10.1152/physrev.1999.79.1.215 10.1038/mp.2011.50 10.1152/ajpheart.01328.2005 10.1093/eurheartj/5.suppl_F.347 10.1006/abio.1997.2392 10.1159/000064682 10.1016/0891-5849(94)90092-2 10.1371/journal.pone.0092697 10.1016/j.jacc.2008.05.019 10.1083/jcb.124.1.1 10.1126/science.275.5303.1132 10.1161/01.CIR.101.8.899 10.1161/CIRCULATIONAHA.109.897496 10.1161/01.RES.0000253900.66640.34 10.1016/j.bbamcr.2010.09.010 10.1089/ars.2011.4373 10.1152/ajpheart.00345.2004 10.1016/j.bbabio.2009.04.001 10.1186/1741-7015-10-40 10.1161/CIRCRESAHA.109.198366 10.1161/CIRCULATIONAHA.104.528133 10.1161/01.STR.0000085084.15144.66 10.1371/journal.pone.0067009 10.2337/diab.40.4.405 10.1161/01.RES.0000207406.94146.c2 |
ContentType | Journal Article |
Copyright | 2015 The Authors Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
Copyright_xml | – notice: 2015 The Authors – notice: Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.freeradbiomed.2015.06.025 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Biology |
EISSN | 1873-4596 |
EndPage | 273 |
ExternalDocumentID | 10_1016_j_freeradbiomed_2015_06_025 26122707 S0891584915002932 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- --K --M -~X .GJ .HR .~1 0R~ 1B1 1RT 1~. 1~5 29H 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABFNM ABFRF ABGSF ABJNI ABLJU ABLVK ABMAC ABMZM ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HLW HMK HMO HVGLF HX~ HZ~ IHE J1W KOM LCYCR LX3 LZ2 M29 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SBG SCC SDF SDG SDP SES SEW SPCBC SSH SSU SSZ T5K TEORI WUQ XPP ZGI ~G- AAXKI AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c502t-259c8c43095bfb4652c866d6f67307bcf044467744dd743b7177d5c13c92d2653 |
IEDL.DBID | AIKHN |
ISSN | 0891-5849 |
IngestDate | Fri Aug 16 22:04:34 EDT 2024 Thu Sep 26 15:56:45 EDT 2024 Sat Sep 28 08:06:44 EDT 2024 Fri Feb 23 02:21:36 EST 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | MABP Oxidative stress LVSP MDA I/R HW LVEDP TUNEL BW UCP3 Prx STZ Diabetic cardiomyopathy DHPG Monoamine oxidase A Free radicals ECG GPx Cardiac dysfunction DCM NE ROS COX IV MAO 5-HT CLG Apoptosis |
Language | English |
License | http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c502t-259c8c43095bfb4652c866d6f67307bcf044467744dd743b7177d5c13c92d2653 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S0891584915002932 |
PMID | 26122707 |
PQID | 1724260970 |
PQPubID | 23479 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_1724260970 crossref_primary_10_1016_j_freeradbiomed_2015_06_025 pubmed_primary_26122707 elsevier_sciencedirect_doi_10_1016_j_freeradbiomed_2015_06_025 |
PublicationCentury | 2000 |
PublicationDate | 2015-10-01 |
PublicationDateYYYYMMDD | 2015-10-01 |
PublicationDate_xml | – month: 10 year: 2015 text: 2015-10-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Free radical biology & medicine |
PublicationTitleAlternate | Free Radic Biol Med |
PublicationYear | 2015 |
Publisher | Elsevier Inc |
Publisher_xml | – name: Elsevier Inc |
References | Chen, Saari, Kang (bib4) 1994; 17 Villeneuve, Guilbeau-Frugier, Sicard, Lairez, Ordener, Duparc (bib11) 2013; 18 Kaludercic, Takimoto, Nagayama, Feng, Lai, Bedja (bib10) 2010; 106 Pchejetski, Kunduzova, Dayon, Calise, Seguelas, Leducq (bib14) 2007; 100 Varga, Giricz, Liaudet, Hasko, Ferdinandy, Pacher (bib30) 2015; 1852 Cai, Wang, Zhou, Chen, Song, Li (bib7) 2006; 48 Zhang, Babcock, Hu, Maris, Wang, Ren (bib22) 2012; 10 Cai, Li, Wang, Guo, Jiang, Kang (bib24) 2002; 51 Kumar, Prasad, Sitasawad (bib5) 2013; 8 Grousset, Menasche, Apstein, Mouas, Marotte, Piwnica (bib35) 1984; 5 Zhou, Panchuk-Voloshina (bib20) 1997; 253 Raev (bib31) 1994; 17 Stern, Sclarowsky (bib38) 2009; 120 Guo, Xia, Jiang, McNeill (bib6) 2007; 292 Yang, Liu, Bhalla, Kim, Ibrado, Cai (bib27) 1997; 275 Zhou, Li, Hein, Xiang, Marshall, Prabhu (bib23) 2008; 52 Heffernan, Jae, Fernhall (bib16) 2007; 17 Cai, Kang (bib29) 2001; 1 Ogata, Miyauchi, Sakai, Takanashi, Irukayama-Tomobe, Yamaguchi (bib36) 2004; 43 Baynes (bib3) 1991; 40 Reed (bib25) 1994; 124 Maggi, Meli (bib15) 1986; 42 Kluck, Bossy-Wetzel, Green, Newmeyer (bib26) 1997; 275 Jacobsen, Siesser, Sachs, Peterson, Cools, Setola (bib21) 2012; 17 Schannwell, Schneppenheim, Perings, Plehn, Strauer (bib32) 2002; 98 Kaludercic, Carpi, Menabo, Di, Paolocci (bib9) 2011; 1813 Badole, Jangam, Chaudhari, Ghule, Zanwar (bib42) 2014; 9 Swynghedauw (bib2) 1999; 79 Green, Reed (bib28) 1998; 281 Mizushige, Yao, Noma, Kiyomoto, Yu, Hosomi, Ohmori, Matsuo (bib37) 2000; 101 Poornima, Parikh, Shannon (bib1) 2006; 98 Rosen, Ballhausen, Bloch, Addicks (bib8) 1995; 38 Howarth, Jacobson, Naseer, Adeghate (bib39) 2005; 90 Christensen, Gall, Major-Pedersen, Sato, Rossing, Breum (bib40) 2000; 60 Cardoso, Salles, Deccache (bib41) 2003; 34 Carpi, Menabo, Kaludercic, Pelicci, Di, Giorgio (bib12) 2009; 1787 Gupta, Sharma, Chaudhary (bib17) 2002; 24 Bianchi, Kunduzova, Masini, Cambon, Bani, Raimondi (bib13) 2005; 112 Grotto, Santa Maria, Boeira, Valentini, Charao, Moro (bib18) 2007; 43 Lakshmana, Raju (bib19) 1997; 246 Weisfeldt, Scully, Frederiksen, Rubenstein, Pohost, Beierholm (bib33) 1974; 227 Slama, Ahn, Peltier, Maizel, Chemla, Varagic (bib34) 2005; 289 Zhou (10.1016/j.freeradbiomed.2015.06.025_bib23) 2008; 52 Kaludercic (10.1016/j.freeradbiomed.2015.06.025_bib10) 2010; 106 Ogata (10.1016/j.freeradbiomed.2015.06.025_bib36) 2004; 43 Carpi (10.1016/j.freeradbiomed.2015.06.025_bib12) 2009; 1787 Heffernan (10.1016/j.freeradbiomed.2015.06.025_bib16) 2007; 17 Baynes (10.1016/j.freeradbiomed.2015.06.025_bib3) 1991; 40 Green (10.1016/j.freeradbiomed.2015.06.025_bib28) 1998; 281 Maggi (10.1016/j.freeradbiomed.2015.06.025_bib15) 1986; 42 Weisfeldt (10.1016/j.freeradbiomed.2015.06.025_bib33) 1974; 227 Stern (10.1016/j.freeradbiomed.2015.06.025_bib38) 2009; 120 Cai (10.1016/j.freeradbiomed.2015.06.025_bib7) 2006; 48 Kaludercic (10.1016/j.freeradbiomed.2015.06.025_bib9) 2011; 1813 Mizushige (10.1016/j.freeradbiomed.2015.06.025_bib37) 2000; 101 Reed (10.1016/j.freeradbiomed.2015.06.025_bib25) 1994; 124 Varga (10.1016/j.freeradbiomed.2015.06.025_bib30) 2015; 1852 Christensen (10.1016/j.freeradbiomed.2015.06.025_bib40) 2000; 60 Lakshmana (10.1016/j.freeradbiomed.2015.06.025_bib19) 1997; 246 Cardoso (10.1016/j.freeradbiomed.2015.06.025_bib41) 2003; 34 Guo (10.1016/j.freeradbiomed.2015.06.025_bib6) 2007; 292 Grousset (10.1016/j.freeradbiomed.2015.06.025_bib35) 1984; 5 Badole (10.1016/j.freeradbiomed.2015.06.025_bib42) 2014; 9 Raev (10.1016/j.freeradbiomed.2015.06.025_bib31) 1994; 17 Cai (10.1016/j.freeradbiomed.2015.06.025_bib24) 2002; 51 Yang (10.1016/j.freeradbiomed.2015.06.025_bib27) 1997; 275 Kluck (10.1016/j.freeradbiomed.2015.06.025_bib26) 1997; 275 Bianchi (10.1016/j.freeradbiomed.2015.06.025_bib13) 2005; 112 Slama (10.1016/j.freeradbiomed.2015.06.025_bib34) 2005; 289 Zhou (10.1016/j.freeradbiomed.2015.06.025_bib20) 1997; 253 Zhang (10.1016/j.freeradbiomed.2015.06.025_bib22) 2012; 10 Gupta (10.1016/j.freeradbiomed.2015.06.025_bib17) 2002; 24 Schannwell (10.1016/j.freeradbiomed.2015.06.025_bib32) 2002; 98 Poornima (10.1016/j.freeradbiomed.2015.06.025_bib1) 2006; 98 Kumar (10.1016/j.freeradbiomed.2015.06.025_bib5) 2013; 8 Jacobsen (10.1016/j.freeradbiomed.2015.06.025_bib21) 2012; 17 Chen (10.1016/j.freeradbiomed.2015.06.025_bib4) 1994; 17 Howarth (10.1016/j.freeradbiomed.2015.06.025_bib39) 2005; 90 Swynghedauw (10.1016/j.freeradbiomed.2015.06.025_bib2) 1999; 79 Pchejetski (10.1016/j.freeradbiomed.2015.06.025_bib14) 2007; 100 Villeneuve (10.1016/j.freeradbiomed.2015.06.025_bib11) 2013; 18 Grotto (10.1016/j.freeradbiomed.2015.06.025_bib18) 2007; 43 Cai (10.1016/j.freeradbiomed.2015.06.025_bib29) 2001; 1 Rosen (10.1016/j.freeradbiomed.2015.06.025_bib8) 1995; 38 |
