Preparation, properties and challenges of the microneedles-based insulin delivery system

Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their sp...

Full description

Saved in:
Bibliographic Details
Published inJournal of controlled release Vol. 288; pp. 173 - 188
Main Authors Chen, Xiang, Wang, Li, Yu, Haojie, Li, Chengjiang, Feng, Jingyi, Haq, Fazal, Khan, Amin, Khan, Rizwan Ullah
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 28.10.2018
Subjects
Diabetes
Glucose-responsive microneedle
Hydrogel
Insulin
Microneedle fabrication
pain
phase transition
Phase transition microneedle
polymers
Skin
subcutaneous injection
Microneedle fabrication
Skin
Phase transition microneedle
Diabetes
Hydrogel
Insulin
Glucose-responsive microneedle
Online AccessGet full text

Cover

Abstract Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review. [Display omitted]
AbstractList Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review.
Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review. [Display omitted]
Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review.Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across the skin. This process does not affect the activity of insulin. Compared to subcutaneous injection, microneedles cause less pain for their special structure. This review thoroughly discusses the preparation technologies of the microneedles-based insulin delivery system including solid, hollow, dissolving, phase transition, glucose-responsive microneedle patches. In the meantime, the properties, challenges and clinical/commercial status of the microneedles-based insulin delivery system are also discussed in this review.
Author Khan, Rizwan Ullah
Yu, Haojie
Wang, Li
Feng, Jingyi
Khan, Amin
Li, Chengjiang
Haq, Fazal
Chen, Xiang
Author_xml – sequence: 1
  givenname: Xiang
  surname: Chen
  fullname: Chen, Xiang
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
– sequence: 2
  givenname: Li
  orcidid: 0000-0001-9356-9930
  surname: Wang
  fullname: Wang, Li
  email: opl_wl@dial.zju.edu.cn
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
– sequence: 3
  givenname: Haojie
  surname: Yu
  fullname: Yu, Haojie
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
– sequence: 4
  givenname: Chengjiang
  surname: Li
  fullname: Li, Chengjiang
  organization: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, PR China
– sequence: 5
  givenname: Jingyi
  surname: Feng
  fullname: Feng, Jingyi
  organization: The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, PR China
– sequence: 6
  givenname: Fazal
  surname: Haq
  fullname: Haq, Fazal
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
– sequence: 7
  givenname: Amin
  surname: Khan
  fullname: Khan, Amin
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
– sequence: 8
  givenname: Rizwan Ullah
  orcidid: 0000-0003-1706-5495
  surname: Khan
  fullname: Khan, Rizwan Ullah
  organization: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30189223$$D View this record in MEDLINE/PubMed
BookMark eNqNkUtrGzEUhUVJqJ20P6FhlllkHL1mRkMXIYQ0LQSSRQvdCT3u1DIajSvJAf_7yLWbRTYJXLhc-M7hcs4JOgpTAIS-ELwgmLSXq8XKTCGCX1BMxAKX4fQDmhPRsZr3fXOE5oUTNWubfoZOUlphjBvGu49oxoqkp5TN0e_HCGsVVXZTuKjWcVpDzA5SpYKtzFJ5D-FPOaehykuoRmdi-QOsh1RrlcBWLqSNd6Gy4N0TxG2VtinD-AkdD8on-HzYp-jXt9ufN9_r-4e7HzfX97VpMMm1VUYoYs1gheGgG631wDjQXrTYkI5bIiwMjIJtle16LEBpLShhtAHba8NO0fnet_z-dwMpy9ElA96rANMmSUoa1lIuePcOFBPakR7Tgp4d0I0ewcp1dKOKW_k_uAI0e6DkkVKE4QUhWO4Kkit5KEjuCpK4DN8Zf32lMy7_Sz9H5fyb6qu9GkqiTw6iTMZBMGBdBJOlndwbDs_l9LGT
CitedBy_id crossref_primary_10_1016_j_jcis_2024_05_045
crossref_primary_10_1016_j_jconrel_2020_06_039
crossref_primary_10_1021_acsabm_4c00399
crossref_primary_10_1016_j_matpr_2023_05_239
crossref_primary_10_1039_D3BM00262D
crossref_primary_10_1016_j_jconrel_2024_02_023
crossref_primary_10_1016_j_ijpharm_2025_125206
crossref_primary_10_1016_j_jconrel_2020_02_014
crossref_primary_10_1080_00914037_2022_2042290
crossref_primary_10_1002_app_49772
crossref_primary_10_1007_s10965_024_04007_2
crossref_primary_10_1016_j_jconrel_2025_01_069
crossref_primary_10_1016_j_ijpharm_2024_124220
crossref_primary_10_2174_1570159X20666221012142247
crossref_primary_10_1002_cnma_202100288
crossref_primary_10_1016_j_carbpol_2020_116314
crossref_primary_10_3390_v14050964
crossref_primary_10_1016_j_jddst_2025_106841
crossref_primary_10_1080_10717544_2023_2296350
crossref_primary_10_3389_fbioe_2024_1468423
crossref_primary_10_1016_j_apsb_2020_08_016
crossref_primary_10_3390_biomimetics8010050
crossref_primary_10_1016_j_actbio_2020_12_004
crossref_primary_10_1016_j_drudis_2022_103393
crossref_primary_10_3390_pharmaceutics15010277
crossref_primary_10_3390_pharmaceutics14061152
crossref_primary_10_1016_j_carbpol_2021_118168
crossref_primary_10_1016_j_eurpolymj_2021_110829
crossref_primary_10_1039_D1TB00880C
crossref_primary_10_1002_anbr_202200126
crossref_primary_10_1016_j_msec_2019_05_002
crossref_primary_10_1016_j_jconrel_2024_03_001
crossref_primary_10_1007_s00170_021_06674_7
crossref_primary_10_1088_2057_1976_ad43f0
crossref_primary_10_1016_j_jconrel_2023_07_001
crossref_primary_10_1016_j_jddst_2024_105930
crossref_primary_10_1016_j_colsurfb_2022_112818
crossref_primary_10_1021_acsbiomaterials_1c01073
crossref_primary_10_1021_acsmaterialslett_3c00287
crossref_primary_10_1016_j_eurpolymj_2021_110348
crossref_primary_10_1016_j_ijbiomac_2024_131650
crossref_primary_10_1016_j_ijpharm_2019_118741
crossref_primary_10_1021_acs_iecr_1c01277
crossref_primary_10_2174_1567201818666210720145706
crossref_primary_10_1007_s00216_020_02971_4
crossref_primary_10_1016_j_ijpharm_2025_125474
crossref_primary_10_1016_j_jconrel_2022_10_059
crossref_primary_10_3389_fimmu_2021_660974
crossref_primary_10_1016_j_ajps_2021_07_002
crossref_primary_10_1016_j_colsurfb_2023_113636
crossref_primary_10_1016_j_medntd_2023_100253
crossref_primary_10_1021_acsbiomaterials_0c00273
crossref_primary_10_1002_adem_202100503
crossref_primary_10_22159_ajpcr_2022_v15i2_43572
crossref_primary_10_1016_j_jconrel_2023_11_029
crossref_primary_10_1016_j_jddst_2020_102007
crossref_primary_10_2174_1567201816666190201143457
crossref_primary_10_1002_adtp_201900036
crossref_primary_10_1016_j_ijpharm_2021_120749
crossref_primary_10_1016_j_ejps_2023_106518
crossref_primary_10_1016_j_mtbio_2022_100508
crossref_primary_10_1016_j_jconrel_2019_10_049
crossref_primary_10_1016_j_biopha_2024_117219
crossref_primary_10_1016_j_eurpolymj_2022_111217
crossref_primary_10_1016_j_ijbiomac_2024_130301
crossref_primary_10_1016_j_ijbiomac_2024_137064
crossref_primary_10_1016_j_jmapro_2020_02_024
crossref_primary_10_1002_cnm_3812
crossref_primary_10_1016_j_carbpol_2024_122885
crossref_primary_10_1007_s13346_021_01077_3
crossref_primary_10_1021_acsbiomaterials_9b00532
crossref_primary_10_1016_j_jconrel_2019_05_029
crossref_primary_10_3390_pharmaceutics11060256
crossref_primary_10_1016_j_ijpharm_2024_125072
crossref_primary_10_1093_jpp_rgad058
crossref_primary_10_1016_j_jddst_2021_102336
crossref_primary_10_1021_acsbiomaterials_3c00137
crossref_primary_10_1039_D0TB01822H
crossref_primary_10_3389_fbioe_2020_00827
crossref_primary_10_1016_j_ijbiomac_2022_10_274
crossref_primary_10_1007_s13346_023_01297_9
crossref_primary_10_1007_s12274_020_3273_z
crossref_primary_10_1007_s13346_023_01486_6
crossref_primary_10_1016_j_ijbiomac_2025_141963
crossref_primary_10_1021_acsami_3c16540
crossref_primary_10_1016_j_ejps_2021_106075
crossref_primary_10_3390_pharmaceutics13010100
crossref_primary_10_1016_j_jddst_2019_101216
crossref_primary_10_3390_ph15070877
crossref_primary_10_1016_j_jconrel_2019_10_022
crossref_primary_10_1021_acsbiomaterials_2c01123
crossref_primary_10_3390_pharmaceutics15051407
crossref_primary_10_1016_j_engreg_2022_09_002
crossref_primary_10_1007_s13346_021_00981_y
crossref_primary_10_1016_j_cclet_2022_108103
crossref_primary_10_1002_admt_202202124
crossref_primary_10_1016_j_nantod_2021_101127
crossref_primary_10_1038_s41428_021_00525_8
crossref_primary_10_1007_s13346_024_01542_9
crossref_primary_10_1016_j_bios_2021_113384
crossref_primary_10_1016_j_apsb_2021_03_003
crossref_primary_10_1007_s13346_021_00909_6
