Preparation, properties and challenges of the microneedles-based insulin delivery system

Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their sp...

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Published inJournal of controlled release Vol. 288; pp. 173 - 188
Main Authors Chen, Xiang, Wang, Li, Yu, Haojie, Li, Chengjiang, Feng, Jingyi, Haq, Fazal, Khan, Amin, Khan, Rizwan Ullah
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 28.10.2018
Subjects
Diabetes
Glucose-responsive microneedle
Hydrogel
Insulin
Microneedle fabrication
pain
phase transition
Phase transition microneedle
polymers
Skin
subcutaneous injection
Microneedle fabrication
Skin
Phase transition microneedle
Diabetes
Hydrogel
Insulin
Glucose-responsive microneedle
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Summary:Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review. [Display omitted]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0168-3659
1873-4995
1873-4995
DOI:10.1016/j.jconrel.2018.08.042