Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats
Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different dos...
Saved in:
| Published in | Clinical and experimental immunology Vol. 121; no. 1; pp. 151 - 156 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science Ltd
01.07.2000
Blackwell Oxford University Press Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different doses and phases of the disease according to several treatment protocols, but we could not observe a consistent effect of peptide T ameliorating the disease. Lymph node cell proliferation and IL‐4 and interferon‐gamma production were also studied. We conclude that peptide T neither prevents nor ameliorates EAE in Lewis rats. |
|---|---|
| AbstractList | Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different doses and phases of the disease according to several treatment protocols, but we could not observe a consistent effect of peptide T ameliorating the disease. Lymph node cell proliferation and IL‐4 and interferon‐gamma production were also studied. We conclude that peptide T neither prevents nor ameliorates EAE in Lewis rats. SUMMARY Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different doses and phases of the disease according to several treatment protocols, but we could not observe a consistent effect of peptide T ameliorating the disease. Lymph node cell proliferation and IL-4 and interferon-gamma production were also studied. We conclude that peptide T neither prevents nor ameliorates EAE in Lewis rats. |
| Author | Martínez‐Cáceres, E. M. Montalban, X. Espejo, C. Sáez‐Torres, I. Acarín, N. Pérez, J. J. |
| Author_xml | – sequence: 1 givenname: I. surname: Sáez‐Torres fullname: Sáez‐Torres, I. – sequence: 2 givenname: C. surname: Espejo fullname: Espejo, C. – sequence: 3 givenname: J. J. surname: Pérez fullname: Pérez, J. J. – sequence: 4 givenname: N. surname: Acarín fullname: Acarín, N. – sequence: 5 givenname: X. surname: Montalban fullname: Montalban, X. – sequence: 6 givenname: E. M. surname: Martínez‐Cáceres fullname: Martínez‐Cáceres, E. M. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1430580$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10886253$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkcFu1DAQhi1URLeFV0AWQogeEmwnduIDSNVqC5VWgkM5cbC8zoR65dghTuju2-N0V6VwgZM9nm9mfs9_hk588IAQpiSnpBTvtjktBM8YK2XOCCE5oYzLfPcELR4SJ2iRMjKTqeIUncW4TaEQgj1Dp5TUtWC8WKBvX6AfbQP4BjcBIvZhxLoDZ8OgR8Cw62GwHfhRO6ynMdium3x69wb6W-1Ct0_saCN-u7pcXWDr8RruUpiq43P0tNUuwovjeY6-Xq1ulp-y9eeP18vLdWY4YTJjtG4rwaiBTVWVbMMMJG2NKcqqrIqSNrXctDVlEqjRRHNDpaEN0IaKkoNkxTn6cOjbT5sOGpPUDtqpPgnXw14FbdWfGW9v1ffwU1FJuBAyNXhzbDCEHxPEUXU2GnBOewhTVBVlQlZc_BOkVV0UkpMEvvoL3IZp8GkLaahIu6_qGaoPkBlCjAO0D5IpUbPPaqtmO9Vsp5p9Vvc-q10qffn4y48KD8Ym4PUR0NFo1w7aGxt_c2VB-L2E9wfszjrY__d8tVxdz7fiF-3CxP8 |
| CODEN | CEXIAL |
| Cites_doi | 10.1001/archneur.55.1.41 10.1016/0165-5728(90)90085-2 10.1159/000150299 10.1016/S0140-6736(87)91989-1 10.1111/j.1365-2249.1995.tb03715.x 10.3109/00952999709016894 10.1016/S0165-5728(97)00213-0 10.1038/icb.1997.9 10.1016/S0192-0561(98)00020-4 10.1084/jem.172.4.1193 10.1002/ana.410360714 10.1006/clim.1999.4771 10.1016/S0192-0561(99)00041-7 10.1073/pnas.91.17.8005 10.1038/317355a0 10.1073/pnas.83.23.9254 10.1016/0165-2478(94)90132-5 10.1007/BF00686201 10.4049/jimmunol.157.12.5721 10.1097/00002030-199607000-00016 10.1016/S0165-5728(96)00220-2 10.1146/annurev.iy.10.040192.001101 10.1016/0014-5793(87)81265-6 10.1016/0190-9622(91)70249-2 10.4049/jimmunol.155.3.1556 10.1016/0165-5728(92)90134-7 10.1002/ana.410230719 10.4049/jimmunol.139.7.2329 10.1212/WNL.47.5.1254 10.3109/08830189309051211 10.1084/jem.176.3.667 10.1128/iai.43.2.580-583.1984 |
| ContentType | Journal Article |
| Copyright | 2000 INIST-CNRS Copyright Blackwell Scientific Publications Ltd. Jul 2000 2000 Blackwell Science Ltd 2000 |