crossref_primary_10_1016_j_actbio_2020_12_023
crossref_primary_10_1016_j_eurpolymj_2021_110651
crossref_primary_10_2174_2210681213666230516155253
crossref_primary_10_1016_j_nantod_2023_101853
crossref_primary_10_3390_gels8020074
crossref_primary_10_1016_j_vaccine_2023_02_040
crossref_primary_10_1016_j_cej_2021_131913
Cites_doi 10.1080/17425247.2016.1232247
10.1021/acs.nanolett.6b03848
10.1016/j.ejpb.2013.10.007
10.1016/j.jddst.2018.03.021
10.1116/1.4960715
10.1109/JMEMS.2003.809959
10.1016/j.msec.2016.12.111
10.1002/jps.1120
10.1088/0960-1317/23/8/085011
10.1002/advs.201600124
10.1109/JMEMS.2012.2203790
10.1080/14737167.2018.1485100
10.1007/s10544-005-3024-7
10.1073/pnas.2331316100
10.1016/j.jconrel.2012.01.003
10.1073/pnas.1505405112
10.1089/dia.2013.0388
10.1016/j.msec.2014.12.010
10.1021/js980042+
10.1007/s11095-011-0524-4
10.1089/dia.2010.0183
10.1016/j.sna.2003.11.008
10.1016/j.ijpharm.2012.06.047
10.1021/acs.molpharmaceut.5b00807
10.1007/s10544-018-0262-z
10.1016/j.addr.2003.10.023
10.1109/TBME.2006.889173
10.1088/0960-1317/20/6/064006
10.1039/C7TB02082A
10.2337/diabetes.52.11.2790
10.1016/S0169-409X(98)00073-8
10.1002/mame.201500016
10.1177/193229681200600403
10.1016/j.ijpharm.2010.03.041
10.1088/0960-1317/16/10/041
10.1016/j.msec.2016.10.063
10.1007/s10544-012-9717-9
10.1177/1932296815604438
10.1016/j.jconrel.2017.05.029
10.1007/s10439-015-1466-5
10.1038/ncomms4364
10.1088/0960-1317/22/1/015016
10.1002/adma.201506025
10.1089/dia.2008.0103
10.1038/s41467-017-01764-1
10.1080/10611860600785080
10.1038/414799a
10.1016/S0928-0987(01)00167-1
10.1109/TBME.2005.845240
10.1007/s10856-009-3923-x
10.3390/pharmaceutics7030090
10.1016/j.ijpharm.2005.10.016
10.1002/smll.201200441
10.1166/jbn.2017.2474
10.1016/j.nano.2011.05.017
10.1016/j.sna.2012.04.037
10.1021/acsnano.6b06892
10.1089/dia.2016.0156
10.1002/adma.200902418
10.1109/JMEMS.2003.809951
10.1088/0960-1317/20/2/025024
10.1039/C7TB02236K
10.1007/s11095-016-1885-5
10.1016/j.jconrel.2016.08.031
10.1002/jps.23921
10.1021/jp0608168
10.1016/j.jddst.2018.01.004
10.1021/ja00995a002
10.1023/A:1013607400040
10.1177/1932296814530060
10.1023/B:PHAM.0000029282.44140.2e
10.1016/j.jconrel.2017.11.048
10.1016/j.biopha.2017.07.019
10.1097/AJP.0b013e31816778f9
10.1016/j.ejpb.2017.04.018
10.1364/OE.18.017967
10.1016/j.msec.2017.12.006
10.1002/adfm.201500554
10.1039/c3cs60436e
10.1089/dia.2012.0096
10.1016/j.jconrel.2005.02.002
10.1016/j.jconrel.2017.02.011
10.1016/S0140-6736(17)30575-5
10.3390/s131216672
10.1089/15209150152607132
10.1007/s13346-015-0239-x
10.1177/193229680900300211
10.1109/JMEMS.2011.2174429
10.1016/j.biomaterials.2007.12.048
10.1021/acs.biomac.5b00185
10.1002/adma.200701205
10.1049/mnl.2012.0903
10.1016/j.sna.2010.06.011
10.1159/000093050
10.1038/nm.2182
10.1088/0960-1317/25/2/025013
10.1021/ja972053v
10.1016/j.ejps.2015.02.018
10.1080/15321799208018377
10.1016/j.ejpb.2016.03.009
10.1016/j.ejps.2006.05.011
10.1016/j.actbio.2015.06.021
10.1080/03639040902882280
10.1088/1742-6596/34/1/187
10.1088/0960-1317/16/3/001
10.1002/anie.201106252
10.1016/j.vaccine.2017.10.021
10.3109/10717541003667798
10.1088/0960-1317/14/11/005
10.1089/dia.2010.0184
10.1007/s13346-015-0238-y
10.1023/A:1009980412628
10.1016/j.addr.2012.04.003
10.1016/j.jconrel.2012.05.030
10.1128/CVI.00387-06
10.1089/dia.2010.0204
10.1021/ma9907587
10.1016/S0169-409X(02)00114-X
10.1097/DSS.0000000000000924
10.1109/JMEMS.2014.2307320
10.1016/j.addr.2018.03.011
10.1007/s11095-012-0946-7
10.1007/BF03353783
10.1109/JMEMS.2005.844843
10.1016/j.ijbiomac.2017.07.178
10.1039/C6RA26759A
10.1016/j.mser.2016.03.001
10.1016/j.jconrel.2009.05.031
10.1111/pedi.12031
10.1111/exd.12579
10.1016/j.msec.2011.06.010
10.1016/S0167-9317(00)00363-4
10.1016/j.ijpharm.2012.07.035
10.1016/j.addr.2018.01.015
10.1039/C6RA27476E
10.1002/adhm.201300312
10.1016/j.drudis.2017.10.013
10.1117/1.JBO.20.6.061102
10.1016/j.jconrel.2017.03.015
10.1007/s10544-009-9337-1
10.1039/C5RA04340A
10.1016/j.actbio.2013.06.029
10.1088/0960-1317/20/4/045011
10.1088/1742-6596/34/1/030
10.1016/j.ijbiomac.2017.12.027
10.1002/smll.201202075
10.3109/03639045.2011.576426
10.1016/j.msec.2017.05.143
10.1002/adfm.201200864
10.1002/jbm.a.35869
ContentType Journal Article
Copyright 2018 Elsevier B.V.
Copyright © 2018 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2018 Elsevier B.V.
– notice: Copyright © 2018 Elsevier B.V. All rights reserved.
DBID AAYXX
CITATION
NPM
7X8
7S9
L.6
DOI 10.1016/j.jconrel.2018.08.042
DatabaseName CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA
PubMed

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1873-4995
EndPage 188
ExternalDocumentID 30189223
10_1016_j_jconrel_2018_08_042
S0168365918305169
Genre Journal Article
Review
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
9JM
AABNK
AABXZ
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AATCM
AAXUO
ABFNM
ABFRF
ABJNI
ABMAC
ABOCM
ABYKQ
ABZDS
ACDAQ
ACGFO
ACGFS
ACIUM
ACRLP
ADBBV
ADEZE
AEBSH
AEFWE
AEKER
AENEX
AEZYN
AFKWA
AFRZQ
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AIEXJ
AIKHN
AITUG
AJOXV
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BKOJK
BLXMC
C45
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HMT
IHE
J1W
KOM
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OVD
OZT
P-8
P-9
P2P
PC.
Q38
RIG
RNS
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SPC
SPCBC
SSM
SSP
SSZ
T5K
TEORI
~G-
.GJ
29K
3O-
AAHBH
AAQXK
AATTM
AAXKI
AAYOK
AAYWO
AAYXX
ABWVN
ABXDB
ACNNM
ACRPL
ACVFH
ADCNI
ADMUD
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AHHHB
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
ASPBG
AVWKF
AZFZN
BNPGV
CITATION
D-I
FEDTE
FGOYB
G-2
HVGLF
HZ~
R2-
SEW
SPT
SSH
WUQ
NPM
7X8
7S9
L.6
ID FETCH-LOGICAL-c501t-dac8a1dcfd8c4eb5bbbf34e29860c174d18def32ed6ad7908eabb821325ed9bc3
IEDL.DBID .~1
ISSN 0168-3659
1873-4995
IngestDate Fri Jul 11 08:24:03 EDT 2025
Fri Jul 11 02:07:40 EDT 2025
Wed Feb 19 02:35:06 EST 2025
Tue Jul 01 04:04:43 EDT 2025
Thu Apr 24 22:54:25 EDT 2025
Fri Feb 23 02:33:28 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords Microneedle fabrication
Skin
Phase transition microneedle
Diabetes
Hydrogel
Insulin
Glucose-responsive microneedle
Language English
License Copyright © 2018 Elsevier B.V. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c501t-dac8a1dcfd8c4eb5bbbf34e29860c174d18def32ed6ad7908eabb821325ed9bc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ORCID 0000-0001-9356-9930
0000-0003-1706-5495
PMID 30189223
PQID 2101271902
PQPubID 23479
PageCount 16
ParticipantIDs proquest_miscellaneous_2153624847
proquest_miscellaneous_2101271902
pubmed_primary_30189223
crossref_primary_10_1016_j_jconrel_2018_08_042
crossref_citationtrail_10_1016_j_jconrel_2018_08_042
elsevier_sciencedirect_doi_10_1016_j_jconrel_2018_08_042
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-10-28
PublicationDateYYYYMMDD 2018-10-28
PublicationDate_xml – month: 10
  year: 2018
  text: 2018-10-28
  day: 28
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Journal of controlled release
PublicationTitleAlternate J Control Release
PublicationYear 2018
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Steinert, Acker, Krause, Oswald, Wetzig (bb0270) 2006; 110
Wang, Wester, Rajaraman, Paik, Kim, Allen (bb0465) 2009; 2009
Donnelly, Larraneta (bb0810) 2018; 23
Chen, Ling, Wang, Lin, Lai, Chen (bb0725) 2015; 16
Krauland, Guggi, Bernkop-Schnurch (bb0015) 2006; 307
Yu, Zhang, Ye, Disanto, Sun, Ranson, Ligler, Buse, Gu (bb0200) 2015; 112
Mangelsdorf, Otberg, Maibach, Sinkgraven, Sterry (bb0165) 2006; 19
Yung, Xu, Kang, Liu, Tam, Ko, Kwan, Lee (bb0490) 2012; 22
Ito, Kashiwara, Fukushima, Takada (bb0570) 2011; 37
Martanto, Davis, Holiday, Wang, Gill, Prausnitz (bb0070) 2004; 21
Jin, Han, Lee, Choi (bb0330) 2009; 11
Wheeler, Heels, Donaghue, Reith, Ambler (bb0040) 2014; 16
Jepps, Dancik, Anissimov, Roberts (bb0115) 2013; 65
Sullivan, Murthy, Prausnitz (bb0550) 2008; 20
Prausnitz (bb0055) 2004; 56
Hassan, Peppas (bb0650) 2000; 33
Park, Yoon, Choi, Prausnitz, Allen (bb0305) 2007; 54
Hultstrom, Roxhed, Nordquist (bb0135) 2014; 8
Matriano, Cormier, Johnson, Young, Buttery, Nyam, Daddona (bb0750) 2002; 19
23, Aug, 2018.
