Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins

• Published in: The FASEB journal Vol. 31; no. 2; p. 751
• Main Authors: Cil, Onur, Phuan, Puay-Wah, Gillespie, Anne Marie, Lee, Sujin, Tradtrantip, Lukmanee, Yin, Jianyi, Tse, Ming, Zachos, Nicholas C, Lin, Ruxian, Donowitz, Mark, Verkman, Alan S
• Format: Journal Article
• Language: English
• Published: United States 01.02.2017
• Subjects: Animals; Cystic Fibrosis Transmembrane Conductance Regulator - antagonists & inhibitors; Diarrhea - chemically induced; Diarrhea - drug therapy; Dose-Response Relationship, Drug; Female; Humans; Intestines - drug effects; Mice; Molecular Structure; Oxazines - chemical synthesis; Oxazines - pharmacology; Pyrimidinones - chemical synthesis; Pyrimidinones - pharmacology; Pyrroles - chemical synthesis; Pyrroles - pharmacology; secretory diarrhea; traveler’s diarrhea; cholera; intestinal secretion

Secretory diarrheas caused by bacterial enterotoxins, including cholera and traveler's diarrhea, remain a major global health problem. Inappropriate activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel occurs in these diarrheas. We previously reported th...