Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

• Published in: Critical care medicine Vol. 47; no. 11; p. e919
• Main Authors: Stortz, Julie A, Hollen, McKenzie K, Nacionales, Dina C, Horiguchi, Hiroyuki, Ungaro, Ricardo, Dirain, Marvin L, Wang, Zhongkai, Wu, Quran, Wu, Kevin K, Kumar, Ashok, Foster, Thomas C, Stewart, Brian D, Ross, Julia A, Segal, Marc, Bihorac, Azra, Brakenridge, Scott, Moore, Frederick A, Wohlgemuth, Stephanie E, Leeuwenburgh, Christiaan, Mohr, Alicia M, Moldawer, Lyle L, Efron, Philip A
• Format: Journal Article
• Language: English
• Published: United States 01.11.2019
• Subjects: Age Factors; Animals; Cecum - surgery; Chemokines - blood; Cytokines - blood; Disease Models, Animal; Female; Humans; Immune Tolerance - physiology; Inflammation - mortality; Inflammation - pathology; Kaplan-Meier Estimate; Ligation - adverse effects; Ligation - methods; Male; Mice; Mice, Inbred C57BL; Multiple Organ Failure - mortality; Multiple Organ Failure - pathology; Postoperative Complications - mortality; Postoperative Complications - pathology; Random Allocation; Risk Factors; Sepsis - mortality; Sepsis - pathology; Survival Analysis; Weight Loss - physiology

Our goal was to "reverse translate" the human response to surgical sepsis into the mouse by modifying a widely adopted murine intra-abdominal sepsis model to engender a phenotype that conforms to current sepsis definitions and follows the most recent expert recommendations for animal precl...