Kochba, Levin, Raz, Cahn (bb0790) 2016; 18
Ita (bb0130) 2015; 7
Lau, Fei, Liu, Chen, Liu (bb0580) 2016; 265
Henry, McAllister, Allen, Prausnitz (bb0120) 1998; 87
Ita (bb0320) 2018; 44
Garland, Caffarel-Salvador, Migalska, Woolfson, Donnelly (bb0565) 2012; 159
Barry (bb0140) 2001; 14
Zhao, Coulman, Hanna, Wong, Dayan, Birchall (bb0215) 2017; 265
Kim, Lee (bb0420) 2007; Vol. 13
Yan, Raphael, Zhu, Wang, Chen, Tang, Deng, Sant, Zhu, Choy, Gale, Prow, Chen (bb0255) 2014; 3
Ito, Hirono, Fukushima, Sugioka, Takada (bb0585) 2012; 436
Xiang, Wang, Murugappan, Yen, Pastorin, Lee (bb0365) 2015; 25
Zhang, Wei (bb0345) 2011; 26
Xu, Jiang, Yu, Liu, Zhang, Zhou, Sun, Liu (bb0680) 2017; 5
Bhandari, Negi, Rieth, Solzbacher (bb0260) 2010; 162
Bogdanov, Peredkov (bb0295) 2000; 53
Demir, Metin, Satiroglu, Solmaz, Kayser, Maeder (bb0630) 2017; 117
Rouphael, Paine, Mosley, Henry, McAllister, Kalluri, Pewin, Frew, Yu, Thornburg, Kabbani, Lai, Vassilieva, Skountzou, Compans, Mulligan, Prausnitz, Grp (bb0805) 2017; 390
You, Chang, Ju, Pak (bb0535) 2011; 31
Ye, Yu, Wang, Nguyen, Walker, Buse, Gu (bb0675) 2016; 28
Gittard, Ovsianikov, Monteiro-Riviere, Lusk, Morel, Minghetti, Lenardi, Chichkov, Narayan (bb0315) 2009; 3
Raja, MacCorkle, Diwan, Abdurrob, Lu, Omenetto, Kaplan (bb0665) 2013; 9
Pettis, Ginsberg, Hirsch, Sutter, Keith, McVey, Harvey, Hompesch, Nosek, Kapitza, Heinemann (bb0800) 2011; 13
Lim, Vines, Park, Lee (bb0065) 2018; 110
Chandrasekaran, Brazzle, Frazier (bb0425) 2003; 12
Yin, Kuang, Wang, Zheng, Yadavalli, Lu (bb0660) 2017; 106
Held, Gaspar, Ruther, Hagner, Cismak, Heilmann, Paul (bb0285) 2010; 20
Brazzle, Papautsky, Frazier (bb0430) 2000; 2
Lee, Park, Prausnitz (bb0530) 2008; 29
Jurcicek, Zou, Zhang, Liu (bb0460) 2013; 8
Hong, Wu, Chen, Wu, Wei, Yuan (bb0620) 2014; 6
Jin, Zhu, Chen, Ashfaq, Guo (bb0780) 2018; 127
Liu, Jin, Quan, Kamiyama, Katsumi, Sakane, Yamamoto (bb0180) 2012; 161
Montheard, Chatzopoulos, Chappard (bb0645) 1992; C32
Gill, Denson, Burris, Prausnitz (bb0515) 2008; 24
Ito, Yamazaki, Sugioka, Takada (bb0540) 2010; 21
Flaten, Palac, Engesland, Filipović-Grčić, Vanić, Škalko-Basnet (bb0125) 2015; 75
Chen, Tian, Xu, Yung, Wang, Liu, Ni, Zhang, Zhou, Wang, Niu, Ma, Fu, Chen (bb0210) 2017; 8
Perennes, Marmiroli, Matteucci, Tormen, Vaccari, Di Fabrizio (bb0485) 2006; 16
Chen, Zhu, Zheng, Mou, Wan, Zhang, Shi, Zhao, Xu, Yang (bb0380) 2009; 139
Sensu, Sekiguchi, Kono (bb0340) 2006
S.J. Moon, C.Y. Jin, S.S. Lee, A novel method of microneedle array fabrication using inclined deep X-ray exposure, in: International Mems Conference 2006, 2006, pp. 180–186.
Yu, Jiang, Liu, Li, Chen, Liu, Huang, Tong, Yao, Kong (bb0075) 2017; 71
Lee, Lee, Lee, Jung (bb0300) 2010; 22
Danso, Berkers, Mieremet, Hausil, Bouwstra (bb0105) 2015; 24
Lee, Wu, Tsai, Chen, Wu (bb0600) 2017; 7
Griffin, Elliott, Krauer, Davies, Skinner, Anderson, Forster (bb0235) 2017; 35
Yuzhakov (bb0765) 2010
Richter-Johnson, Kumar, Choonara, du Toit, Pillay (bb0815) 2018; 18
Miyano, Tobinaga, Kanno, Matsuzaki, Takeda, Wakui, Hanada (bb0090) 2005; 7
Thennadil, Rennert, Wenzel, Hazen, Ruchti, Block (bb0700) 2001; 3
Ito, Nakahigashi, Yoshimoto, Ueda, Hamasaki, Takada (bb0610) 2012; 14
Qiu, Qin, Zhang, Wu, Xu, Gao (bb0370) 2012; 437
Rini, McVey, Sutter, Keith, Kurth, Nosek, Kapitza, Rebrin, Hirsch, Pettis (bb0825) 2015; 5
Panda, Bissoyi, Pramanik, Biswas (bb0670) 2015; 48
Guo, Wang (bb0030) 2017; 14
Ita (bb0525) 2017; 93
Larraneta, McCrudden, Courtenay, Donnelly (bb0045) 2016; 33
Norman, Choi, Tong, Aiyar, Patel, Prausnitz, Allen (bb0405) 2013; 15
Zhang, Jiang, Yu, Liu, Xu (bb0575) 2018; 85
Yu, Jiang, Zhang, Liu, Xu, Zhou (bb0730) 2017; 5
Donnelly, Mooney, McCrudden, Vicente-Perez, Belaid, Gonzalez-Vazquez, McElnay, Woolfson (bb0085) 2014; 103
Ling, Chen (bb0185) 2013; 9
Li, Zhang, Chen, Wang, Guo (bb0175) 2017; 7
Brandts, Hunt (bb0710) 1967; 89
Mansoor, Liu, Haefeli, Stoeber (bb0400) 2013; 23
Chen, Ling, Kusuma (bb0605) 2015; 24
(bb0760) 23, Aug, 2018
Park, Allen, Prausnitz (bb0335) 2005; 104
Pettis, Hirsch, Kapitza, Nosek, Hovelmann, Kurth, Sutter, Harvey, Heinemann (bb0835) 2011; 13
Lu (bb0375) 2004; 19
Shikida, Hasada, Sato (bb0415) 2006; 16
Lee, Lin, Shu, Tsai, Chen, Tsai (bb0615) 2017; 105
McVey, Hirsch, Sutter, Kapitza, Dellweg, Clair, Rebrin, Judge, Pettis (bb0795) 2012; 6
Zhang, Brown, Siebenaler, Determan, Dohmeier, Hansen (bb0745) 2012; 29
Wang, Zhao, Wang, Li (bb0280) 2012; 21
Ito, Yoshimitsu, Shiroyama, Sugioka, Takada (bb0555) 2006; 14
Mo, Jiang, Di, Tai, Gu (bb0020) 2014; 43
Eltayib, Brady, Caffarel-Salvador, Gonzalez-Vazquez, Alkilani, McCarthy, McElnay, Donnelly (bb0655) 2016; 102
Deng, Chen, Zhao, Yan, Zhang, Choy, Hu, Sant, Gale, Tang (bb0250) 2016; 6
McCarley, Bunge (bb0150) 2001; 90
Mo, Jiang, Disanto, Tai, Gu (bb0690) 2014; 5
Ita (bb0060) 2018; 45
Bouwstra, Honeywell-Nguyen (bb0100) 2002; 54
Davis, Martanto, Allen, Prausnitz (bb0390) 2005; 52
Omatsu, Chujo, Miyamoto, Okida, Nakamura, Aoki, Morita (bb0230) 2010; 18
Pfutzner, Sachsenheimer, Grenningloh, Heschel, Walther-Johannesen, Gharabli, Klonoff (bb0035) 2015; 9
Gupta, Felner, Prausnitz (bb0820) 2009; 11
Hardy, Larraneta, Donnelly, McGoldrick, Migalska, McCrudden, Irwin, Donnelly, McCoy (bb0640) 2016; 13
Bhatnagar, Dave, Venuganti (bb0785) 2017; 260
Andrews, Jeong, Prausnitz (bb0110) 2013; 30
Tsuchiya, Jinnin, Yamamoto, Uetsuji, Nakamachi (bb0225) 2010; 34
Donnelly, Singh, Garland, Migalska, Majithiya, McCrudden, Kole, Mahmood, McCarthy, Woolfson (bb0385) 2012; 22
J. Ji, F.E.H. Tay, J. Miao, Microfabricated hollow microneedle array using ICP etcher, in: International Mems Conference 2006, 2006, pp. 1132–1136.