| Copyright_xml | – notice: 2000 INIST-CNRS – notice: Copyright Blackwell Scientific Publications Ltd. Jul 2000 – notice: 2000 Blackwell Science Ltd 2000 |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 H94 M7N 7X8 5PM |
| DOI | 10.1046/j.1365-2249.2000.01259.x |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic AIDS and Cancer Research Abstracts MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1365-2249 |
| EndPage | 156 |
| ExternalDocumentID | 56283695 10_1046_j_1365_2249_2000_01259_x 10886253 1430580 CEI1259 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 169 1OC 24P 29B 2WC 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 5WD 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AABZA AACZT AAESR AAEVG AAHHS AAONW AAPXW AARHZ AASNB AAUAY AAVAP AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABLJU ABNHQ ABOCM ABPTD ABPVW ABQNK ABXVV ACAHQ ACCFJ ACFBH ACGFO ACGFS ACMXC ACPOU ACPRK ACSCC ACUFI ACXQS ADBBV ADEOM ADIPN ADIYS ADIZJ ADKYN ADMGS ADOZA ADQBN ADVEK ADXAS ADZMN ADZOD AEEZP AEGXH AEIMD AENEX AEQDE AEUQT AFBPY AFEBI AFFZL AFGKR AFPWT AFRAH AFXAL AFZJQ AGUTN AIACR AIAGR AIURR AIWBW AJAOE AJBDE AJEEA ALAGY ALMA_UNASSIGNED_HOLDINGS AMBMR AMYDB AOIJS ATGXG ATUGU AZBYB AZVAB BAFTC BAWUL BCRHZ BEYMZ BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EAS EBB EBC EBD EBS EBX EJD EMB EMK EMOBN ESTFP ESX EX3 F00 F01 F04 F5P FIJ FUBAC G-S G.N GODZA GX1 H.X H13 HF~ HZI HZ~ IH2 IHE IPNFZ IX1 J0M J5H K48 KBUDW KBYEO KOP KSI KSN LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NOMLY O66 O9- OAUYM OBS OCZFY OHT OIG OJZSN OK1 OPAEJ OVD OWPYF P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 Q~Q R.K ROL ROX RPM RX1 SUPJJ SV3 TEORI TR2 TUS UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOQ WOW WQJ WRC WVDHM WXI X7M XG1 Y6R YFH YOC YUY ZGI ZXP ZZTAW ~IA ~KM ~WT 08R AAPBV AAUGY AAVGM ABHUG ABPTK ABWRO ACXME ADAWD ADDAD AFVGU AGJLS ALXQX BFHJK IQODW ZA5 ABEJV AGMDO CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 H94 M7N 7X8 5PM |
| ID | FETCH-LOGICAL-c5029-218f7621ceb7742b2ce625dc34747341d89bf8129e1ca0a5c19c1de1d1645e923 |
| IEDL.DBID | RPM |
| ISSN | 0009-9104 |
| IngestDate | Tue Sep 17 21:34:01 EDT 2024 Sat Oct 26 05:42:31 EDT 2024 Fri Oct 25 03:42:24 EDT 2024 Thu Oct 10 16:32:35 EDT 2024 Fri Aug 23 02:42:55 EDT 2024 Sat Nov 02 11:58:14 EDT 2024 Sun Oct 29 17:08:15 EDT 2023 Sat Aug 24 00:50:03 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Autoimmunity Animal model Nervous system diseases Multiple sclerosis Encephalomyelitis Rat Interleukin Cytokine Rodentia Biological activity Cerebral disorder Inflammatory disease Vertebrata Octapeptide Mammalia Synthetic product Animal Central nervous system disease Spinal cord disease Gamma interferon |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5029-218f7621ceb7742b2ce625dc34747341d89bf8129e1ca0a5c19c1de1d1645e923 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905669 |
| PMID | 10886253 |
| PQID | 196862780 |
| PQPubID | 36527 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_1905669 proquest_miscellaneous_71269756 proquest_miscellaneous_17833950 proquest_journals_196862780 crossref_primary_10_1046_j_1365_2249_2000_01259_x pubmed_primary_10886253 pascalfrancis_primary_1430580 wiley_primary_10_1046_j_1365_2249_2000_01259_x_CEI1259 |
| PublicationCentury | 2000 |
| PublicationDate | July 2000 |
| PublicationDateYYYYMMDD | 2000-07-01 |
| PublicationDate_xml | – month: 07 year: 2000 text: July 2000 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England |
| PublicationTitle | Clinical and experimental immunology |
| PublicationTitleAlternate | Clin Exp Immunol |
| PublicationYear | 2000 |
| Publisher | Blackwell Science Ltd Blackwell Oxford University Press Blackwell Science Inc |
| Publisher_xml | – name: Blackwell Science Ltd – name: Blackwell – name: Oxford University Press – name: Blackwell Science Inc |