References_xml | – volume: 1 start-page: 181 year: 2001 end-page: 193 ident: bib29 article-title: Oxidative stress and diabetic cardiomyopathy: a brief review publication-title: Cardiovasc. Toxicol. contributor: fullname: Kang – volume: 8 start-page: e67009 year: 2013 ident: bib5 article-title: Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats publication-title: PLoS One contributor: fullname: Sitasawad – volume: 275 start-page: 1132 year: 1997 end-page: 1136 ident: bib26 article-title: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis publication-title: Science contributor: fullname: Newmeyer – volume: 1852 start-page: 232 year: 2015 end-page: 242 ident: bib30 article-title: Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy publication-title: Biochim. Biophys. Acta contributor: fullname: Pacher – volume: 106 start-page: 193 year: 2010 end-page: 202 ident: bib10 article-title: Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload publication-title: Circ. Res. contributor: fullname: Bedja – volume: 34 start-page: 2187 year: 2003 end-page: 2194 ident: bib41 article-title: QTc interval prolongation is a predictor of future strokes in patients with type 2 diabetes mellitus publication-title: Stroke contributor: fullname: Deccache – volume: 98 start-page: 596 year: 2006 end-page: 605 ident: bib1 article-title: Diabetic cardiomyopathy: the search for a unifying hypothesis publication-title: Circ. Res. contributor: fullname: Shannon – volume: 281 start-page: 1309 year: 1998 end-page: 1312 ident: bib28 article-title: Mitochondria and apoptosis publication-title: Science contributor: fullname: Reed – volume: 40 start-page: 405 year: 1991 end-page: 412 ident: bib3 article-title: Role of oxidative stress in development of complications in diabetes publication-title: Diabetes contributor: fullname: Baynes – volume: 43 start-page: 619 year: 2007 end-page: 624 ident: bib18 article-title: Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection publication-title: J. Pharm. Biomed. Anal. contributor: fullname: Moro – volume: 17 start-page: 633 year: 1994 end-page: 639 ident: bib31 article-title: Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients publication-title: Diabetes Care contributor: fullname: Raev – volume: 18 start-page: 5 year: 2013 end-page: 18 ident: bib11 article-title: p53-PGC-1alpha pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice publication-title: Antioxid. Redox Signaling contributor: fullname: Duparc – volume: 100 start-page: 41 year: 2007 end-page: 49 ident: bib14 article-title: Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis publication-title: Circ. Res. contributor: fullname: Leducq – volume: 292 start-page: H1728 year: 2007 end-page: H1736 ident: bib6 article-title: Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine publication-title: Am. J. Physiol. Heart Circ. Physiol contributor: fullname: McNeill – volume: 24 start-page: 497 year: 2002 end-page: 500 ident: bib17 article-title: Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents publication-title: Methods Find. Exp. Clin. Pharmacol. contributor: fullname: Chaudhary – volume: 246 start-page: 166 year: 1997 end-page: 170 ident: bib19 article-title: An isocratic assay for norepinephrine, dopamine, and 5-hydroxytryptamine using their native fluorescence by high-performance liquid chromatography with fluorescence detection in discrete brain areas of rat publication-title: Anal. Biochem. contributor: fullname: Raju – volume: 17 start-page: 529 year: 1994 end-page: 536 ident: bib4 article-title: Weak antioxidant defenses make the heart a target for damage in copper-deficient rats publication-title: Free Radic. Biol. Med. contributor: fullname: Kang – volume: 1813 start-page: 1323 year: 2011 end-page: 1332 ident: bib9 article-title: Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury publication-title: Biochim. Biophys. Acta contributor: fullname: Paolocci – volume: 51 start-page: 1938 year: 2002 end-page: 1948 ident: bib24 article-title: Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway publication-title: Diabetes contributor: fullname: Kang – volume: 42 start-page: 292 year: 1986 end-page: 297 ident: bib15 article-title: Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2. Cardiovascular