McAllister, Wang, Davis, Park, Canatella, Allen, Prausnitz (bb0475) 2003; 100
Li, Ma, Huh, Lahiji, Lee, Jung (bb0160) 2017; 27
Wang, Huang, Guo, Xu, Yang, Zhang (bb0830) 2017; 28
Sullivan, Koutsonanos, Martin, Lee, Zarnitsyn, Choi, Murthy, Compans, Skountzou, Prausnitz (bb0560) 2010; 16
Larraneta, Lutton, Woolfson, Donnelly (bb0740) 2016; 104
Wang, Wang, Li (bb0355) 2016; 16
Chaudhri, Ceyssens, De Moor, Van Hoof, Puers (bb0470) 2010; 20
Lin, Ko, Chiou, Duann, Huang, Liang, Chiu, Jung (bb0275) 2008; 96
Khanna, Luongo, Strom, Bhansali (bb0435) 2010; 20
Justin, Roman, Chen, Tao, Geng, Grant, MacNeil, Sun, Chen (bb0025) 2015; 5
Yan, Liu, Shen, Yang (bb0410) 2012; Vol. 18
Matsumoto, Ishii, Nishida, Matsumoto, Kataoka, Miyahara (bb0705) 2012; 51
Yoon, Lee, Yoo, Lee (bb0240) 2013; 13
Mansoor, Hafeli, Stoeber (bb0480) 2012; 21
Boyne, Silver, Kaplan, Saudek (bb0695) 2003; 52
Gupta, Felner, Prausnitz (bb0080) 2011; 13
Hou, Cohen, Haimovic, Elbuluk (bb0735) 2017; 43
Rzhevskiy, Singh, Donnelly, Anissimov (bb0195) 2018; 270
Shikida, Ando, Ishihara, Ando, Sato, Asaumi (bb0265) 2004; 14
Yu, Jiang, Zhang, Liu, Xu, Zhou (bb0595) 2017; 80
Ito, Hagiwara, Saeki, Sugioka, Takada (bb0095) 2006; 29
Wallqvist, Covell, Thirumalai (bb0715) 1998; 120
O'Mahony, Pini, Blake, Webster, O'Brien, McCarthy (bb0350) 2012; 186
Stoeber, Liepmann (bb0450) 2005; 14
Hinchcliffe, Illum (bb0050) 1999; 35
Choi, Kim, Jang, Youn, Ryu (bb0325) 2012; 8
Zhang, A. Campbell, Karthikeyan (bb0495) 2018; 20
Hu, Yu, Qian, Lu, Kahkoska, Xie, Jing, Buse, Gu (bb0205) 2017; 11
Li, Li, Liu, Cui, Yu (bb0245) 2016; 44
Saravanakumar, Kim, Kim (bb0720) 2017; 4
Ma, Xia, Wang, Ren, Luo, Song, Chen, Chen, Jin (bb0220) 2016; 34
Donnelly, Singh, Woolfson (bb0145) 2010; 17
Ye, Yu, Wen, Kahkoska, Gu (bb0520) 2018; 127
Zhou, Liu, Wang, Zhang, Zhang (bb0190) 2010; 392
Qin, Gao, Wu, Zhang, Qiu, Li, Xu (bb0155) 2012; 8
Mukerjee, Collins, Isseroff, Smith (bb0455) 2004; 114
van der Maaden, Luttge, Vos, Bouwstra, Kersten, Ploemen (bb0290) 2015; 5
Ma, Wu (bb0510) 2017; 251
Hao, Li, Zhou, Yang, Qian (bb0360) 2017; 13
Griss, Stemme (bb0445) 2003; 12
Wang, Paik, Kim, Allen (bb0500) 2014; 23
Yu, Jiang, Liu, Li, Tong, Yao, Kong (bb0590) 2017; 73
Saltiel, Kahn (bb0010) 2001; 414
Kanr, Ita, Popova, Parikh, Bair (bb0170) 2014; 86
Donnelly, Morrow, Singh, Migalska, McCarron, O'Mahony, Woolfson (bb0545) 2009; 35
Yu, Qian, Zhang, Cui, Zhu, Shen, Ligler, Buse, Gu (bb0685) 2017; 17
Larraneta, Lutton, Brady, Vicente-Perez, Woolfson, Thakur, Donnelly (bb0635) 2015; 300
Yang, Wu, Liu, Fan, Welsh, Zhu, Jin (bb0625) 2015; 25
Yuen, Liu (bb0505) 2015; 20
Norman, Brown, Raviele, Prausnitz, Felner (bb0395) 2013; 14
Alarcon, Hartley, Harvey, Mikszta (bb0755) 2007; 14
Ita (10.1016/j.jconrel.2018.08.042_bb0060) 2018; 45
Wang (10.1016/j.jconrel.2018.08.042_bb0830) 2017; 28
Ma (10.1016/j.jconrel.2018.08.042_bb0220) 2016; 34
Choi (10.1016/j.jconrel.2018.08.042_bb0325) 2012; 8
Norman (10.1016/j.jconrel.2018.08.042_bb0395) 2013; 14
Ito (10.1016/j.jconrel.2018.08.042_bb0585) 2012; 436
Kanr (10.1016/j.jconrel.2018.08.042_bb0170) 2014; 86
Zhang (10.1016/j.jconrel.2018.08.042_bb0345) 2011; 26
Ma (10.1016/j.jconrel.2018.08.042_bb0510) 2017; 251
Gupta (10.1016/j.jconrel.2018.08.042_bb0080) 2011; 13
Steinert (10.1016/j.jconrel.2018.08.042_bb0270) 2006; 110
Ito (10.1016/j.jconrel.2018.08.042_bb0610) 2012; 14
Sullivan (10.1016/j.jconrel.2018.08.042_bb0550) 2008; 20
Garland (10.1016/j.jconrel.2018.08.042_bb0565) 2012; 159
10.1016/j.jconrel.2018.08.042_bb0775
Jepps (10.1016/j.jconrel.2018.08.042_bb0115) 2013; 65
Ito (10.1016/j.jconrel.2018.08.042_bb0555) 2006; 14
Chen (10.1016/j.jconrel.2018.08.042_bb0380) 2009; 139
Yuzhakov (10.1016/j.jconrel.2018.08.042_bb0765) 2010
Jin (10.1016/j.jconrel.2018.08.042_bb0780) 2018; 127
Ito (10.1016/j.jconrel.2018.08.042_bb0570) 2011; 37
Demir (10.1016/j.jconrel.2018.08.042_bb0630) 2017; 117
Ling (10.1016/j.jconrel.2018.08.042_bb0185) 2013; 9
Kochba (10.1016/j.jconrel.2018.08.042_bb0790) 2016; 18
Wang (10.1016/j.jconrel.2018.08.042_bb0355) 2016; 16
Chaudhri (10.1016/j.jconrel.2018.08.042_bb0470) 2010; 20
Alarcon (10.1016/j.jconrel.2018.08.042_bb0755) 2007; 14
Boyne (10.1016/j.jconrel.2018.08.042_bb0695) 2003; 52
Yu (10.1016/j.jconrel.2018.08.042_bb0595) 2017; 80
Hassan (10.1016/j.jconrel.2018.08.042_bb0650) 2000; 33
10.1016/j.jconrel.2018.08.042_bb0005
Lee (10.1016/j.jconrel.2018.08.042_bb0600) 2017; 7
Ita (10.1016/j.jconrel.2018.08.042_bb0130) 2015; 7
Li (10.1016/j.jconrel.2018.08.042_bb0245) 2016; 44
Ye (10.1016/j.jconrel.2018.08.042_bb0675) 2016; 28
Hinchcliffe (10.1016/j.jconrel.2018.08.042_bb0050) 1999; 35
Andrews (10.1016/j.jconrel.2018.08.042_bb0110) 2013; 30
Barry (10.1016/j.jconrel.2018.08.042_bb0140) 2001; 14
Xiang (10.1016/j.jconrel.2018.08.042_bb0365) 2015; 25
10.1016/j.jconrel.2018.08.042_bb0770
Justin (10.1016/j.jconrel.2018.08.042_bb0025) 2015; 5
Yu (10.1016/j.jconrel.2018.08.042_bb0730) 2017; 5
Pettis (10.1016/j.jconrel.2018.08.042_bb0835) 2011; 13
Ito (10.1016/j.jconrel.2018.08.042_bb0095) 2006; 29
Yin (10.1016/j.jconrel.2018.08.042_bb0660) 2017; 106
McVey (10.1016/j.jconrel.2018.08.042_bb0795) 2012; 6
Donnelly (10.1016/j.jconrel.2018.08.042_bb0385) 2012; 22
Martanto (10.1016/j.jconrel.2018.08.042_bb0070) 2004; 21
Hong (10.1016/j.jconrel.2018.08.042_bb0620) 2014; 6
Pfutzner (10.1016/j.jconrel.2018.08.042_bb0035) 2015; 9
Bhandari (10.1016/j.jconrel.2018.08.042_bb0260) 2010; 162
Yang (10.1016/j.jconrel.2018.08.042_bb0625) 2015; 25
Hultstrom (10.1016/j.jconrel.2018.08.042_bb0135) 2014; 8
Qiu (10.1016/j.jconrel.2018.08.042_bb0370) 2012; 437
Prausnitz (10.1016/j.jconrel.2018.08.042_bb0055) 2004; 56
Thennadil (10.1016/j.jconrel.2018.08.042_bb0700) 2001; 3
Lin (10.1016/j.jconrel.2018.08.042_bb0275) 2008; 96
Lee (10.1016/j.jconrel.2018.08.042_bb0300) 2010; 22
Qin (10.1016/j.jconrel.2018.08.042_bb0155) 2012; 8
Zhao (10.1016/j.jconrel.2018.08.042_bb0215) 2017; 265
Xu (10.1016/j.jconrel.2018.08.042_bb0680) 2017; 5
Larraneta (10.1016/j.jconrel.2018.08.042_bb0635) 2015; 300
Bouwstra (10.1016/j.jconrel.2018.08.042_bb0100) 2002; 54
Held (10.1016/j.jconrel.2018.08.042_bb0285) 2010; 20
Chen (10.1016/j.jconrel.2018.08.042_bb0210) 2017; 8
Perennes (10.1016/j.jconrel.2018.08.042_bb0485) 2006; 16
Rini (10.1016/j.jconrel.2018.08.042_bb0825) 2015; 5
Flaten (10.1016/j.jconrel.2018.08.042_bb0125) 2015; 75
Liu (10.1016/j.jconrel.2018.08.042_bb0180) 2012; 161
Zhang (10.1016/j.jconrel.2018.08.042_bb0575) 2018; 85
Griffin (10.1016/j.jconrel.2018.08.042_bb0235) 2017; 35
Wang (10.1016/j.jconrel.2018.08.042_bb0280) 2012; 21
Larraneta (10.1016/j.jconrel.2018.08.042_bb0740) 2016; 104
Saltiel (10.1016/j.jconrel.2018.08.042_bb0010) 2001; 414
Gill (10.1016/j.jconrel.2018.08.042_bb0515) 2008; 24
Donnelly (10.1016/j.jconrel.2018.08.042_bb0085) 2014; 103
Miyano (10.1016/j.jconrel.2018.08.042_bb0090) 2005; 7
Yu (10.1016/j.jconrel.2018.08.042_bb0075) 2017; 71
Raja (10.1016/j.jconrel.2018.08.042_bb0665) 2013; 9
Chen (10.1016/j.jconrel.2018.08.042_bb0725) 2015; 16
Larraneta (10.1016/j.jconrel.2018.08.042_bb0045) 2016; 33
Ita (10.1016/j.jconrel.2018.08.042_bb0525) 2017; 93
Chen (10.1016/j.jconrel.2018.08.042_bb0605) 2015; 24
Pettis (10.1016/j.jconrel.2018.08.042_bb0800) 2011; 13
Lim (10.1016/j.jconrel.2018.08.042_bb0065) 2018; 110
Hardy (10.1016/j.jconrel.2018.08.042_bb0640) 2016; 13
Yoon (10.1016/j.jconrel.2018.08.042_bb0240) 2013; 13
Mo (10.1016/j.jconrel.2018.08.042_bb0690) 2014; 5
Wheeler (10.1016/j.jconrel.2018.08.042_bb0040) 2014; 16
Yu (10.1016/j.jconrel.2018.08.042_bb0590) 2017; 73
Saravanakumar (10.1016/j.jconrel.2018.08.042_bb0720) 2017; 4
Gupta (10.1016/j.jconrel.2018.08.042_bb0820) 2009; 11
Yan (10.1016/j.jconrel.2018.08.042_bb0255) 2014; 3
Matsumoto (10.1016/j.jconrel.2018.08.042_bb0705) 2012; 51
Sensu (10.1016/j.jconrel.2018.08.042_bb0340) 2006
Lee (10.1016/j.jconrel.2018.08.042_bb0615) 2017; 105
Gittard (10.1016/j.jconrel.2018.08.042_bb0315) 2009; 3
Matriano (10.1016/j.jconrel.2018.08.042_bb0750) 2002; 19
