Yucasin is a potent inhibitor of YUCCA, a key enzyme in auxin biosynthesis

• Published in: The Plant journal : for cell and molecular biology Vol. 77; no. 3; pp. 352 - 366
• Main Authors: Nishimura, Takeshi, Hayashi, Ken‐ichiro, Suzuki, Hiromi, Gyohda, Atsuko, Takaoka, Chihiro, Sakaguchi, Yusuke, Matsumoto, Sachiko, Kasahara, Hiroyuki, Sakai, Tatsuya, Kato, Jun‐ichi, Kamiya, Yuji, Koshiba, Tomokazu
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2014
• Subjects: Arabidopsis; Arabidopsis - drug effects; Arabidopsis - enzymology; Arabidopsis - genetics; Arabidopsis - growth & development; Arabidopsis Proteins - antagonists & inhibitors; Arabidopsis Proteins - genetics; Biosynthesis; Biosynthetic Pathways; coleoptiles; corn; Cotyledon - drug effects; Cotyledon - enzymology; Cotyledon - genetics; Cotyledon - growth & development; Dose-Response Relationship, Drug; Enzymes; Flowers & plants; Gene Expression Regulation, Plant; hypocotyls; IAA biosynthesis inhibitor; indole acetic acid; Indoleacetic Acids - chemistry; Indoleacetic Acids - metabolism; Indoles - metabolism; maize coleoptiles; mutants; Mutation; Oxygenases - antagonists & inhibitors; Oxygenases - genetics; Phenotype; plant development; Plant Growth Regulators - chemistry; Plant Growth Regulators - metabolism; Plant Leaves - drug effects; Plant Leaves - enzymology; Plant Leaves - genetics; Plant Leaves - growth & development; Plant Roots - drug effects; Plant Roots - enzymology; Plant Roots - genetics; Plant Shoots - drug effects; Plant Shoots - enzymology; Plant Shoots - genetics; Plant Shoots - growth & development; Plants, Genetically Modified; Recombinant Fusion Proteins; root growth; seedlings; Seedlings - drug effects; Seedlings - enzymology; Seedlings - genetics; Seedlings - growth & development; Small Molecule Libraries; TAA; Triazoles - chemistry; Triazoles - pharmacology; tryptophan; Tryptophan Transaminase - antagonists & inhibitors; Tryptophan Transaminase - genetics; YUCCA; Zea mays - drug effects; Zea mays - enzymology; Zea mays - genetics; Zea mays - growth & development; YUCCA; IAA biosynthesis inhibitor; maize coleoptiles; Arabidopsis; TAA; indole acetic acid

Indole‐3–acetic acid (IAA), an auxin plant hormone, is biosynthesized from tryptophan. The indole‐3–pyruvic acid (IPyA) pathway, involving the tryptophan aminotransferase TAA1 and YUCCA (YUC) enzymes, was recently found to be a major IAA biosynthetic pathway in Arabidopsis. TAA1 catalyzes the conver...