| References | 1987; 1 1993; 9 1984; 43 1997; 23 1999; 21 1992 1995; 155 1988; 75 1992; 10 1998; 84 1998; 20 1996; 10 1994; 41 1993; 35 1987; 211 1986; 83 1991; 25 1990; 26 1987; 139 1986; 9 1992; 176 1997; 75 1997; 74 1994; 36 1988; 23 1988; 24 1995; 100 1985; 317 1999; 93 1996; 47 1996; 46 1994; 91 1996; 157 1998; 55 1992; 40 1990; 172 Van der Veen (2022011221081528300_b8) 1990; 26 Pert (2022011221081528300_b25) 1988; 24 Ruff (2022011221081528300_b16) 1987; 211 Phipps (2022011221081528300_b14) 1996; 10 Buenafe (2022011221081528300_b33) 1995; 155 Raine (2022011221081528300_b4) 1992 Sáez-Torres (2022011221081528300_b26) 1998; 84 Kleinerman (2022011221081528300_b15) 1987; 139 Heber-Katz (2022011221081528300_b6) 1993; 9 Wekerle (2022011221081528300_b5) 1993; 35 Ruddle (2022011221081528300_b11) 1990; 172 Redwine (2022011221081528300_b18) 1999; 93 Phipps (2022011221081528300_b27) 1995; 100 Ruuls (2022011221081528300_b29) 1996; 157 Heseltine (2022011221081528300_b22) 1998; 55 Farber (2022011221081528300_b20) 1991; 25 Raychaudhuri (2022011221081528300_b28) 1999; 21 Lassmann (2022011221081528300_b9) 1988; 75 Kosten (2022011221081528300_b23) 1997; 23 Topham (2022011221081528300_b31) 1994; 91 Martin (2022011221081528300_b1) 1992; 10 Hartung (2022011221081528300_b10) 1992; 40 Murphy (2022011221081528300_b36) 1994; 41 Pert (2022011221081528300_b24) 1986; 9 Simpson (2022011221081528300_b21) 1996; 47 Zamvil (2022011221081528300_b7) 1985; 317 Goverman (2022011221081528300_b3) 1996; 46 Wauben (2022011221081528300_b30) 1992; 176 Wekerle (2022011221081528300_b2) 1994; 36 Raychaudhuri (2022011221081528300_b17) 1998; 20 Pert (2022011221081528300_b12) 1986; 83 Staykova (2022011221081528300_b34) 1997; 75 Davis (2022011221081528300_b35) 1984; 43 Gaur (2022011221081528300_b32) 1997; 74 Wetterberg (2022011221081528300_b19) 1987; 1 Pert (2022011221081528300_b13) 1988; 23 |
| References_xml | – volume: 211 start-page: 17 year: 1987 end-page: 22 article-title: CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide publication-title: FEBS Letters – volume: 75 start-page: 566 year: 1988 end-page: 76 article-title: Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinating lesions publication-title: Acta Neuropathol (Berl) – volume: 36 start-page: S47 year: 1994 end-page: S53 article-title: Animal models publication-title: Ann Neurol – volume: 46 start-page: 482 year: 1996 end-page: 92 article-title: Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis publication-title: Lab Anim Sci – volume: 21 start-page: 609 year: 1999 end-page: 15 article-title: Immunomodulatory effects of peptide T on Th1/Th2 cytokines publication-title: Int J Immunopharmacol – volume: 9 start-page: 277 year: 1993 end-page: 85 article-title: The ups and downs of EAE publication-title: Int Rev Immunol – volume: 1 start-page: 159 year: 1987 article-title: Peptide T in the treatment of AIDS [Letter] publication-title: Lancet – volume: 25 start-page: 658 year: 1991 end-page: 64 article-title: Peptide T improves psoriasis when infused into lesions in nanograms amounts publication-title: J Am Acad Dermatol – volume: 176 start-page: 667 year: 1992 end-page: 77 article-title: Disease inhibition by major histocompatibility complex binding peptide analogues of disease‐associated epitopes: more than blocking alone publication-title: J Exp Med – volume: 9 start-page: 482 year: 1986 end-page: 4 article-title: Peptide T [4,8]: a pentapeptide sequence in the AIDS virus envelope which blocks infectivity is essentially conserved across nine isolates publication-title: Clin Neuropharmacol – volume: 40 start-page: 197 year: 1992 end-page: 210 article-title: Inflammatory mediators in demyelinating disorders of the central nervous system and peripheral nervous system publication-title: J Neuroimmunol – volume: 139 start-page: 