Wang (10.1016/j.jconrel.2018.08.042_bb0465) 2009; 2009
Zhang (10.1016/j.jconrel.2018.08.042_bb0495) 2018; 20
Griss (10.1016/j.jconrel.2018.08.042_bb0445) 2003; 12
Hou (10.1016/j.jconrel.2018.08.042_bb0735) 2017; 43
Yan (10.1016/j.jconrel.2018.08.042_bb0410) 2012; Vol. 18
Rzhevskiy (10.1016/j.jconrel.2018.08.042_bb0195) 2018; 270
Lu (10.1016/j.jconrel.2018.08.042_bb0375) 2004; 19
Mangelsdorf (10.1016/j.jconrel.2018.08.042_bb0165) 2006; 19
Zhou (10.1016/j.jconrel.2018.08.042_bb0190) 2010; 392
Wang (10.1016/j.jconrel.2018.08.042_bb0500) 2014; 23
Omatsu (10.1016/j.jconrel.2018.08.042_bb0230) 2010; 18
Mansoor (10.1016/j.jconrel.2018.08.042_bb0400) 2013; 23
You (10.1016/j.jconrel.2018.08.042_bb0535) 2011; 31
Brazzle (10.1016/j.jconrel.2018.08.042_bb0430) 2000; 2
Mansoor (10.1016/j.jconrel.2018.08.042_bb0480) 2012; 21
Deng (10.1016/j.jconrel.2018.08.042_bb0250) 2016; 6
Bogdanov (10.1016/j.jconrel.2018.08.042_bb0295) 2000; 53
Zhang (10.1016/j.jconrel.2018.08.042_bb0745) 2012; 29
McCarley (10.1016/j.jconrel.2018.08.042_bb0150) 2001; 90
Lau (10.1016/j.jconrel.2018.08.042_bb0580) 2016; 265
Richter-Johnson (10.1016/j.jconrel.2018.08.042_bb0815) 2018; 18
Ito (10.1016/j.jconrel.2018.08.042_bb0540) 2010; 21
Chandrasekaran (10.1016/j.jconrel.2018.08.042_bb0425) 2003; 12
Donnelly (10.1016/j.jconrel.2018.08.042_bb0810) 2018; 23
van der Maaden (10.1016/j.jconrel.2018.08.042_bb0290) 2015; 5
Brandts (10.1016/j.jconrel.2018.08.042_bb0710) 1967; 89
Tsuchiya (10.1016/j.jconrel.2018.08.042_bb0225) 2010; 34
Ita (10.1016/j.jconrel.2018.08.042_bb0320) 2018; 44
Park (10.1016/j.jconrel.2018.08.042_bb0305) 2007; 54
Yuen (10.1016/j.jconrel.2018.08.042_bb0505) 2015; 20
Mo (10.1016/j.jconrel.2018.08.042_bb0020) 2014; 43
Mukerjee (10.1016/j.jconrel.2018.08.042_bb0455) 2004; 114
Guo (10.1016/j.jconrel.2018.08.042_bb0030) 2017; 14
Shikida (10.1016/j.jconrel.2018.08.042_bb0415) 2006; 16
Davis (10.1016/j.jconrel.2018.08.042_bb0390) 2005; 52
Wallqvist (10.1016/j.jconrel.2018.08.042_bb0715) 1998; 120
Hao (10.1016/j.jconrel.2018.08.042_bb0360) 2017; 13
Rouphael (10.1016/j.jconrel.2018.08.042_bb0805) 2017; 390
Stoeber (10.1016/j.jconrel.2018.08.042_bb0450) 2005; 14
Jurcicek (10.1016/j.jconrel.2018.08.042_bb0460) 2013; 8
Jin (10.1016/j.jconrel.2018.08.042_bb0330) 2009; 11
10.1016/j.jconrel.2018.08.042_bb0440
Shikida (10.1016/j.jconrel.2018.08.042_bb0265) 2004; 14
Krauland (10.1016/j.jconrel.2018.08.042_bb0015) 2006; 307
Ye (10.1016/j.jconrel.2018.08.042_bb0520) 2018; 127
Eltayib (10.1016/j.jconrel.2018.08.042_bb0655) 2016; 102
Donnelly (10.1016/j.jconrel.2018.08.042_bb0545) 2009; 35
Panda (10.1016/j.jconrel.2018.08.042_bb0670) 2015; 48
Henry (10.1016/j.jconrel.2018.08.042_bb0120) 1998; 87
Li (10.1016/j.jconrel.2018.08.042_bb0160) 2017; 27
Yu (10.1016/j.jconrel.2018.08.042_bb0200) 2015; 112
Danso (10.1016/j.jconrel.2018.08.042_bb0105) 2015; 24
Lee (10.1016/j.jconrel.2018.08.042_bb0530) 2008; 29
Yu (10.1016/j.jconrel.2018.08.042_bb0685) 2017; 17
O'Mahony (10.1016/j.jconrel.2018.08.042_bb0350) 2012; 186
Hu (10.1016/j.jconrel.2018.08.042_bb0205) 2017; 11
10.1016/j.jconrel.2018.08.042_bb0310
Khanna (10.1016/j.jconrel.2018.08.042_bb0435) 2010; 20
Norman (10.1016/j.jconrel.2018.08.042_bb0405) 2013; 15
Kim (10.1016/j.jconrel.2018.08.042_bb0420) 2007; Vol. 13
Donnelly (10.1016/j.jconrel.2018.08.042_bb0145) 2010; 17
Park (10.1016/j.jconrel.2018.08.042_bb0335) 2005; 104
Sullivan (10.1016/j.jconrel.2018.08.042_bb0560) 2010; 16
Yung (10.1016/j.jconrel.2018.08.042_bb0490) 2012; 22
Montheard (10.1016/j.jconrel.2018.08.042_bb0645) 1992; C32
McAllister (10.1016/j.jconrel.2018.08.042_bb0475) 2003; 100
Li (10.1016/j.jconrel.2018.08.042_bb0175) 2017; 7
Bhatnagar (10.1016/j.jconrel.2018.08.042_bb0785) 2017; 260
References_xml – volume: 27
  year: 2017
  ident: bb0160
  article-title: A novel ultrafine needle (UN) for innocuous and efficient subcutaneous insulin delivery
  publication-title: Adv. Funct. Mater.
– volume: 161
  start-page: 933
  year: 2012
  end-page: 941
  ident: bb0180
  article-title: The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
  publication-title: J. Control. Release
– volume: 30
  start-page: 1099
  year: 2013
  end-page: 1109
  ident: bb0110
  article-title: Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum
  publication-title: Pharm. Res.
– volume: 7
  start-page: 90
  year: 2015
  end-page: 105
  ident: bb0130
  article-title: Transdermal delivery of drugs with microneedles-potential and challenges
  publication-title: Pharmaceutics
– volume: 390
  start-page: 649
  year: 2017
  end-page: 658
  ident: bb0805
  article-title: The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial
  publication-title: Lancet
– volume: 65
  start-page: 152
  year: 2013
  end-page: 168
  ident: bb0115
  article-title: Modeling the human skin barrier - Towards a better understanding of dermal absorption
  publication-title: Adv. Drug Deliv. Rev.
– volume: 270
  start-page: 184
  year: 2018
  end-page: 202
  ident: bb0195
  article-title: Microneedles as the technique of drug delivery enhancement in diverse organs and tissues
  publication-title: J. Control. Release
– volume: 260
  start-page: 164
  year: 2017
  end-page: 182
  ident: bb0785
  article-title: Microneedles in the clinic
  publication-title: J. Control. Release
– volume: 8
  start-page: 2483
  year: 2012
  end-page: 2488
  ident: bb0325
  article-title: Curved biodegradable microneedles for vascular drug delivery
  publication-title: Small
– volume: 20
  year: 2010
  ident: bb0470
  article-title: A high aspect ratio SU-8 fabrication technique for hollow microneedles for transdermal drug delivery and blood extraction
  publication-title: J. Micromech. Microeng.
– volume: 24
  start-page: 585
  year: 2008
  end-page: 594
  ident: bb0515
  article-title: Effect of microneedle design on pain in human volunteers
  publication-title: Clin. J. Pain
– volume: 392
  start-page: 127
  year: 2010
  end-page: 133
  ident: bb0190
  article-title: Transdermal delivery of insulin using microneedle rollers in vivo
  publication-title: Int. J. Pharm.
– volume: 21
  start-page: 835
  year: 2010
  end-page: 841
  ident: bb0540
  article-title: Self-dissolving micropile array tips for percutaneous administration of insulin
  publication-title: Journal of Materials Science-Materials In Medicine
– volume: 104
  start-page: 1
  year: 2016
  end-page: 32
  ident: bb0740
  article-title: Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
  publication-title: Materials Science & Engineering R-Reports
– volume: 414
  start-page: 799
  year: 2001
  ident: bb0010
  article-title: Insulin signalling and the regulation of glucose and lipid metabolism
  publication-title: Nature
– volume: 16
  start-page: 558
  year: 2014
  end-page: 562
  ident: bb0040
  article-title: Insulin pump-associated adverse events in children and adolescents-A prospective study
  publication-title: Diabetes Technol. Ther.
– volume: 19
  start-page: 406
  year: 2004
  end-page: 407
  ident: bb0375
  article-title: Study for the asepsis storage period of insulin in jection after seal removing
  publication-title: Journal of Nurses Training
– volume: 45
  start-page: 203
  year: 2018
  end-page: 212
  ident: bb0060
  article-title: Modulation of transdermal drug delivery with coated microneedles
  publication-title: Journal of Drug Delivery Science and Technology
– volume: 75
  start-page: 10
  year: 2015
  end-page: 24
  ident: bb0125
  article-title: In vitro skin models as a tool in optimization of drug formulation
  publication-title: Eur. J. Pharm. Sci.
– volume: 14
  start-page: 101
  year: 2001
  end-page: 114
  ident: bb0140
  article-title: Novel mechanisms and devices to enable successful transdermal drug delivery
  publication-title: Eur. J. Pharm. Sci.
– volume: 21
  start-page: 44
  year: 2012
  end-page: 52
  ident: bb0480
  article-title: Hollow out-of-plane polymer microneedles made by solvent casting for transdermal drug delivery
  publication-title: J. Microelectromech. Syst.