system publication-title: Experientia contributor: fullname: Meli – volume: 98 start-page: 33 year: 2002 end-page: 39 ident: bib32 article-title: Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy publication-title: Cardiology contributor: fullname: Strauer – volume: 124 start-page: 1 year: 1994 end-page: 6 ident: bib25 article-title: Bcl-2 and the regulation of programmed cell death publication-title: J. Cell Biol. contributor: fullname: Reed – volume: 227 start-page: 613 year: 1974 end-page: 621 ident: bib33 article-title: Hemodynamic determinants of maximum negative dP-dt and periods of diastole publication-title: Am. J. Physiol. contributor: fullname: Beierholm – volume: 17 start-page: 356 year: 2007 end-page: 363 ident: bib16 article-title: Heart rate recovery after exercise is associated with resting QTc interval in young men publication-title: Clin. Auton. Res. contributor: fullname: Fernhall – volume: 38 start-page: 1157 year: 1995 end-page: 1168 ident: bib8 article-title: Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant publication-title: Diabetologia contributor: fullname: Addicks – volume: 17 start-page: 694 year: 2012 end-page: 704 ident: bib21 article-title: Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice publication-title: Mol. Psychiatry contributor: fullname: Setola – volume: 101 start-page: 899 year: 2000 end-page: 907 ident: bib37 article-title: Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model publication-title: Circulation contributor: fullname: Matsuo – volume: 1787 start-page: 774 year: 2009 end-page: 780 ident: bib12 article-title: The cardioprotective effects elicited by p66 (Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury publication-title: Biochim. Biophys. Acta contributor: fullname: Giorgio – volume: 289 start-page: H1131 year: 2005 end-page: H1136 ident: bib34 article-title: Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats publication-title: Am. J. Physiol. Heart Circ. Physiol contributor: fullname: Varagic – volume: 5 start-page: 347 year: 1984 end-page: 353 ident: bib35 article-title: Protective effects of cardioplegia on diastolic function of hypertrophied rat hearts after hypothermic ischaemic arrest publication-title: Eur. Heart J. contributor: fullname: Piwnica – volume: 48 start-page: 1688 year: 2006 end-page: 1697 ident: bib7 article-title: Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy publication-title: J. Am. Coll. Cardiol. contributor: fullname: Li – volume: 79 start-page: 215 year: 1999 end-page: 262 ident: bib2 article-title: Molecular mechanisms of myocardial remodeling publication-title: Physiol. Rev. contributor: fullname: Swynghedauw – volume: 112 start-page: 3297 year: 2005 end-page: 3305 ident: bib13 article-title: Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and post ischemic myocardial injury publication-title: Circulation contributor: fullname: Raimondi – volume: 253 start-page: 169 year: 1997 end-page: 174 ident: bib20 article-title: A one-step fluorometric method for the continuous measurement of monoamine oxidase activity publication-title: Anal. Biochem. contributor: fullname: Panchuk-Voloshina – volume: 10 start-page: 40 year: 2012 ident: bib22 article-title: Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3beta and mitochondrial function publication-title: BMC Med. contributor: fullname: Ren – volume: 275 start-page: 1129 year: 1997 end-page: 1132 ident: bib27 article-title: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked publication-title: Science contributor: fullname: Cai – volume: 120 start-page: 1633 year: 2009 end-page: 1636 ident: bib38 article-title: The ECG in diabetes mellitus publication-title: Circulation contributor: fullname: Sclarowsky – volume: 90 start-page: 237 year: 2005 end-page: 245 ident: bib39 article-title: Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats publication-title: Exp. Physiol. contributor: fullname: Adeghate – volume: 52 