Relationship between 5‐fluorouracil exposure and outcome in patients receiving continuous venous infusion with or without concomitant radiotherapy - Beneton, Maud; Chapet, Sophie; Blasco, Hélène; Giraudeau, Bruno; Boisdron‐Celle, Michèle; Deporte‐Fety, Régine; Denis, Fabrice; Narcisso, Bérangère; Calais, Gilles; Le Guellec, Chantal (British journal of clinical pharmacology, 2007)
Keywords: 5‐fluorouracil; Antineoplastic agents; Biological and medical sciences; Carcinoma, Squamous Cell - drug therapy; Carcinoma, Squamous Cell - radiotherapy; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; drug monitoring; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Fluorouracil - pharmacokinetics; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - radiotherapy; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - pharmacokinetics; Male; Medical sciences; pharmacokinetics; Pharmacokinetics and Pharmacodynamics; Pharmacology. Drug treatments; Pilot Projects; Treatment Outcome; Antineoplastic agent; Prognosis; Intravenous administration; Continuous; Toxicity; drug monitoring; Therapeutic drug monitoring; Activity concentration relation; ENT disease; Fluorouracil; Human; Enzyme; Fluoropyrimidine derivatives; Transferases; Enzyme inhibitor; Malignant tumor; Thymidylate synthase; Radiotherapy; 5-fluorouracil; Chemotherapy; Antimetabolic; Methyltransferases; Perfusion; Pyrimidine derivatives; Head and neck cancer; Combined treatment; Pharmacokinetics