Prion disease causes less severe lesions in human hippocampus than other parts of brain

• Published in: Psychiatry and clinical neurosciences Vol. 62; no. 3; pp. 264 - 270
• Main Authors: Kaneko, Minoru, Sugiyama, Nobuhiro, Sasayama, Daimei, Yamaoka, Keiko, Miyakawa, Tomohiro, Arima, Kunimasa, Tsuchiya, Kuniaki, Hasegawa, Kazuko, Washizuka, Shinsuke, Hanihara, Tokisi, Amano, Naoji, Yagishita, Saburo
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.06.2008; Blackwell Publishing
• Subjects: Adult; Aged; Biological and medical sciences; Cerebral Cortex - pathology; Creutzfeldt-Jakob Syndrome - pathology; Creutzfeldt–Jakob disease; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; dementia; Dominance, Cerebral - physiology; Entorhinal Cortex - pathology; Female; Gerstmann-Straussler-Scheinker Disease - genetics; Gerstmann-Straussler-Scheinker Disease - pathology; Gerstmann–Sträussler–Scheinker syndrome; Gliosis - pathology; hippocampus; Hippocampus - pathology; Humans; Male; Medical sciences; Middle Aged; Neurology; Neurons - pathology; Parahippocampal Gyrus - pathology; prion; Prion Diseases - pathology; Prions - analysis; Prions - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Human; Nervous system diseases; Prion disease; Central nervous system; Creutzfeldt-Jakob disease; Cerebral disorder; Encephalon; Infection; Gerstmann-Straussler-Scheinker syndrome; Gerstmann-Sträussler-Scheinker syndrome; Central nervous system disease; Degenerative disease; Prion; Lesion; Hippocampus; Dementia

Aim:  The hippocampus can be very sensitive to damage in the scrapie‐infected mouse, a well‐established animal model of prion diseases. Terminally ill scrapie‐infected animals exhibit nearly complete loss of cornu ammonis (CA) 1 pyramidal neurons, but few studies have focused on the neuropathologica...