start-page: 655 year: 2008 end-page: 666 ident: bib23 article-title: Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart publication-title: J. Am. Coll. Cardiol. contributor: fullname: Prabhu – volume: 9 start-page: e92697 year: 2014 ident: bib42 article-title: L-Glutamine supplementation prevents the development of experimental diabetic cardiomyopathy in streptozotocin-nicotinamide induced diabetic rats publication-title: PLoS One contributor: fullname: Zanwar – volume: 43 start-page: 1481 year: 2004 end-page: 1488 ident: bib36 article-title: Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway publication-title: J. Am. Coll. Cardiol. contributor: fullname: Yamaguchi – volume: 60 start-page: 323 year: 2000 end-page: 332 ident: bib40 article-title: QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes publication-title: Scand. J. Clin. Lab. Invest. contributor: fullname: Breum – volume: 1852 start-page: 232 year: 2015 ident: 10.1016/j.freeradbiomed.2015.06.025_bib30 article-title: Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2014.06.030 contributor: fullname: Varga – volume: 38 start-page: 1157 year: 1995 ident: 10.1016/j.freeradbiomed.2015.06.025_bib8 article-title: Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant publication-title: Diabetologia doi: 10.1007/BF00422364 contributor: fullname: Rosen – volume: 275 start-page: 1129 year: 1997 ident: 10.1016/j.freeradbiomed.2015.06.025_bib27 article-title: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked publication-title: Science doi: 10.1126/science.275.5303.1129 contributor: fullname: Yang – volume: 90 start-page: 237 year: 2005 ident: 10.1016/j.freeradbiomed.2015.06.025_bib39 article-title: Short-term effects of streptozotocin-induced diabetes on the electrocardiogram, physical activity and body temperature in rats publication-title: Exp. Physiol. doi: 10.1113/expphysiol.2004.029439 contributor: fullname: Howarth – volume: 42 start-page: 292 year: 1986 ident: 10.1016/j.freeradbiomed.2015.06.025_bib15 article-title: Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2. Cardiovascular system publication-title: Experientia doi: 10.1007/BF01942510 contributor: fullname: Maggi – volume: 24 start-page: 497 year: 2002 ident: 10.1016/j.freeradbiomed.2015.06.025_bib17 article-title: Pyrogallol-induced hepatotoxicity in rats: a model to evaluate antioxidant hepatoprotective agents publication-title: Methods Find. Exp. Clin. Pharmacol. doi: 10.1358/mf.2002.24.8.705070 contributor: fullname: Gupta – volume: 60 start-page: 323 year: 2000 ident: 10.1016/j.freeradbiomed.2015.06.025_bib40 article-title: QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes publication-title: Scand. J. Clin. Lab. Invest. doi: 10.1080/003655100750046486 contributor: fullname: Christensen – volume: 17 start-page: 356 year: 2007 ident: 10.1016/j.freeradbiomed.2015.06.025_bib16 article-title: Heart rate recovery after exercise is associated with resting QTc interval in young men publication-title: Clin. Auton. Res. doi: 10.1007/s10286-007-0450-z contributor: fullname: Heffernan – volume: 281 start-page: 1309 year: 1998 ident: 10.1016/j.freeradbiomed.2015.06.025_bib28 article-title: Mitochondria and apoptosis publication-title: Science doi: 10.1126/science.281.5381.1309 contributor: fullname: Green – volume: 246 start-page: 166 year: 1997 ident: 10.1016/j.freeradbiomed.2015.06.025_bib19 article-title: An isocratic assay for norepinephrine, dopamine, and 5-hydroxytryptamine using their native fluorescence by high-performance liquid chromatography with fluorescence detection in discrete brain areas of rat publication-title: Anal. Biochem. doi: 10.1006/abio.1996.9997 contributor: fullname: Lakshmana – volume: 43 start-page: 619 year: 2007 ident: 10.1016/j.freeradbiomed.2015.06.025_bib18 article-title: Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection publication-title: J. Pharm. Biomed. Anal. doi: 10.1016/j.jpba.2006.07.030 contributor: fullname: Grotto – volume: 227 