– volume: 307
  start-page: 270
  year: 2006
  end-page: 277
  ident: bb0015
  article-title: Thiolated chitosan microparticles: A vehicle for nasal peptide drug delivery
  publication-title: Int. J. Pharm.
– volume: 34
  year: 2016
  ident: bb0220
  article-title: Fabrication and characterization of a tungsten microneedle array based on deep reactive ion etching technology
  publication-title: J. Vac. Sci. Technol. B
– year: 23, Aug, 2018
  ident: bb0760
– volume: 17
  start-page: 187
  year: 2010
  end-page: 207
  ident: bb0145
  article-title: Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety
  publication-title: Drug Delivery
– volume: 16
  start-page: 2230
  year: 2006
  end-page: 2239
  ident: bb0415
  article-title: Fabrication of a hollow needle structure by dicing, wet etching and metal deposition
  publication-title: J. Micromech. Microeng.
– volume: 93
  start-page: 1116
  year: 2017
  end-page: 1127
  ident: bb0525
  article-title: Dissolving microneedles for transdermal drug delivery: Advances and challenges
  publication-title: Biomed Pharmacother
– volume: 5
  start-page: 332
  year: 2015
  end-page: 345
  ident: bb0825
  article-title: Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear
  publication-title: Drug Delivery and Translational Research
– volume: 7
  start-page: 15408
  year: 2017
  end-page: 15415
  ident: bb0175
  article-title: A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
  publication-title: RSC Adv.
– volume: 12
  start-page: 296
  year: 2003
  end-page: 301
  ident: bb0445
  article-title: Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer
  publication-title: J. Microelectromech. Syst.
– volume: 56
  start-page: 581
  year: 2004
  end-page: 587
  ident: bb0055
  article-title: Microneedles for transdermal drug delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 5
  year: 2014
  ident: bb0690
  article-title: ATP-triggered anticancer drug delivery
  publication-title: Nat. Commun.
– reference: , 23, Aug, 2018.
– volume: 35
  start-page: 199
  year: 1999
  end-page: 234
  ident: bb0050
  article-title: Intranasal insulin delivery and therapy
  publication-title: Adv. Drug Deliv. Rev.
– volume: 159
  start-page: 52
  year: 2012
  end-page: 59
  ident: bb0565
  article-title: Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
  publication-title: J. Control. Release
– volume: 162
  start-page: 130
  year: 2010
  end-page: 136
  ident: bb0260
  article-title: A wafer-scale etching technique for high aspect ratio implantable MEMS structures
  publication-title: Sensors and Actuators a-Physical
– volume: 15
  start-page: 203
  year: 2013
  end-page: 210
  ident: bb0405
  article-title: Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition
  publication-title: Biomed. Microdevices
– volume: C32
  start-page: 1
  year: 1992
  end-page: 34
  ident: bb0645
  article-title: 2-Hydroxyethyl methacrylate (HEMA)-chemical-properties and applications in biomedical fields
  publication-title: J. Macromol. Sci.-Rev. Macromol. Chem. Phys.
– volume: 6
  year: 2016
  ident: bb0250
  article-title: Transdermal delivery of siRNA through microneedle array
  publication-title: Sci. Rep.
– volume: 12
  start-page: 281
  year: 2003
  end-page: 288
  ident: bb0425
  article-title: Surface micromachined metallic microneedles
  publication-title: J. Microelectromech. Syst.
– volume: 18
  start-page: 359
  year: 2018
  end-page: 369
  ident: bb0815
  article-title: Therapeutic applications and pharmacoeconomics of microneedle technology
  publication-title: Expert Review of Pharmacoeconomics & Outcomes Research
– volume: 33
  start-page: 2472
  year: 2000
  end-page: 2479
  ident: bb0650
  article-title: Structure and morphology of freeze/thawed PVA hydrogels
  publication-title: Macromolecules
– volume: 20
  year: 2010
  ident: bb0435
  article-title: Sharpening of hollow silicon microneedles to reduce skin penetration force
  publication-title: J. Micromech. Microeng.
– volume: 8
  start-page: 453
  year: 2014
  end-page: 457
  ident: bb0135
  article-title: Intradermal insulin delivery: a promising future for diabetes management
  publication-title: Journal of Diabetes Science and Technology
– volume: Vol. 13
  start-page: 231
  year: 2007
  end-page: 235
  ident: bb0420
  article-title: High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector, Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems
– volume: 48
  start-page: 521
  year: 2015
  end-page: 532
  ident: bb0670
  article-title: Development of novel electrospun nanofibrous scaffold from P. ricini and A. mylitta silk fibroin blend with improved surface and biological properties
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: 13
  start-page: 16672
  year: 2013
  end-page: 16681
  ident: bb0240
  article-title: Fabrication of a microneedle/CNT hierarchical micro/nano surface electrochemical sensor and its in-vitro glucose sensing characterization
  publication-title: Sensors
– volume: 16
  year: 2010
  ident: bb0560
  article-title: Dissolving polymer microneedle patches for influenza vaccination
  publication-title: Nat. Med.
– volume: 104
  start-page: 51
  year: 2005
  end-page: 66
  ident: bb0335
  article-title: Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
  publication-title: J. Control. Release
– volume: 35 (
  start-page: 6676
  year: 2017
  end-page: 6684
  ident: bb0235
  article-title: Safety, acceptability and tolerability of uncoated and excipient-coated high density silicon micro-projection array patches in human subjects
  publication-title: Vaccine
– volume: 117
  start-page: 182
  year: 2017
  end-page: 194
  ident: bb0630
  article-title: Poly (methyl vinyl ether-co-maleic acid)-pectin based hydrogel-forming systems: Gel, film, and microneedles
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 19
  start-page: 159
  year: 2006
  end-page: 167
  ident: bb0165
  article-title: Ethnic variation in vellus hair follicle size and distribution
  publication-title: Skin Pharmacol. Physiol.
– volume: 80
  start-page: 187
  year: 2017
  end-page: 196
  ident: bb0595
  article-title: Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: 20
  year: 2015
  ident: bb0505
  article-title: Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements: a skin-mimicking phantom study
  publication-title: J. Biomed. Opt.
– volume: 33
  start-page: 1055
  year: 2016
  end-page: 1073
  ident: bb0045
  article-title: Microneedles: A new frontier in nanomedicine delivery
  publication-title: Pharm. Res.
– volume: 21
  start-page: 947
  year: 2004
  end-page: 952
  ident: bb0070
  article-title: Transdermal delivery of insulin using microneedles in vivo
  publication-title: Pharm. Res.
– volume: 24
  start-page: 106
  year: 2015
  end-page: 116
  ident: bb0605
  article-title: Poly-gamma-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin
  publication-title: Acta Biomater.
– volume: 22
  start-page: 4879
  year: 2012
  end-page: 4890
  ident: bb0385
  article-title: Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery
  publication-title: Adv. Funct. Mater.
– volume: 11
  start-page: 613
  year: 2017
  end-page: 620
  ident: bb0205
  article-title: H
  publication-title: ACS Nano
– volume: 5
  start-page: 397
  year: 2015
  end-page: 406
  ident: bb0290
  article-title: Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
  publication-title: Drug Delivery and Translational Research
– volume: 20
  start-page: 933
  year: 2008
  ident: bb0550
  article-title: Minimally invasive protein delivery with rapidly dissolving polymer microneedles
  publication-title: Adv. Mater.
– volume: 14
  start-page: 255
  year: 2006
  end-page: 261
  ident: bb0555
  article-title: Self-dissolving microneedles for the percutaneous absorption of EPO in mice
  publication-title: J. Drug Target.
– volume: 28
  start-page: 5506
  year: 2017
  end-page: 5510
  ident: bb0830
  article-title: Effect of minimally invasive insulin therapy on primary and secondary outcomes in gestational diabetic women
  publication-title: Biomedical Research-India
– volume: 265
  start-page: 113
  year: 2016
  end-page: 119
  ident: bb0580
  article-title: Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery
  publication-title: Journal of controlled release : official journal of the Controlled Release Society
– volume: 14
  start-page: 891
  year: 2012
  end-page: 899
  ident: bb0610
  article-title: Transdermal insulin application system with dissolving microneedles
  publication-title: Diabetes Technol. Ther.
– volume: 114
  start-page: 267
  year: 2004
  end-page: 275
  ident: bb0455
  article-title: Microneedle array for transdermal biological fluid extraction and in situ analysis
  publication-title: Sensors and Actuators a-Physical
– volume: 11
  start-page: 329
  year: 2009
  end-page: 337
  ident: bb0820
  article-title: Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles
  publication-title: Diabetes Technol. Ther.
– volume: 28
  start-page: 3115
  year: 2016
  end-page: 3121
  ident: bb0675
  article-title: Microneedles integrated with pancreatic cells and synthetic glucose-signal amplifiers for smart insulin delivery
  publication-title: Adv. Mater.
– volume: 21
  start-page: 1084
  year: 2012
  end-page: 1089
  ident: bb0280
  article-title: A flexible microneedle electrode array with solid silicon needles
  publication-title: J. Microelectromech. Syst.
– volume: 8
  start-page: 78
  year: 2013
  end-page: 81
  ident: bb0460
  article-title: Design and fabrication of hollow out-of-plane silicon microneedles
  publication-title: Micro & Nano Letters
– volume: 106
  start-page: 48
  year: 2017
  end-page: 56
  ident: bb0660
  article-title: Swellable silk fibroin microneedles for transdermal drug delivery
  publication-title: Int. J. Biol. Macromol.
– volume: 300
  start-page: 586
  year: 2015
  end-page: 595
  ident: bb0635
  article-title: Microwave-assisted preparation of hydrogel-forming microneedle arrays for transdermal drug delivery applications
  publication-title: Macromol. Mater. Eng.
– volume: 52
  start-page: 2790
  year: 2003
  end-page: 2794
  ident: bb0695
  article-title: Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor
  publication-title: Diabetes
– volume: 9
  start-page: 1292
  year: 2015
  end-page: 1298
  ident: bb0035
  article-title: Using insulin infusion sets in CSII for longer than the recommended usage time leads to a high risk for adverse events: Results from a prospective randomized crossover study
  publication-title: Journal of Diabetes Science and Technology
– volume: 436
  start-page: 387
  year: 2012
  end-page: 393
  ident: bb0585
  article-title: Two-layered dissolving microneedles formulated with intermediate-acting insulin
  publication-title: Int. J. Pharm.
– volume: 22
  start-page: 483
  year: 2010
  ident: bb0300
  article-title: Drawing lithography: Three-dimensional fabrication of an ultrahigh-aspect-ratio microneedle
  publication-title: Adv. Mater.
– volume: 14
  start-page: 1462
  year: 2004
  end-page: 1467
  ident: bb0265
  article-title: Non-photolithographic pattern transfer for fabricating pen-shaped microneedle structures
  publication-title: J. Micromech. Microeng.
