Defibrillatory action of glibenclamide is independent from ATP-sensitive K+ channels and free radicals

• Published in: Journal of cardiovascular pharmacology Vol. 41; no. 6; p. 916
• Main Authors: Csonka, Csaba, Onody, Annamária, Csont, Tamás, Ferdinandy, Péter
• Format: Journal Article
• Language: English
• Published: United States 01.06.2003
• Subjects: Adenosine Triphosphate - metabolism; Animals; Anti-Arrhythmia Agents - pharmacology; Anti-Arrhythmia Agents - therapeutic use; Chromatography, High Pressure Liquid; Coronary Circulation - drug effects; Cromakalim - pharmacology; Electric Stimulation; Glyburide - pharmacology; Glyburide - therapeutic use; Heart Rate - drug effects; Hydroxyl Radical - metabolism; In Vitro Techniques; Male; Potassium Channel Blockers - pharmacology; Potassium Channels - drug effects; Potassium Channels - physiology; Rats; Rats, Wistar; Superoxides - metabolism; Vasodilator Agents - pharmacology; Ventricular Fibrillation - drug therapy; Ventricular Fibrillation - metabolism; Ventricular Fibrillation - physiopathology

This study investigated whether glibenclamide exerts a defibrillatory action and if this action is mediated by a blockade of ATP-sensitive K+ channels (K(ATP)) or by an anti-free radical mechanism. Aerobically perfused isolated rat hearts were subjected to 10 min of pacing-induced ventricular fibril...