start-page: 613 year: 1974 ident: 10.1016/j.freeradbiomed.2015.06.025_bib33 article-title: Hemodynamic determinants of maximum negative dP-dt and periods of diastole publication-title: Am. J. Physiol. doi: 10.1152/ajplegacy.1974.227.3.613 contributor: fullname: Weisfeldt – volume: 48 start-page: 1688 year: 2006 ident: 10.1016/j.freeradbiomed.2015.06.025_bib7 article-title: Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2006.07.022 contributor: fullname: Cai – volume: 1 start-page: 181 year: 2001 ident: 10.1016/j.freeradbiomed.2015.06.025_bib29 article-title: Oxidative stress and diabetic cardiomyopathy: a brief review publication-title: Cardiovasc. Toxicol. doi: 10.1385/CT:1:3:181 contributor: fullname: Cai – volume: 17 start-page: 633 year: 1994 ident: 10.1016/j.freeradbiomed.2015.06.025_bib31 article-title: Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients publication-title: Diabetes Care doi: 10.2337/diacare.17.7.633 contributor: fullname: Raev – volume: 51 start-page: 1938 year: 2002 ident: 10.1016/j.freeradbiomed.2015.06.025_bib24 article-title: Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway publication-title: Diabetes doi: 10.2337/diabetes.51.6.1938 contributor: fullname: Cai – volume: 43 start-page: 1481 year: 2004 ident: 10.1016/j.freeradbiomed.2015.06.025_bib36 publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2003.11.043 contributor: fullname: Ogata – volume: 79 start-page: 215 year: 1999 ident: 10.1016/j.freeradbiomed.2015.06.025_bib2 article-title: Molecular mechanisms of myocardial remodeling publication-title: Physiol. Rev. doi: 10.1152/physrev.1999.79.1.215 contributor: fullname: Swynghedauw – volume: 17 start-page: 694 year: 2012 ident: 10.1016/j.freeradbiomed.2015.06.025_bib21 article-title: Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.50 contributor: fullname: Jacobsen – volume: 292 start-page: H1728 year: 2007 ident: 10.1016/j.freeradbiomed.2015.06.025_bib6 article-title: Downregulation of NADPH oxidase, antioxidant enzymes, and inflammatory markers in the heart of streptozotocin-induced diabetic rats by N-acetyl-L-cysteine publication-title: Am. J. Physiol. Heart Circ. Physiol doi: 10.1152/ajpheart.01328.2005 contributor: fullname: Guo – volume: 5 start-page: 347 issue: Suppl. F year: 1984 ident: 10.1016/j.freeradbiomed.2015.06.025_bib35 article-title: Protective effects of cardioplegia on diastolic function of hypertrophied rat hearts after hypothermic ischaemic arrest publication-title: Eur. Heart J. doi: 10.1093/eurheartj/5.suppl_F.347 contributor: fullname: Grousset – volume: 253 start-page: 169 year: 1997 ident: 10.1016/j.freeradbiomed.2015.06.025_bib20 article-title: A one-step fluorometric method for the continuous measurement of monoamine oxidase activity publication-title: Anal. Biochem. doi: 10.1006/abio.1997.2392 contributor: fullname: Zhou – volume: 98 start-page: 33 year: 2002 ident: 10.1016/j.freeradbiomed.2015.06.025_bib32 article-title: Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy publication-title: Cardiology doi: 10.1159/000064682 contributor: fullname: Schannwell – volume: 17 start-page: 529 year: 1994 ident: 10.1016/j.freeradbiomed.2015.06.025_bib4 article-title: Weak antioxidant defenses make the heart a target for damage in copper-deficient rats publication-title: Free Radic. Biol. Med. doi: 10.1016/0891-5849(94)90092-2 contributor: fullname: Chen – volume: 9 start-page: e92697 year: 2014 ident: 10.1016/j.freeradbiomed.2015.06.025_bib42 article-title: L-Glutamine supplementation prevents the development of experimental diabetic cardiomyopathy in streptozotocin-nicotinamide induced diabetic rats publication-title: PLoS One doi: 10.1371/journal.pone.0092697 contributor: fullname: Badole – volume: 52 start-page: 655 year: 2008 ident: 10.1016/j.freeradbiomed.2015.06.025_bib23 article-title: Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2008.05.019 contributor: fullname: Zhou – volume: 124 start-page: 1 year: 1994 ident: 