The impact of CYP2D6 polymorphisms on the pharmacokinetics of codeine and its metabolites in Mongolian Chinese subjects

• Published in: European journal of clinical pharmacology Vol. 70; no. 1; pp. 57 - 63
• Main Authors: Wu, Xiujun, Yuan, Li, Zuo, Jinliang, Lv, Jing, Guo, Tao
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2014; Springer; Springer Nature B.V
• Subjects: Administration, Oral; Adult; Alleles; Analgesics; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Area Under Curve; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Codeine - blood; Codeine - pharmacokinetics; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; Female; Genotype; Humans; Kinetics; Male; Medical sciences; Metabolites; Mongolia; Morphine - blood; Morphine Derivatives - blood; Narcotics; Neuropharmacology; Pharmacokinetics and Disposition; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Polymorphism; Polymorphism, Genetic; Young Adult; Morphine; Pharmacokinetics; Polymorphism; Codeine; Human; Genetic variability; Enzyme; Isozyme; Metabolite; Cytochrome P450; Opiates; Genotype; Antitussive agent; Narcotic analgesic; CYP2D6; Polymorphism CYP2D6 10; Chinese; Cytochrome CYP2D6

Purpose Codeine is an analgesic drug acting on μ-opioid receptors predominantly via its metabolite morphine formed almost exclusively by CYP2D6 . Genetic polymorphisms in CYP2D6 are associated with diminished pain relief and/or severe opioid side effects. In Chinese individuals, CYP2D6*10 is the mos...