– volume: 4
  year: 2017
  ident: bb0720
  article-title: Reactive-oxygen-species-responsive drug delivery systems: Promises and challenges
  publication-title: Advanced Science
– volume: 13
  start-page: 451
  year: 2011
  end-page: 456
  ident: bb0080
  article-title: Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects
  publication-title: Diabetes Technol. Ther.
– volume: 16
  start-page: 1598
  year: 2015
  end-page: 1607
  ident: bb0725
  article-title: Near-infrared light-responsive composite microneedles for on-demand transdermal drug delivery
  publication-title: Biomacromolecules
– volume: 13
  start-page: 443
  year: 2011
  end-page: 450
  ident: bb0835
  article-title: Microneedle-based intradermal versus subcutaneous administration of regular human insulin or insulin lispro: Pharmacokinetics and postprandial glycemic excursions in patients with type 1 diabetes
  publication-title: Diabetes Technol. Ther.
– volume: 25
  start-page: 4633
  year: 2015
  end-page: 4641
  ident: bb0625
  article-title: Phase-transition microneedle patches for efficient and accurate transdermal delivery of insulin
  publication-title: Adv. Funct. Mater.
– volume: 26
  start-page: 31
  year: 2011
  end-page: 35
  ident: bb0345
  article-title: UV cationic photo-initiator and the development trend
  publication-title: China Coatings
– volume: 14
  start-page: 727
  year: 2017
  end-page: 734
  ident: bb0030
  article-title: Challenges and recent advances in the subcutaneous delivery of insulin
  publication-title: Expert Opinion on Drug Delivery
– volume: 44
  start-page: 1566
  year: 2016
  end-page: 1575
  ident: bb0245
  article-title: Microneedle electrode array for electrical impedance myography to characterize neurogenic myopathy
  publication-title: Ann. Biomed. Eng.
– volume: 7
  start-page: 5067
  year: 2017
  end-page: 5075
  ident: bb0600
  article-title: Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery
  publication-title: RSC Adv.
– volume: 19
  start-page: 63
  year: 2002
  end-page: 70
  ident: bb0750
  article-title: Macroflux (R) microprojection array patch technology: A new and efficient approach for intracutaneous immunization
  publication-title: Pharm. Res.
– volume: 7
  start-page: 185
  year: 2005
  end-page: 188
  ident: bb0090
  article-title: Sugar micro needles as transdermic drug delivery system
  publication-title: Biomed. Microdevices
– reference: J. Ji, F.E.H. Tay, J. Miao, Microfabricated hollow microneedle array using ICP etcher, in: International Mems Conference 2006, 2006, pp. 1132–1136.
– volume: 14
  start-page: 459
  year: 2013
  end-page: 465
  ident: bb0395
  article-title: Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes
  publication-title: Pediatr. Diabetes
– volume: 18
  start-page: 17967
  year: 2010
  end-page: 17973
  ident: bb0230
  article-title: Metal microneedle fabrication using twisted light with spin
  publication-title: Opt. Express
– volume: 127
  start-page: 106
  year: 2018
  end-page: 118
  ident: bb0520
  article-title: Polymeric microneedles for transdermal protein delivery
  publication-title: Adv. Drug Deliv. Rev.
– volume: 73
  start-page: 425
  year: 2017
  end-page: 428
  ident: bb0590
  article-title: Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: 265
  start-page: 2
  year: 2017
  end-page: 13
  ident: bb0215
  article-title: Formulation of hydrophobic peptides for skin delivery via coated microneedles
  publication-title: J. Control. Release
– volume: 11
  start-page: 1195
  year: 2009
  end-page: 1203
  ident: bb0330
  article-title: Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery
  publication-title: Biomed. Microdevices
– volume: 17
  start-page: 733
  year: 2017
  end-page: 739
  ident: bb0685
  article-title: Hypoxia and H
  publication-title: Nano Lett.
– volume: 8
  start-page: 221
  year: 2012
  end-page: 227
  ident: bb0155
  article-title: Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management
  publication-title: Nanomedicine-Nanotechnology Biology and Medicine
– volume: 3
  start-page: 555
  year: 2014
  end-page: 564
  ident: bb0255
  article-title: Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin
  publication-title: Advanced Healthcare Materials
– volume: 127
  start-page: 119
  year: 2018
  end-page: 137
  ident: bb0780
  article-title: Insulin delivery systems combined with microneedle technology
  publication-title: Adv. Drug Deliv. Rev.
– volume: 53
  start-page: 493
  year: 2000
  end-page: 496
  ident: bb0295
  article-title: Use of SU-8 photoresist for very high aspect ratio x-ray lithography
  publication-title: Microelectron. Eng.
– volume: 43
  start-page: 321
  year: 2017
  end-page: 339
  ident: bb0735
  article-title: Microneedling: A comprehensive review
  publication-title: Dermatol. Surg.
– volume: 43
  start-page: 3595
  year: 2014
  end-page: 3629
  ident: bb0020
  article-title: Emerging micro-and nanotechnology based synthetic approaches for insulin delivery
  publication-title: Chem. Soc. Rev.
– volume: 87
  start-page: 922
  year: 1998
  end-page: 925
  ident: bb0120
  article-title: Microfabricated microneedles: A novel approach to transdermal drug delivery
  publication-title: J. Pharm. Sci.
– volume: 100
  start-page: 13755
  year: 2003
  end-page: 13760
  ident: bb0475
  article-title: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 23
  start-page: 1026
  year: 2018
  end-page: 1033
  ident: bb0810
  article-title: Microarray patches: potentially useful delivery systems for long-acting nanosuspensions
  publication-title: Drug Discov. Today
– volume: 18
  start-page: 525
  year: 2016
  end-page: 531
  ident: bb0790
  article-title: Improved insulin pharmacokinetics using a novel microneedle device for intradermal delivery in patients with type 2 diabetes
  publication-title: Diabetes Technol. Ther.
– volume: 89
  start-page: 4826
  year: 1967
  ident: bb0710
  article-title: Thermodynamics of protein denaturation .3. Denaturation of ribonuclease in water and in aqueous urea and aqueous ethanol mixtures
  publication-title: J. Am. Chem. Soc.
– volume: 9
  start-page: 8952
  year: 2013
  end-page: 8961
  ident: bb0185
  article-title: Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
  publication-title: Acta Biomater.
– volume: 34
  start-page: 461
  year: 2010
  end-page: 466
  ident: bb0225
  article-title: Design and development of a biocompatible painless microneedle by the ion sputtering deposition method
  publication-title: Precision Engineering-Journal of the International Societies for Precision Engineering and Nanotechnology
– year: 2010
  ident: bb0765
  article-title: Microneedle array, patch, and applicator for transdermal drug delivery, in
– volume: 120
  start-page: 427
  year: 1998
  end-page: 428
  ident: bb0715
  article-title: Hydrophobic interactions in aqueous urea solutions with implications for the mechanism of protein denaturation
  publication-title: J. Am. Chem. Soc.
– volume: 96
  start-page: 1167
  year: 2008
  end-page: 1183
  ident: bb0275
  article-title: Noninvasive neural prostheses using mobile and wireless EEG
  publication-title: Proceedings of the Leee
– volume: 23
  start-page: 991
  year: 2014
  end-page: 998
  ident: bb0500
  article-title: Hypodermic-needle-like hollow polymer microneedle array: Fabrication and characterization
  publication-title: J. Microelectromech. Syst.
– start-page: U1425
  year: 2006
  end-page: U1436
  ident: bb0340
  article-title: Study of cross-linking reactions in negative-type thick-film resists
  publication-title: Advances in Resist Technology and Processing Xxiii, Pts 1 And 2
– volume: 54
  start-page: 903
  year: 2007
  end-page: 913
  ident: bb0305
  article-title: Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery
  publication-title: Leee Transactions on Biomedical Engineering
– volume: 16
  start-page: 473
  year: 2006
  end-page: 479
  ident: bb0485
  article-title: Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol
  publication-title: J. Micromech. Microeng.
– volume: 14
  start-page: 472
  year: 2005
  end-page: 479
  ident: bb0450
  article-title: Arrays of hollow out-of-plane microneedles for drug delivery
  publication-title: J. Microelectromech. Syst.
– volume: 52
  start-page: 909
  year: 2005
  end-page: 915
  ident: bb0390
  article-title: Hollow metal microneedles for insulin delivery to diabetic rats
  publication-title: IEEE Trans. Biomed. Eng.
– volume: 139
  start-page: 63
  year: 2009
  end-page: 72
  ident: bb0380
  article-title: Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin
  publication-title: J. Control. Release
– volume: 251
  start-page: 11
  year: 2017
  end-page: 23
  ident: bb0510
  article-title: Microneedle, bio-microneedle and bio-inspired microneedle: A review
  publication-title: J. Control. Release
– volume: 105
  start-page: 84
  year: 2017
  end-page: 93
  ident: bb0615
  article-title: Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
  publication-title: J. Biomed. Mater. Res. A
– volume: 110
  start-page: 30
  year: 2018
  end-page: 38
  ident: bb0065
  article-title: Microneedles: A versatile strategy for transdermal delivery of biological molecules
  publication-title: Int. J. Biol. Macromol.
– volume: 24
  start-page: 48
  year: 2015
  end-page: 54
  ident: bb0105
  article-title: An ex vivo human skin model for studying skin barrier repair
  publication-title: Exp. Dermatol.
– volume: 8
  year: 2017
  ident: bb0210
  article-title: Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
  publication-title: Nat. Commun.
– volume: 29
  start-page: 2113
  year: 2008
  end-page: 2124
  ident: bb0530
  article-title: Dissolving microneedles for transdermal drug delivery
  publication-title: Biomaterials
– volume: 20
  year: 2010
  ident: bb0285
  article-title: Design of experiment characterization of microneedle fabrication processes based on dry silicon etching
  publication-title: J. Micromech. Microeng.
– volume: 20
  year: 2018
  ident: bb0495
  article-title: Finite element analysis of hollow out-of-plane HfO
  publication-title: Biomed. Microdevices
– volume: 5
  start-page: 8200
  year: 2017
  end-page: 8208
  ident: bb0680
  article-title: H
  publication-title: J. Mater. Chem. B
– volume: 29
  start-page: 170
  year: 2012
  end-page: 177
  ident: bb0745
  article-title: Development of lidocaine-coated microneedle product for rapid, safe, and prolonged local analgesic action
  publication-title: Pharm. Res.
– volume: 5
  start-page: 51934
  year: 2015
  end-page: 51946
  ident: bb0025
  article-title: Biodegradable and conductive chitosan-graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics
  publication-title: RSC Adv.
