Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function

• Published in: Critical care medicine Vol. 48; no. 5; p. e418
• Main Authors: Doran, Sarah J, Henry, Rebecca J, Shirey, Kari Ann, Barrett, James P, Ritzel, Rodney M, Lai, Wendy, Blanco, Jorge C, Faden, Alan I, Vogel, Stefanie N, Loane, David J
• Format: Journal Article
• Language: English
• Published: United States 01.05.2020
• Subjects: Animals; Brain Injuries, Traumatic - epidemiology; Brain Injuries, Traumatic - physiopathology; Disease Models, Animal; Inflammation Mediators - metabolism; Male; Mice; Mice, Inbred C57BL; Monocytes - metabolism; Pneumonia, Staphylococcal; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - mortality; Staphylococcal Infections - epidemiology; Staphylococcal Infections - mortality

Respiratory infections in the postacute phase of traumatic brain injury impede optimal recovery and contribute substantially to overall morbidity and mortality. This study investigated bidirectional innate immune responses between the injured brain and lung, using a controlled cortical impact model...