2329 year: 1987 end-page: 37 article-title: A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte‐mediated killing by inactivating interleukin‐1 publication-title: J Immunol – volume: 100 start-page: 412 year: 1995 end-page: 8 article-title: An octapeptide analogue of HIV gp120 modulates protein tyrosine kinase activity in activated peripheral blood T lymphocytes publication-title: Clin Exp Immunol – volume: 91 start-page: 8005 year: 1994 end-page: 9 article-title: A synthetic peptide from the third hypervariable region of major histocompatibility complex of class II β chain as a vaccine for treatment of experimental autoimmune encephalomyelitis publication-title: Proc Natl Acad Sci USA – volume: 47 start-page: 1254 year: 1996 end-page: 9 article-title: Peptide T in the treatment of painful distal neuropathy associated with AIDS. Results of a placebo‐controlled trial publication-title: Neurology – volume: 157 start-page: 5721 year: 1996 end-page: 31 article-title: The length of treatment determines whether interferon beta prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats publication-title: J Immunol – volume: 10 start-page: 153 year: 1992 end-page: 87 article-title: Immunological aspects of demyelinating diseases publication-title: Annu Rev Immunol – volume: 35 start-page: 95 year: 1993 end-page: 100 article-title: T‐cell autoimmunity in the central nervous system publication-title: Intervirology – volume: 83 start-page: 9254 year: 1986 end-page: 8 article-title: Octapeptides deduced from neuropeptide receptor‐like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T cell infectivity publication-title: Proc Natl Acad Sci USA – volume: 93 start-page: 124 year: 1999 end-page: 31 article-title: Peptide T blocks gp120/CCR5 chemokine receptor‐mediated chemotaxis publication-title: Clin Immunol – volume: 43 start-page: 580 year: 1984 end-page: 3 article-title: Genetic variation in the ability of several strains of rats to produce interferon in response to polyrioinosinic‐polyribocytodilic acid publication-title: Infect Immun – volume: 172 start-page: 1193 year: 1990 end-page: 200 article-title: An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis publication-title: J Exp Med – volume: 317 start-page: 355 year: 1985 article-title: T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination publication-title: Nature – volume: 23 start-page: 571 year: 1988 end-page: 3 article-title: AIDS and its dementia as neuropeptide disorder: role of VIP receptor blockade by HIV envelope publication-title: Ann Neurol – volume: 155 start-page: 1556 year: 1995 end-page: 64 article-title: Analysis of Vß8.2 CDR3 sequences from spinal cord T cells of Lewis rats vaccinated or treated with TCR Vß8.2‐39‐59 peptide publication-title: J Immunol – start-page: 535 year: 1992: end-page: 52 – volume: 74 start-page: 149 year: 1997 end-page: 58 article-title: Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms publication-title: J Neuroimmunol – volume: 24 start-page: 315 year: 1988 end-page: 9 article-title: AIDS as a neuropeptide disorder: peptide T, VIP, and the HIV receptor publication-title: Psycopharmacol Bull – volume: 84 start-page: 24 year: 1998 end-page: 29 article-title: Gangliosides do not elicit experimental autoimmune encephalomyelitis in Lewis rats and SJL mice publication-title: J Neuroimmunol – volume: 75 start-page: 54 year: 1997 end-page: 64 article-title: Infusion of soluble myelin basic protein protects long term against induction of experimental autoimmune encephalomyelitis publication-title: Immunol Cell Biol – volume: 23 start-page: 543 year: 1997 end-page: 53 article-title: Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T publication-title: Am J Drug Alcohol Abuse – volume: 41 start-page: 195 year: 1994 end-page: 9 article-title: T‐cell recognition of an allogeneic RT1‐db ‐class II MHC peptide publication-title: Immunol Letters – volume: 55 start-page: 41 year: 1998 end-page: 51 article-title: Randomized double‐blind placebo‐controlled trial of peptide T for HIV‐associated cognitive impairment publication-title: Arch Neurol – volume: 20 start-page: 661 year: 1998 end-page: 7 article-title: Anti‐chemotactic activities of peptide T: a possible mechanism of action for its therapeutic effects on psoriasis publication-title: Int J Immunopharmacol – volume: 10 start-page: 919 year: 1996 end-page: 20 article-title: Inhibition of tumor necrosis factor‐α explains inhibition of HIV replication by peptide T publication-title: AIDS – volume: 26 start-page: 139 year: 1990 end-page: 45 article-title: The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein publication-title: J Neuroimmunol – volume: 55 start-page: 41 year: 1998 ident: 2022011221081528300_b22 article-title: Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment publication-title: Arch Neurol doi: 10.1001/archneur.55.1.41 contributor: fullname: Heseltine – volume: 26 start-page: 139 year: 1990 ident: 2022011221081528300_b8 article-title: The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein publication-title: J Neuroimmunol doi: 10.1016/0165-5728(90)90085-2 contributor: fullname: Van der Veen – volume: 24 start-page: 315 year: 1988 ident: 2022011221081528300_b25 article-title: AIDS as a neuropeptide disorder: peptide T, VIP, and the HIV receptor publication-title: Psycopharmacol Bull contributor: fullname: Pert – volume: 35 start-page: 95 year: 1993 ident: 2022011221081528300_b5 article-title: T-cell autoimmunity in the central nervous system publication-title: Intervirology doi: 10.1159/000150299 contributor: fullname: Wekerle – volume: 1 start-page: 159 year: 1987 ident: 2022011221081528300_b19 article-title: Peptide T in the treatment of AIDS [Letter] publication-title: Lancet doi: 10.1016/S0140-6736(87)91989-1 contributor: fullname: Wetterberg – volume: 100 start-page: 412 year: 1995 ident: 2022011221081528300_b27 article-title: An octapeptide analogue of HIV gp120 modulates protein tyrosine kinase activity in activated peripheral blood T lymphocytes publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.1995.tb03715.x contributor: fullname: Phipps – volume: 23 start-page: 543 year: 1997 ident: 2022011221081528300_b23 article-title: Treatment of early AIDS dementia in intravenous drug users: high versus low dose peptide T publication-title: Am J Drug Alcohol Abuse doi: 10.3109/00952999709016894 contributor: fullname: Kosten – volume: 84 start-page: 24 year: 1998 ident: 2022011221081528300_b26 article-title: Gangliosides do not elicit experimental autoimmune encephalomyelitis in Lewis rats and SJL mice publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(97)00213-0 contributor: fullname: Sáez-Torres – volume: 75 start-page: 54 year: 1997 ident: 2022011221081528300_b34 article-title: Infusion of soluble myelin basic protein protects long term against induction of experimental autoimmune encephalomyelitis publication-title: Immunol Cell Biol doi: 10.1038/icb.1997.9 contributor: fullname: Staykova – volume: 20 start-page: 661 year: 1998 ident: 2022011221081528300_b17 article-title: Anti-chemotactic activities of peptide T: a possible mechanism of action for its therapeutic effects on psoriasis publication-title: Int J Immunopharmacol doi: 10.1016/S0192-0561(98)00020-4 contributor: fullname: Raychaudhuri – volume: 172 start-page: 1193 year: 1990 ident: 2022011221081528300_b11 article-title: An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis publication-title: J Exp Med doi: 10.1084/jem.172.4.1193 contributor: fullname: Ruddle – volume: 36 start-page: S47 year: 1994 ident: 2022011221081528300_b2 article-title: Animal models publication-title: Ann Neurol doi: 10.1002/ana.410360714 