Dynamics of Neutralizing Antibody Responses Following Natural SARS-CoV-2 Infection and Correlation with Commercial Serologic Tests. A Reappraisal and Indirect Comparison with Vaccinated Subjects

• Published in: Viruses Vol. 13; no. 11; p. 2329
• Main Authors: Gillot, Constant, Favresse, Julien, Maloteau, Vincent, Dogné, Jean-Michel, Douxfils, Jonathan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.11.2021; MDPI
• Subjects: Accuracy; Adult; Aged; Aged, 80 and over; Antibodies; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; blood; BNT162 Vaccine - immunology; Communication; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; COVID-19 infection; COVID-19 Serological Testing - methods; COVID-19 vaccines; Epitopes; Female; Health Personnel; health services; Humans; Immunoassay; Immunogenicity, Vaccine; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Infections; Longitudinal Studies; Male; Medical personnel; Middle Aged; neutralization tests; Neutralization Tests - methods; neutralizing antibody; Patients; Polymerase chain reaction; Proteins; SARS-CoV-2; SARS-CoV-2 - immunology; Sensitivity and Specificity; Serology; Severe acute respiratory syndrome coronavirus 2; Software; Vaccination; viruses; Young Adult; United States > US; COVID-19; neutralizing antibody; SARS-CoV-2

Neutralising antibodies (NAbs) represent the real source of protection against SARS-CoV-2 infections by preventing the virus from entering target cells. The gold standard in the detection of these antibodies is the plaque reduction neutralization test (PRNT). As these experiments must be done in a v...