Preparation, properties and challenges of the microneedles-based insulin delivery system

• Published in: Journal of controlled release Vol. 288; pp. 173 - 188
• Main Authors: Chen, Xiang, Wang, Li, Yu, Haojie, Li, Chengjiang, Feng, Jingyi, Haq, Fazal, Khan, Amin, Khan, Rizwan Ullah
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.10.2018
• Subjects: Diabetes; Glucose-responsive microneedle; Hydrogel; Insulin; Microneedle fabrication; pain; phase transition; Phase transition microneedle; polymers; Skin; subcutaneous injection; Microneedle fabrication; Skin; Phase transition microneedle; Diabetes; Hydrogel; Insulin; Glucose-responsive microneedle

Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their sp...