NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development

• Published in: Viruses Vol. 13; no. 4; p. 692
• Main Authors: Malinczak, Carrie-Anne, Schuler, Charles F., Duran, Angela J., Rasky, Andrew J., Mire, Mohamed M., Núñez, Gabriel, Lukacs, Nicholas W., Fonseca, Wendy
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.04.2021; MDPI
• Subjects: adults; Allergic diseases; Allergies; Animals; Animals, Newborn; Asthma; childhood; Children; Cytokines; Cytokines - immunology; disease severity; early-life RSV; Female; Flow cytometry; Furans - administration & dosage; Gene expression; Histology; Hypersensitivity; IL-1β; immunopathology; Indenes - administration & dosage; Infants; Infections; Inflammasomes; Inflammasomes - antagonists & inhibitors; Inflammasomes - genetics; Inflammasomes - immunology; Inflammation; Laboratories; Lung - immunology; Lung - pathology; Lung - virology; Lungs; Lymphocytes T; MCC950; Mice; Mice, Inbred BALB C; Mice, Knockout; Monocyte chemoattractant protein 1; Neonates; NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; NLRP3-inflammasome; Pathogens; Proteins; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus, Human - immunology; Respiratory tract diseases; Respiratory Tract Diseases - immunology; Respiratory Tract Diseases - prevention & control; Respiratory Tract Diseases - virology; respiratory virus; risk; Software; Sulfonamides - administration & dosage; therapeutics; viruses; β-Interferon; United States > US; MCC950; respiratory virus; lung innate viral immunity; NLRP3-inflammasome; asthma; IL-1β; early-life RSV

Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk of developing asthma later in life. Previously, our group has shown that RSV infection in mice and infants promotes IL-1β production. Here, we characterized the role o...