The Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis

• Published in: Cell Vol. 158; no. 1; pp. 98 - 109
• Main Authors: Yelagandula, Ramesh, Stroud, Hume, Holec, Sarah, Zhou, Keda, Feng, Suhua, Zhong, Xuehua, Muthurajan, Uma M., Nie, Xin, Kawashima, Tomokazu, Groth, Martin, Luger, Karolin, Jacobsen, Steven E., Berger, Frédéric
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 03.07.2014
• Subjects: Amino Acid Sequence; Animalia; animals; Arabidopsis; Arabidopsis - genetics; Arabidopsis - metabolism; Arabidopsis Proteins - chemistry; Arabidopsis Proteins - genetics; Arabidopsis Proteins - metabolism; Chromatin Assembly and Disassembly; chromosome segregation; DNA Methylation; DNA Transposable Elements; gene expression; genome; Genome-Wide Association Study; heterochromatin; Heterochromatin - metabolism; histones; Histones - chemistry; Histones - genetics; Histones - metabolism; Metazoa; Molecular Sequence Data; plants (botany); Sequence Alignment; transposons

Histone variants play crucial roles in gene expression, genome integrity, and chromosome segregation. We report that the four H2A variants in Arabidopsis define different genomic features, contributing to overall genomic organization. The histone variant H2A.W marks heterochromatin specifically and...