Semaphorin-Plexin Signaling Guides Patterning of the Developing Vasculature

• Published in: Developmental cell Vol. 7; no. 1; pp. 117 - 123
• Main Authors: Torres-Vázquez, Jesús, Gitler, Aaron D, Fraser, Sherri D, Berk, Jason D, Van N. Pham, Fishman, Mark C, Childs, Sarah, Epstein, Jonathan A, Weinstein, Brant M
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2004
• Subjects: Animals; Blood Vessels - cytology; Blood Vessels - embryology; Blood Vessels - metabolism; Body Patterning - genetics; Cell Line; Danio rerio; Gene Expression Regulation, Developmental - genetics; Humans; Membrane Glycoproteins - genetics; Membrane Glycoproteins - isolation & purification; Membrane Glycoproteins - metabolism; Mice; Molecular Sequence Data; Mutation - genetics; Neovascularization, Physiologic - genetics; Nerve Tissue Proteins - genetics; Receptors, Cell Surface - genetics; Receptors, Cell Surface - isolation & purification; Receptors, Cell Surface - metabolism; Semaphorins - genetics; Semaphorins - metabolism; Signal Transduction - genetics; Signal Transduction - physiology; Somites - cytology; Somites - metabolism; Zebrafish; Zebrafish Proteins - genetics; Zebrafish Proteins - isolation & purification; Zebrafish Proteins - metabolism

Major vessels of the vertebrate circulatory system display evolutionarily conserved and reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In the nervous system, axonal pathways are shaped by repulsive cues provided by ligands of the semaphorin family that are sen...