contributor: fullname: Wekerle – volume: 93 start-page: 124 year: 1999 ident: 2022011221081528300_b18 article-title: Peptide T blocks gp120/CCR5 chemokine receptor-mediated chemotaxis publication-title: Clin Immunol doi: 10.1006/clim.1999.4771 contributor: fullname: Redwine – volume: 21 start-page: 609 year: 1999 ident: 2022011221081528300_b28 article-title: Immunomodulatory effects of peptide T on Th1/Th2 cytokines publication-title: Int J Immunopharmacol doi: 10.1016/S0192-0561(99)00041-7 contributor: fullname: Raychaudhuri – volume: 91 start-page: 8005 year: 1994 ident: 2022011221081528300_b31 article-title: A synthetic peptide from the third hypervariable region of major histocompatibility complex of class II β chain as a vaccine for treatment of experimental autoimmune encephalomyelitis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.91.17.8005 contributor: fullname: Topham – volume: 317 start-page: 355 year: 1985 ident: 2022011221081528300_b7 article-title: T cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination publication-title: Nature doi: 10.1038/317355a0 contributor: fullname: Zamvil – volume: 83 start-page: 9254 year: 1986 ident: 2022011221081528300_b12 article-title: Octapeptides deduced from neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T cell infectivity publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.23.9254 contributor: fullname: Pert – volume: 41 start-page: 195 year: 1994 ident: 2022011221081528300_b36 article-title: T-cell recognition of an allogeneic RT1-dbu-class II MHC peptide publication-title: Immunol Letters doi: 10.1016/0165-2478(94)90132-5 contributor: fullname: Murphy – volume: 75 start-page: 566 year: 1988 ident: 2022011221081528300_b9 article-title: Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinating lesions publication-title: Acta Neuropathol (Berl) doi: 10.1007/BF00686201 contributor: fullname: Lassmann – volume: 157 start-page: 5721 year: 1996 ident: 2022011221081528300_b29 article-title: The length of treatment determines whether interferon beta prevents or aggravates experimental autoimmune encephalomyelitis in Lewis rats publication-title: J Immunol doi: 10.4049/jimmunol.157.12.5721 contributor: fullname: Ruuls – volume: 10 start-page: 919 year: 1996 ident: 2022011221081528300_b14 article-title: Inhibition of tumor necrosis factor-α explains inhibition of HIV replication by peptide T publication-title: AIDS doi: 10.1097/00002030-199607000-00016 contributor: fullname: Phipps – volume: 74 start-page: 149 year: 1997 ident: 2022011221081528300_b32 article-title: Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms publication-title: J Neuroimmunol doi: 10.1016/S0165-5728(96)00220-2 contributor: fullname: Gaur – volume: 10 start-page: 153 year: 1992 ident: 2022011221081528300_b1 article-title: Immunological aspects of demyelinating diseases publication-title: Annu Rev Immunol doi: 10.1146/annurev.iy.10.040192.001101 contributor: fullname: Martin – volume: 211 start-page: 17 year: 1987 ident: 2022011221081528300_b16 article-title: CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide publication-title: FEBS Letters doi: 10.1016/0014-5793(87)81265-6 contributor: fullname: Ruff – volume: 25 start-page: 658 year: 1991 ident: 2022011221081528300_b20 article-title: Peptide T improves psoriasis when infused into lesions in nanograms amounts publication-title: J Am Acad Dermatol doi: 10.1016/0190-9622(91)70249-2 contributor: fullname: Farber – volume: 155 start-page: 1556 year: 1995 ident: 2022011221081528300_b33 article-title: Analysis of Vß8.2 CDR3 sequences from spinal cord T cells of Lewis rats vaccinated or treated with TCR Vß8.2-39-59 peptide publication-title: J Immunol doi: 10.4049/jimmunol.155.3.1556 contributor: fullname: Buenafe – volume: 40 start-page: 197 year: 1992 ident: 2022011221081528300_b10 