De novo design of protein structure and function with RFdiffusion - Watson, Joseph L.; Juergens, David; Bennett, Nathaniel R.; Trippe, Brian L.; Yim, Jason; Eisenach, Helen E.; Ahern, Woody; Borst, Andrew J.; Ragotte, Robert J.; Milles, Lukas F.; Wicky, Basile I. M.; Hanikel, Nikita; et al. (Nature (London), 2023)
Keywords: 101/28; 631/114/1305; 631/114/469; 631/45/612; 82; 82/83; Amino acid sequence; Binders; Catalytic Domain; Complexity; Cryoelectron Microscopy; Deep Learning; Design; Design specifications; Diffusion models; Electron microscopy; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - metabolism; Hemagglutinin Glycoproteins, Influenza Virus - ultrastructure; Hemagglutinins; Humanities and Social Sciences; Modelling; multidisciplinary; Protein Binding; Protein structure; Proteins; Proteins - chemistry; Proteins - metabolism; Proteins - ultrastructure; Scaffolding; Science; Science & Technology - Other Topics; Science (multidisciplinary); Structure-function relationships; Success; Topology