Local energy depletion in the basal forebrain increases sleep

• Published in: The European journal of neuroscience Vol. 17; no. 4; pp. 863 - 869
• Main Authors: Kalinchuk, Anna V., Urrila, Anna-Sofia, Alanko, Lauri, Heiskanen, Silja, Wigren, Henna-Kaisa, Suomela, Maricel, Stenberg, Dag, Porkka-Heiskanen, Tarja
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science, Ltd 01.02.2003
• Subjects: 2,4-Dinitrophenol - pharmacology; adenosine; Adenosine - metabolism; Analysis of Variance; Animals; basal forebrain; Chromatography, High Pressure Liquid - methods; Circadian Rhythm - physiology; Dose-Response Relationship, Drug; Electroencephalography - methods; Energy Metabolism - drug effects; Energy Metabolism - physiology; Enzyme Inhibitors - pharmacology; Lactic Acid - metabolism; local energy depletion; Male; Microdialysis - methods; non-REM sleep; Potassium Cyanide - pharmacology; Prosencephalon - drug effects; Prosencephalon - metabolism; Pyruvic Acid - metabolism; Rats; Sleep - drug effects; Sleep - physiology; sleep deprivation; Sleep Deprivation - metabolism; Sleep Stages - drug effects; Sleep Stages - physiology; Uncoupling Agents - pharmacology

Sleep saves energy, but can brain energy depletion induce sleep? We used 2,4‐dinitrophenol (DNP), a molecule which prevents the synthesis of ATP, to induce local energy depletion in the basal forebrain of rats. Three‐hour DNP infusions induced elevations in extracellular concentrations of lactate, p...