article-title: Inflammatory mediators in demyelinating disorders of the central nervous system and peripheral nervous system publication-title: J Neuroimmunol doi: 10.1016/0165-5728(92)90134-7 contributor: fullname: Hartung – volume: 23 start-page: 571 year: 1988 ident: 2022011221081528300_b13 article-title: AIDS and its dementia as neuropeptide disorder: role of VIP receptor blockade by HIV envelope publication-title: Ann Neurol doi: 10.1002/ana.410230719 contributor: fullname: Pert – volume: 9 start-page: 482 year: 1986 ident: 2022011221081528300_b24 article-title: Peptide T [4,8]: a pentapeptide sequence in the AIDS virus envelope which blocks infectivity is essentially conserved across nine isolates publication-title: Clin Neuropharmacol contributor: fullname: Pert – volume: 139 start-page: 2329 year: 1987 ident: 2022011221081528300_b15 article-title: A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin-1 publication-title: J Immunol doi: 10.4049/jimmunol.139.7.2329 contributor: fullname: Kleinerman – volume: 47 start-page: 1254 year: 1996 ident: 2022011221081528300_b21 article-title: Peptide T in the treatment of painful distal neuropathy associated with AIDS. Results of a placebo-controlled trial publication-title: Neurology doi: 10.1212/WNL.47.5.1254 contributor: fullname: Simpson – start-page: 535 volume-title: Textbook of neuropathology year: 1992: ident: 2022011221081528300_b4 article-title: Demyelinating diseases contributor: fullname: Raine – volume: 9 start-page: 277 year: 1993 ident: 2022011221081528300_b6 article-title: The ups and downs of EAE publication-title: Int Rev Immunol doi: 10.3109/08830189309051211 contributor: fullname: Heber-Katz – volume: 176 start-page: 667 year: 1992 ident: 2022011221081528300_b30 article-title: Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone publication-title: J Exp Med doi: 10.1084/jem.176.3.667 contributor: fullname: Wauben – volume: 46 start-page: 482 year: 1996 ident: 2022011221081528300_b3 article-title: Rodent models of experimental allergic encephalomyelitis applied to the study of multiple sclerosis publication-title: Lab Anim Sci contributor: fullname: Goverman – volume: 43 start-page: 580 year: 1984 ident: 2022011221081528300_b35 article-title: Genetic variation in the ability of several strains of rats to produce interferon in response to polyrioinosinic-polyribocytodilic acid publication-title: Infect Immun doi: 10.1128/iai.43.2.580-583.1984 contributor: fullname: Davis |
| SSID | ssj0006662 |
| Score | 1.6223786 |
| Snippet | Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We... SUMMARY Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in... |
| SourceID | pubmedcentral proquest crossref pubmed pascalfrancis wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 151 |
| SubjectTerms | Animals Biological and medical sciences Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control experimental autoimmune encephalomyelitis Female g-Interferon Guinea Pigs Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Lewis rat Medical sciences multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neuroimmunology Neurology peptide T Peptide T - administration & dosage Peptide T - therapeutic use Pilot Projects Rats Rats, Inbred Lew |
| SummonAdditionalLinks | – databaseName: Wiley Online Library - Core collection (SURFmarket) dbid: DR2 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Rb9MwED6hSUNIiMGAkY2BH3iAh1R1Eyf24zQ6DcQQQps0iYfIdhytGksmkgq2X8-dnXQtTAgh3traTtPLnf1d7-47gFepTEypfYRRizh1PI2N1eNYqVJYo7SQvn3b0cfs8CR9fypO-_wnqoUJ_BCLP9zIMvx-TQauTehCMvbstkOGFvoPvt5khFutUCPCkzzJKbvr7ecbJilE6ZOhqRqekGmf1NMHOG-90MpJdf9Styi0KnS7uA2O_p5VuYx2_XF1sAHnww8NWSrno3lnRvb6Fw7I_yOJh_CgR7VsL6jhI7jj6k1YD30urzbh7lEfwX8MXz5RGk3p2DErG9eyuumYvsAbIFV0bLnhANPzrplR_Qp-TsWVZ_prc3HlKGGvZa-ne9M3bFazD-47vsXV7RM4OZge7x_GfYOH2ApKu0F4UeFmzK0ziEInZmIdumOlTVJ0cvB4LaUyFSIQ5TjqjxaWK8tLx0v08YRDaPoU1uqmds-AVdJl1mmdcZ2mQhNPIs8qjvjWSpdIHQEfHmZxGXg8Ch9_T6lWjeRXkPyoK-e48PIrfkSwu_LUbxYST5ocR7AzaEHRW35b4Dejk5jT6MvFKJosxWF07Zo5Tsllkijxhxk5n2QqF1kEW0Gnlu5Z4uVFEkG-om2LCUQXvjpSz848bThCP8TuKoLMK9Nfi6HYn76jV9v_unAH7gUCA0pyfg5r3be520Uo15kX3kh_AoqNOuQ priority: 102 providerName: Wiley-Blackwell |
