IGF‐1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA‐1 and microRNA‐133a

• Published in: Journal of cellular and molecular medicine Vol. 16; no. 1; pp. 83 - 95
• Main Authors: Hua, Yinan, Zhang, Yingmei, Ren, Jun
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2012; John Wiley & Sons, Inc
• Subjects: Abdomen; AKT protein; Animals; Antibodies; Aorta; Atrial natriuretic peptide; Biomarkers - metabolism; Cardiac function; cardiac hypertrophy; Cardiomegaly - pathology; Cardiomegaly - physiopathology; Cardiomyocytes; Cell proliferation; Cell surface; Cells, Cultured; Coronary vessels; Cytology; Echocardiography; Gene expression; Glucose transporter; Glycogen; Glycogen synthase kinase 3; Heart failure; Heart Failure - pathology; Heart Failure - physiopathology; Heart Ventricles - pathology; Heart Ventricles - physiopathology; Hypertrophy; IGF‐1; Immunohistochemistry; Insulin-like growth factor I; Insulin-Like Growth Factor I - deficiency; Insulin-like growth factors; Kinases; Mice; Mice, Inbred C57BL; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Muscle contraction; myocardial contraction; Myocardial Contraction - physiology; Myocytes, Cardiac - cytology; Myocytes, Cardiac - metabolism; Neonates; Original; Phosphorylation; Physiology; Protein deficiency; Protein phosphatase; Protein transport; Proteins; Rapamycin; Rats; TOR protein; Transfection; Ventricle; United States > US
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/j.1582-4934.2011.01307.x

This study was designed to examine the impact of insulin‐like growth factor‐1 (IGF‐1) deficiency on abdominal aortic constriction (AAC)‐induced cardiac geometric and functional changes with a focus on microRNA‐1, 133a and 208, which are specially expressed in hearts and govern cardiac hypertrophy an...