10.1016/j.freeradbiomed.2015.06.025_bib25 article-title: Bcl-2 and the regulation of programmed cell death publication-title: J. Cell Biol. doi: 10.1083/jcb.124.1.1 contributor: fullname: Reed – volume: 275 start-page: 1132 year: 1997 ident: 10.1016/j.freeradbiomed.2015.06.025_bib26 article-title: The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis publication-title: Science doi: 10.1126/science.275.5303.1132 contributor: fullname: Kluck – volume: 101 start-page: 899 year: 2000 ident: 10.1016/j.freeradbiomed.2015.06.025_bib37 article-title: Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulin-resistant prediabetic stage of a type II diabetic rat model publication-title: Circulation doi: 10.1161/01.CIR.101.8.899 contributor: fullname: Mizushige – volume: 120 start-page: 1633 year: 2009 ident: 10.1016/j.freeradbiomed.2015.06.025_bib38 article-title: The ECG in diabetes mellitus publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.109.897496 contributor: fullname: Stern – volume: 100 start-page: 41 year: 2007 ident: 10.1016/j.freeradbiomed.2015.06.025_bib14 article-title: Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis publication-title: Circ. Res. doi: 10.1161/01.RES.0000253900.66640.34 contributor: fullname: Pchejetski – volume: 1813 start-page: 1323 year: 2011 ident: 10.1016/j.freeradbiomed.2015.06.025_bib9 article-title: Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2010.09.010 contributor: fullname: Kaludercic – volume: 18 start-page: 5 year: 2013 ident: 10.1016/j.freeradbiomed.2015.06.025_bib11 article-title: p53-PGC-1alpha pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice publication-title: Antioxid. Redox Signaling doi: 10.1089/ars.2011.4373 contributor: fullname: Villeneuve – volume: 289 start-page: H1131 year: 2005 ident: 10.1016/j.freeradbiomed.2015.06.025_bib34 article-title: Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats publication-title: Am. J. Physiol. Heart Circ. Physiol doi: 10.1152/ajpheart.00345.2004 contributor: fullname: Slama – volume: 1787 start-page: 774 year: 2009 ident: 10.1016/j.freeradbiomed.2015.06.025_bib12 article-title: The cardioprotective effects elicited by p66 (Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbabio.2009.04.001 contributor: fullname: Carpi – volume: 10 start-page: 40 year: 2012 ident: 10.1016/j.freeradbiomed.2015.06.025_bib22 article-title: Mitochondrial aldehyde dehydrogenase (ALDH2) protects against streptozotocin-induced diabetic cardiomyopathy: role of GSK3beta and mitochondrial function publication-title: BMC Med. doi: 10.1186/1741-7015-10-40 contributor: fullname: Zhang – volume: 106 start-page: 193 year: 2010 ident: 10.1016/j.freeradbiomed.2015.06.025_bib10 article-title: Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.109.198366 contributor: fullname: Kaludercic – volume: 112 start-page: 3297 year: 2005 ident: 10.1016/j.freeradbiomed.2015.06.025_bib13 article-title: Oxidative stress by monoamine oxidase mediates receptor-independent cardiomyocyte apoptosis by serotonin and post ischemic myocardial injury publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.528133 contributor: fullname: Bianchi – volume: 34 start-page: 2187 year: 2003 ident: 10.1016/j.freeradbiomed.2015.06.025_bib41 article-title: QTc interval prolongation is a predictor of future strokes in patients with type 2 diabetes mellitus publication-title: Stroke doi: 10.1161/01.STR.0000085084.15144.66 contributor: fullname: Cardoso – volume: 8 start-page: e67009 year: 2013 ident: 10.1016/j.freeradbiomed.2015.06.025_bib5 article-title: Multiple antioxidants improve cardiac complications and inhibit cardiac cell death in streptozotocin-induced diabetic rats publication-title: PLoS One doi: 10.1371/journal.pone.0067009 contributor: fullname: Kumar – volume: 40 start-page: 405 year: 1991 ident: 10.1016/j.freeradbiomed.2015.06.025_bib3 article-title: Role of oxidative stress in development of complications in diabetes publication-title: Diabetes doi: 10.2337/diab.40.4.405 contributor: fullname: Baynes – volume: 98 start-page: 596 year: 2006 ident: 10.1016/j.freeradbiomed.2015.06.025_bib1 article-title: Diabetic cardiomyopathy: the search for a unifying hypothesis publication-title: Circ. Res. doi: 10.1161/01.RES.0000207406.94146.c2 contributor: fullname: Poornima |
