Biosynthesis and function of gliotoxin in Aspergillus fumigatus

• Published in: Applied microbiology and biotechnology Vol. 93; no. 2; pp. 467 - 472
• Main Authors: Scharf, Daniel H., Heinekamp, Thorsten, Remme, Nicole, Hortschansky, Peter, Brakhage, Axel A., Hertweck, Christian
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.01.2012; Springer Nature B.V
• Subjects: Apoptosis; Aspergillus fumigatus; Aspergillus fumigatus - genetics; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - pathogenicity; biochemical pathways; Biomedical and Life Sciences; Biosynthesis; Biosynthetic Pathways; Biosynthetic Pathways - genetics; Biotechnology; Cytochrome; disulfide bonds; Enzymes; Fungi; Genes; genetics; Genomes; Gliotoxin; Gliotoxin - biosynthesis; Immune response; Immunosuppressive Agents; Immunosuppressive Agents - metabolism; Life Sciences; metabolism; Metabolites; Microbial Genetics and Genomics; Microbiology; Mini-Review; mycotoxins; NMR; Nuclear magnetic resonance; pathogenicity; Peptides; Proteins; prototypes; Studies; Sulfur; toxicity; Toxins; Transcription factors; Virulence; Virulence Factors; Virulence Factors - biosynthesis; Germany; Non-ribosomal peptide biosynthesis; ETP toxins; Gliotoxin

Gliotoxin (GT) is the prototype of the epidithiodioxopiperazine (ETP)-type fungal toxins. GT plays a critical role in the pathobiology of Aspergillus fumigatus . It modulates the immune response and induces apoptosis in different cell types. The toxicity has been attributed to the unusual intramolec...