Xeroderma pigmentosum clinical practice guidelines

• Published in: Journal of dermatology Vol. 44; no. 10; pp. 1087 - 1096
• Main Authors: Moriwaki, Shinichi, Kanda, Fumio, Hayashi, Masaharu, Yamashita, Daisuke, Sakai, Yoshitada, Nishigori, Chikako
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.10.2017
• Subjects: Adult; Child; Children; Clinical medicine; Clinical practice guidelines; Dermatology - standards; Diagnosis, Differential; DNA repair; DNA Repair - radiation effects; Genetic Testing; Humans; Japan; Neurocutaneous Syndromes - etiology; Neurocutaneous Syndromes - prevention & control; neurological symptoms; Patient Care - methods; photoaging; Photosensitivity; Prognosis; Quality of Life; Severity of Illness Index; Skin; Skin - radiation effects; Skin cancer; skin cancers; Skin Neoplasms - etiology; Skin Neoplasms - prevention & control; Societies, Medical - standards; Sunlight - adverse effects; Ultraviolet radiation; Ultraviolet Rays - adverse effects; Xeroderma pigmentosum; Xeroderma Pigmentosum - complications; Xeroderma Pigmentosum - diagnosis; Xeroderma Pigmentosum - genetics; Xeroderma Pigmentosum - therapy; Japan; neurological symptoms; xeroderma pigmentosum; skin cancers; DNA repair; photoaging

Xeroderma pigmentosum (XP) is a genetic photosensitive disorder in which patients are highly susceptibe to skin cancers on the sun‐exposed body sites. In Japan, more than half of patients (30% worldwide) with XP show complications of idiopathic progressive, intractable neurological symptoms with poo...