SSID | ssj0004538 |
Score | 2.486662 |
Snippet | Oxidative stress is closely associated with the pathophysiology of diabetic cardiomyopathy (DCM). The mitochondrial flavoenzyme monoamine oxidase A (MAO-A) is... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 263 |
SubjectTerms | Animals Antioxidants - metabolism Apoptosis Apoptosis - drug effects Apoptosis - genetics Cardiac dysfunction Clorgyline - administration & dosage Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetic Cardiomyopathies - genetics Diabetic Cardiomyopathies - metabolism Diabetic Cardiomyopathies - pathology Diabetic cardiomyopathy Fibrosis - genetics Fibrosis - metabolism Fibrosis - pathology Free radicals Humans Lipid Peroxidation - genetics Monoamine Oxidase - drug effects Monoamine Oxidase - metabolism Monoamine oxidase A Monoamine Oxidase Inhibitors - administration & dosage Myocardial Contraction - drug effects Myocardium - metabolism Myocardium - pathology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics Rats Reactive Oxygen Species - metabolism Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - pathology |
Title | Monoamine oxidase-A is an important source of oxidative stress and promotes cardiac dysfunction, apoptosis, and fibrosis in diabetic cardiomyopathy |
URI | https://dx.doi.org/10.1016/j.freeradbiomed.2015.06.025 https://www.ncbi.nlm.nih.gov/pubmed/26122707 https://search.proquest.com/docview/1724260970 |
Volume | 87 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fa9RAEB7qFcWXoq0_ztqyovjUeElud7N5EY5iORX6ooW-LcluFlK4JDQpeC_-E_7DzuwmakFB6EsgYZIsmcnMN7vfzgC8SYyKDTdZ5IrMRNyVJlKKq0jmFgGCqoxwnm1xLtcX_NOluNyB02kvDNEqR98ffLr31uOVxfg1F11dL77EKk8wfOKBlpaW6Id3MRxxPoPd1cfP6_M_iob7htYkH9END-D1b5qXu64qWrX2m92J6iV8PU9qnf33QPUvIOoD0tkj2BuRJFuFwT6GnarZh4NVg1n0ZsveMs_t9JPm-3A_tJzcHsAP_InbYoPYkrXfaosxLFqxumdFw-qNx-LNwMKMPmtdkCGPyMKmEpSzrPMUvqpnxpuXYXbbU3wkHZ-womu7oe3r_sQLO8zH6YzVDQsTvbUJN-IwW2qIvH0CF2cfvp6uo7ExQ2REnA4RpkxGGb5EeFa6kkuRGiWllU6iv8hK46gInURgya1FhFJiyphZYZKlyVObSrF8CrOmbarnwKj_epVZg44BxQ2may4v0UiEsjwvVTIHPmlBd6H-hp6IaVf6lvI0KU8TTS8Vc3g_aUzfMieNkeL_HvBq0rPGH45WUYqmam96jYiPqvrnWTyHZ8EAfo2M6rGlWZy9uOvrD-EhnQXW4EuYDdc31RGin6E8hnvvvifHo43_BIhbByY |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEF9Kix8vRVs_Tq2uKD51vSS3u9m8CEexnFr7Ygt9W5L9gAiXhCYF78V_wn_Ymd1EW1AQfAkkN8ktmcnMb3Z_O0PI69SoxHCTM1_mhnFfGaYUV0wWFgCCckb4wLY4latz_vFCXGyRo2kvDNIqR98ffXrw1uOV-fg2511dz78kqkghfMIBl5YW4Id3EA0gr-vt9_RayfDQzhqlGYrfJq9-k7z8pXO4Zh22uiPRS4Rqntg4-89h6m8wNISj43tkd8SRdBmHep9suWaP7C8byKHXG_qGBmZnmDLfI7diw8nNPvkBn3BbrgFZ0vZbbSGCsSWte1o2tF4HJN4MNM7n09ZHGfSHNG4pATlLu0Dgcz01wbgMtZseoyNq-JCWXdsNbV_3h0HYQzaOZ7RuaJzmrU28EYbZYjvkzQNyfvz-7GjFxrYMzIgkGxgkTEYZvgBwVvmKS5EZJaWVXoK3yCvjsQSdBFjJrQV8UkHCmFth0oUpMptJsXhItpu2cY8Jxe7rLrcG3AKIG0jWfFGBiQhleVGpdEb4pAXdxeobeqKlfdU3lKdReRpJepmYkXeTxvQNY9IQJ_7tAS8nPWv43HANpWxce9VrwHtY07_Ikxl5FA3g18iwGluWJ_mT__37F-TO6uzziT75cPrpKbmLv0T-4DOyPVxeuQPAQUP1PNj5T-b_B_s |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Monoamine+oxidase-A+is+an+important+source+of+oxidative+stress+and+promotes+cardiac+dysfunction%2C+apoptosis%2C+and+fibrosis+in+diabetic+cardiomyopathy&rft.jtitle=Free+radical+biology+%26+medicine&rft.au=Umbarkar%2C+Prachi&rft.au=Singh%2C+Sarojini&rft.au=Arkat%2C+Silpa&rft.au=Bodhankar%2C+S.L.&rft.date=2015-10-01&rft.pub=Elsevier+Inc&rft.issn=0891-5849&rft.eissn=1873-4596&rft.volume=87&rft.spage=263&rft.epage=273&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2015.06.025&rft.externalDocID=S0891584915002932 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0891-5849&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0891-5849&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0891-5849&client=summon |