Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation

• Published in: Nature cell biology Vol. 21; no. 3; pp. 359 - 371
• Main Authors: Jung, Hae-Yun, Fattet, Laurent, Tsai, Jeff H., Kajimoto, Taketoshi, Chang, Qiang, Newton, Alexandra C., Yang, Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2019; Nature Publishing Group
• Subjects: 13/106; 13/51; 14; 14/105; 14/19; 631/80/84/2176; 631/80/84/2336; 631/80/85; 64; 64/110; 64/60; 692/699/67/1347; 82; 82/51; 96/95; Adaptor Proteins, Signal Transducing - metabolism; Analysis; Animals; Biodegradation; Breast cancer; Caco-2 Cells; Cancer; Cancer metastasis; Cancer Research; Carcinoma; Cell Biology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell physiology; Cell Polarity; Cytological research; Degradation; Development and progression; Developmental Biology; Epithelial-Mesenchymal Transition; Female; Health aspects; Humans; Kinases; Life Sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mesenchyme; Metastases; Metastasis; Mice, Inbred BALB C; Mice, Nude; Mice, Transgenic; Multiprotein Complexes - metabolism; Neoplasm Metastasis; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Organoids; Phosphorylation; Physiological aspects; Polarity; Protein kinase C; Protein Kinase C - metabolism; Protein kinases; Proteins; Proteolysis; RNA Interference; Snail Family Transcription Factors - genetics; Snail Family Transcription Factors - metabolism; Snail protein; Stem Cells; Tetracyclines; Transcription factors; Transplantation, Heterologous; Tumors; Xenografts; Xenotransplantation

Loss of apical–basal polarity and activation of epithelial–mesenchymal transition (EMT) both contribute to carcinoma progression and metastasis. Here, we report that apical–basal polarity inhibits EMT to suppress metastatic dissemination. Using mouse and human epithelial three-dimensional organoid c...