| Title | Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1046%2Fj.1365-2249.2000.01259.x https://www.ncbi.nlm.nih.gov/pubmed/10886253 https://www.proquest.com/docview/196862780 https://search.proquest.com/docview/17833950 https://search.proquest.com/docview/71269756 https://pubmed.ncbi.nlm.nih.gov/PMC1905669 |
| Volume | 121 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9swED7aQsdglLX75XXt9NCH7sFJZEu29VhCSluWUUYLhT0YWT7TQGKH2WHrf7-TbLcJG2PszbFk7OhOuu-47-4ATkQSZrl2EUYtfYFc-JnRI1-pXJpMaZm49m3TL9HFrbi6k3dbIPtcGEfaN9lsUM4Xg3J277iVy4UZ9jyx4fV0TEaMUIgabsM2KWjvonfHL-HxoG-fRrZQdPSdLpTpSF3kcrgUlQGdzlK1tahpt5ErEG6YpxdLXdNKFW2Liz9h0N-plOsQ19mo85ew14FLdtb-iX3YwvIAdtt2kw8H8GzaBdJfwbdry2bJkd2wvMKalVXD9ALnNmG_QbZe95_pVVPNbBoJ3bc5jvd6Xi0e0PLmanY6OZt8YrOSfcYf9JOerl_D7fnkZnzhd30WfCMt-4WsfEFnIjeYERgMssAgLUVuQkG-Blm5PFFZQUBAIScxamm4MjxHnpOrJZEQ4hvYKasS3wErEowMah1xLYTUtlwhjwpOMNMkGCbaA94vb7psy2mkLgwubMqYlU5qpWObY45SJ530pwdHG3J4etCWK0tGHhz2ckm7DVin9GaSZ2xHPz6O0s6x4RBdYrWiKXEShkr-ZUbMg0jFMvLgbSvltW9u1cWDeEP-jxNs1e7NEVJmV727U14PIqcp_7wM6Xhyaa_e__crD-F5W0jAko0_wE7zfYVHBKma7Jicia_BsdtIvwCXORu4 |
| link.rule.ids | 230,315,730,783,787,888,1378,27938,27939,46308,46732,53806,53808 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIh4S4lFeppTugQMc7GRjr-09VlGqFJKqhxRV4mCt12M1IrEj7AjKr2d2bZcEEAJujnctOzszu99ovpkBeB3EfpopG2FUwg2QB26qVd-VMhM6lUrEtn3b9DQcnwfvLsTFDoguF8aS9nU694rF0ivml5ZbuVrqXscT651Nh3SIEQqRvRtwk-y1H3ZOersBEyIfdA3U6DQMWgJPG8y0tC5yOmySikf7s5BNNWqyN3IG_K0D6t5KVbRWedPk4nco9Fcy5SbItafU8QP40P2_hpzyyVvXqae__VT68Z8X4CHcb3ErO2qGH8EOFntwq-lkebUHt6dtjP4xfDwzRJkM2YxlJVasKGumlrgwtQBqZJstBZha1-XcZKjQfZM-eakW5fIKDSWvYm9GR6O3bF6wCX6hn_R09QTOj0ez4dhtWzi4WhhiDQGInLZbrjElnDlIBxppjTPtB-TG0AGaxTLNCWNI5KQhSmguNc-QZ-TFCSTw-RR2i7LA58DyGEONSoVcBYFQphIiD3NOCFbH6MfKAd7JLVk1lToSG2EPTDaaEXtixG76bvYTK_bkqwMHWwL-8aCphBb3HdjvBJ60tl0l9GZSlMiMHl6PklGaSIsqsFzTlCj2fSn-MCPig1BGInTgWaM-G9_c6KED0ZZiXU8wBcG3R0hNbGHwVi0cCK0K_vUyJMPRibl68d-vPIQ749l0kkxOTt_vw92mXoHhNL-E3frzGg8IudXpK2un3wGl6DzL |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwED7BEBMS4seAEcaYH3iAh6R1Eyfx41RabbBOfdikCR4ix7loFW1SLalg_PWcnWS0gBDaWxo7Suq7832n-3wH8DaI_TRTNsOohBsgD9xUq74rZSZ0KpWIbfu2yWl4dB58vBAXa62-LGlfpzOvmC-8YnZpuZXLhe51PLHedDIkJ0YoRPaWWd67C_fIZvtxF6i3mzCh8kHXRI08YtCSeNqEpqV2UeBhD6p4tEcL2VSkJpujgMDfcFIPl6qi9cqbRhd_Q6J_EirXga71VOPH8Ln7jw1B5au3qlNP__it_OOtFuEJPGrxKztspjyFO1jswP2mo-X1DmxP2lz9M_gyNYSZDNkZy0qsWFHWTC1wbmoC1MjWWwswtarLmTmpQvfNMcpLNS8X12ioeRV7NzocvWezgp3gN_pJT1fP4Xw8OhseuW0rB1cLQ7AhIJHTtss1poQ3B-lAI61zpv2AwhlypFks05ywhkROmqKE5lLzDHlG0ZxAAqEvYKsoC3wJLI8x1KhUyFUQCGUqIvIw54RkdYx-rBzgneySZVOxI7GZ9sCcSjOiT4zoTf_NfmJFn3x3YH9DyL8eNBXR4r4De53Qk9bGq4TeTMoSmdGDm1EyTpNxUQWWK5oSxb4vxT9mRHwQykiEDuw2KrT2zY0uOhBtKNfNBFMYfHOEVMUWCG9Vw4HQquF_L0MyHB2bq1e3fuUBbE8_jJOT49NPe_CgKVtgqM2vYau-WuE-Abg6fWNN9SeqRz9L |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Peptide+T+does+not+ameliorate+experimental+autoimmune+encephalomyelitis+%28EAE%29+in+Lewis+rats&rft.jtitle=Clinical+and+experimental+immunology&rft.au=S%C3%A1ez-Torres%2C+I&rft.au=Espejo%2C+C&rft.au=P%C3%A9rez%2C+J+J&rft.au=Acar%C3%ADn%2C+N&rft.date=2000-07-01&rft.pub=Blackwell+Science+Inc&rft.issn=0009-9104&rft.eissn=1365-2249&rft.volume=121&rft.issue=1&rft.spage=151&rft.epage=156&rft_id=info:doi/10.1046%2Fj.1365-2249.2000.01259.x&rft_id=info%3Apmid%2F10886253&rft.externalDBID=PMC1905669 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-9104&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-9104&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-9104&client=summon |