Serum creatinine is a biomarker of progressive denervation in spinal muscular atrophy

• Published in: Neurology Vol. 94; no. 9; p. e921
• Main Authors: Alves, Christiano R R, Zhang, Ren, Johnstone, Alec J, Garner, Reid, Nwe, Pann H, Siranosian, Jennifer J, Swoboda, Kathryn J
• Format: Journal Article
• Language: English
• Published: United States 03.03.2020
• Subjects: Action Potentials - physiology; Biomarkers - blood; Cell Count; Child; Creatinine - blood; Disease Progression; DNA Copy Number Variations - genetics; Female; Humans; Infant; Male; Motor Neurons - pathology; Muscle, Skeletal - physiology; Muscular Atrophy, Spinal - blood; Muscular Atrophy, Spinal - diagnosis; Muscular Atrophy, Spinal - genetics; Nerve Degeneration - blood; Nerve Degeneration - diagnosis; Predictive Value of Tests; Severity of Illness Index; Survival of Motor Neuron 2 Protein - genetics

Identifying simple biomarkers that can predict or track disease progression in patients with spinal muscular atrophy (SMA) remains an unmet clinical need. To test the hypothesis that serum creatinine (Crn) could be a prognostic biomarker for monitoring progression of denervation in patients with SMA...