Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model - Stortz, Julie A; Hollen, McKenzie K; Nacionales, Dina C; Horiguchi, Hiroyuki; Ungaro, Ricardo; Dirain, Marvin L; Wang, Zhongkai; Wu, Quran; Wu, Kevin K; Kumar, Ashok; Foster, Thomas C; Stewart, Brian D; et al. (Critical care medicine, 2019)
Keywords: Age Factors; Animals; Cecum - surgery; Chemokines - blood; Cytokines - blood; Disease Models, Animal; Female; Humans; Immune Tolerance - physiology; Inflammation - mortality; Inflammation - pathology; Kaplan-Meier Estimate; Ligation - adverse effects; Ligation - methods; Male; Mice; Mice, Inbred C57BL; Multiple Organ Failure - mortality; Multiple Organ Failure - pathology; Postoperative Complications - mortality; Postoperative Complications - pathology; Random Allocation; Risk Factors; Sepsis - mortality; Sepsis - pathology; Survival Analysis; Weight Loss - physiology