– volume: 6
  start-page: 743
  year: 2012
  end-page: 754
  ident: bb0795
  article-title: Pharmacokinetics and postprandial glycemic excursions following insulin lispro delivered by intradermal microneedle or subcutaneous infusion
  publication-title: Journal of Diabetes Science and Technology
– volume: 5
  start-page: 9507
  year: 2017
  end-page: 9513
  ident: bb0730
  article-title: Near-infrared light triggered and separable microneedles for transdermal delivery of metformin in diabetic rats
  publication-title: J. Mater. Chem. B
– volume: 437
  start-page: 51
  year: 2012
  end-page: 56
  ident: bb0370
  article-title: Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery
  publication-title: Int. J. Pharm.
– volume: 102
  start-page: 123
  year: 2016
  end-page: 131
  ident: bb0655
  article-title: Hydrogel-forming microneedle arrays: Potential for use in minimally-invasive lithium monitoring
  publication-title: Eur. J. Pharm. Biopharm.
– volume: 22
  year: 2012
  ident: bb0490
  article-title: Sharp tipped plastic hollow microneedle array by microinjection moulding
  publication-title: J. Micromech. Microeng.
– volume: 14
  start-page: 375
  year: 2007
  end-page: 381
  ident: bb0755
  article-title: Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines
  publication-title: Clin. Vaccine Immunol.
– volume: 186
  start-page: 130
  year: 2012
  end-page: 136
  ident: bb0350
  article-title: Microneedle-based electrodes with integrated through-silicon via for biopotential recording
  publication-title: Sensors and Actuators a-Physical
– volume: 51
  start-page: 2124
  year: 2012
  end-page: 2128
  ident: bb0705
  article-title: A synthetic approach toward a self-regulated insulin delivery system
  publication-title: Angewandte Chemie-International Edition
– volume: 2009
  start-page: 7026
  year: 2009
  end-page: 7029
  ident: bb0465
  article-title: Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique
  publication-title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
– volume: 13
  start-page: 1581
  year: 2017
  end-page: 1597
  ident: bb0360
  article-title: Microneedles-based transdermal drug delivery systems: A review
  publication-title: J. Biomed. Nanotechnol.
– volume: 3
  start-page: 304
  year: 2009
  end-page: 311
  ident: bb0315
  article-title: Fabrication of polymer microneedles using a two-photon polymerization and micromolding process
  publication-title: Journal of Diabetes Science and Technology
– volume: 110
  start-page: 11377
  year: 2006
  end-page: 11382
  ident: bb0270
  article-title: Reactive species generated during wet chemical etching of silicon in HF/HNO
  publication-title: J. Phys. Chem. B
– volume: 16
  year: 2016
  ident: bb0355
  article-title: An improved manufacturing approach for discrete silicon microneedle arrays with tunable height-pitch ratio
  publication-title: Sensors
– volume: 90
  start-page: 1699
  year: 2001
  end-page: 1719
  ident: bb0150
  article-title: Pharmacokinetic models of dermal absorption
  publication-title: J. Pharm. Sci.
– volume: 71
  start-page: 725
  year: 2017
  end-page: 734
  ident: bb0075
  article-title: Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: Vol. 18
  start-page: 37
  year: 2012
  end-page: 42
  ident: bb0410
  article-title: Hollow metallic microneedles fabricated by combining bulk silicon micromachining and UV-LIGA technology, Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems
– volume: 37
  start-page: 1387
  year: 2011
  end-page: 1393
  ident: bb0570
  article-title: Two-layered dissolving microneedles for percutaneous delivery of sumatriptan in rats
  publication-title: Drug Dev. Ind. Pharm.
– volume: 6
  start-page: 191
  year: 2014
  end-page: 199
  ident: bb0620
  article-title: Hydrogel microneedle arrays for transdermal drug delivery
  publication-title: Nano-Micro Letters
– volume: 54
  start-page: S41
  year: 2002
  end-page: S55
  ident: bb0100
  article-title: Skin structure and mode of action of vesicles
  publication-title: Adv. Drug Deliv. Rev.
– volume: 29
  start-page: 82
  year: 2006
  end-page: 88
  ident: bb0095
  article-title: Feasibility of microneedles for percutaneous absorption of insulin
  publication-title: Eur. J. Pharm. Sci.
– volume: 31
  start-page: 1632
  year: 2011
  end-page: 1636
  ident: bb0535
  article-title: Rapidly dissolving fibroin microneedles for transdermal drug delivery
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: 13
  start-page: 435
  year: 2011
  end-page: 442
  ident: bb0800
  article-title: Intradermal microneedle delivery of insulin lispro achieves faster insulin absorption and insulin action than subcutaneous injection
  publication-title: Diabetes Technol. Ther.
– volume: 2
  start-page: 197
  year: 2000
  end-page: 205
  ident: bb0430
  article-title: Hollow metallic micromachined needle arrays
  publication-title: Biomed. Microdevices
– volume: 85
  start-page: 18
  year: 2018
  end-page: 26
  ident: bb0575
  article-title: Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
– volume: 9
  start-page: 3704
  year: 2013
  end-page: 3713
  ident: bb0665
  article-title: Transdermal delivery devices: Fabrication, mechanics and drug release from silk
  publication-title: Small
– volume: 23
  year: 2013
  ident: bb0400
  article-title: Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures
  publication-title: J. Micromech. Microeng.
– volume: 3
  start-page: 357
  year: 2001
  end-page: 365
  ident: bb0700
  article-title: Comparison of glucose concentration in interstitial fluid, and capillary and venous blood during rapid changes in blood glucose levels
  publication-title: Diabetes Technol. Ther.
– volume: 25
  year: 2015
  ident: bb0365
  article-title: Dense vertical SU-8 microneedles drawn from a heated mold with precisely controlled volume
  publication-title: J. Micromech. Microeng.
– volume: 13
  start-page: 907
  year: 2016
  end-page: 914
  ident: bb0640
  article-title: Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery
  publication-title: Mol. Pharm.
– volume: 103
  start-page: 1478
  year: 2014
  end-page: 1486
  ident: bb0085
  article-title: Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected
  publication-title: J. Pharm. Sci.
– volume: 112
  start-page: 8260
  year: 2015
  end-page: 8265
  ident: bb0200
  article-title: Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 44
  start-page: 314
  year: 2018
  end-page: 322
  ident: bb0320
  article-title: Ceramic microneedles and hollow microneedles for transdermal drug delivery: Two decades of research
  publication-title: Journal of Drug Delivery Science and Technology
– volume: 35
  start-page: 1242
  year: 2009
  end-page: 1254
  ident: bb0545
  article-title: Processing difficulties and instability of carbohydrate microneedle arrays
  publication-title: Drug Dev. Ind. Pharm.
– volume: 86
  start-page: 284
  year: 2014
  end-page: 291
  ident: bb0170
  article-title: Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate
  publication-title: Eur. J. Pharm. Biopharm.
– reference: S.J. Moon, C.Y. Jin, S.S. Lee, A novel method of microneedle array fabrication using inclined deep X-ray exposure, in: International Mems Conference 2006, 2006, pp. 180–186.
– volume: 14
  start-page: 727
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0030
  article-title: Challenges and recent advances in the subcutaneous delivery of insulin
  publication-title: Expert Opinion on Drug Delivery
  doi: 10.1080/17425247.2016.1232247
– volume: 17
  start-page: 733
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0685
  article-title: Hypoxia and H2O2 dual-sensitive vesicles for enhanced glucose-responsive insulin delivery
  publication-title: Nano Lett.
  doi: 10.1021/acs.nanolett.6b03848
– volume: 6
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0250
  article-title: Transdermal delivery of siRNA through microneedle array
  publication-title: Sci. Rep.
– volume: 86
  start-page: 284
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0170
  article-title: Microneedle-assisted delivery of verapamil hydrochloride and amlodipine besylate
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2013.10.007
– volume: 45
  start-page: 203
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0060
  article-title: Modulation of transdermal drug delivery with coated microneedles
  publication-title: Journal of Drug Delivery Science and Technology
  doi: 10.1016/j.jddst.2018.03.021
– volume: 34
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0220
  article-title: Fabrication and characterization of a tungsten microneedle array based on deep reactive ion etching technology
  publication-title: J. Vac. Sci. Technol. B
  doi: 10.1116/1.4960715
– volume: 12
  start-page: 296
  year: 2003
  ident: 10.1016/j.jconrel.2018.08.042_bb0445
  article-title: Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2003.809959
– volume: 73
  start-page: 425
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0590
  article-title: Transdermal delivery of insulin with bioceramic composite microneedles fabricated by gelatin and hydroxyapatite
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2016.12.111
– volume: 90
  start-page: 1699
  year: 2001
  ident: 10.1016/j.jconrel.2018.08.042_bb0150
  article-title: Pharmacokinetic models of dermal absorption
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.1120
– volume: 23
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0400
  article-title: Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/23/8/085011
– volume: 4
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0720
  article-title: Reactive-oxygen-species-responsive drug delivery systems: Promises and challenges
  publication-title: Advanced Science
  doi: 10.1002/advs.201600124
– volume: 21
  start-page: 1084
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0280
  article-title: A flexible microneedle electrode array with solid silicon needles
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2012.2203790
– volume: 18
  start-page: 359
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0815
  article-title: Therapeutic applications and pharmacoeconomics of microneedle technology
  publication-title: Expert Review of Pharmacoeconomics & Outcomes Research
  doi: 10.1080/14737167.2018.1485100
– volume: 7
  start-page: 185
  year: 2005
  ident: 10.1016/j.jconrel.2018.08.042_bb0090
  article-title: Sugar micro needles as transdermic drug delivery system
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-005-3024-7
– volume: 100
  start-page: 13755
  year: 2003
  ident: 10.1016/j.jconrel.2018.08.042_bb0475
  article-title: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.2331316100
– volume: 159
  start-page: 52
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0565
  article-title: Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2012.01.003
– volume: 26
  start-page: 31
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0345
  article-title: UV cationic photo-initiator and the development trend
  publication-title: China Coatings
– volume: 112
  start-page: 8260
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0200
  article-title: Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1505405112
– volume: 16
  start-page: 558
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0040
  article-title: Insulin pump-associated adverse events in children and adolescents-A prospective study
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2013.0388
– volume: 48
  start-page: 521
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0670
  article-title: Development of novel electrospun nanofibrous scaffold from P. ricini and A. mylitta silk fibroin blend with improved surface and biological properties
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2014.12.010
– volume: 87
  start-page: 922
  year: 1998
  ident: 10.1016/j.jconrel.2018.08.042_bb0120
  article-title: Microfabricated microneedles: A novel approach to transdermal drug delivery
  publication-title: J. Pharm. Sci.
  doi: 10.1021/js980042+
– volume: 29
  start-page: 170
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0745
  article-title: Development of lidocaine-coated microneedle product for rapid, safe, and prolonged local analgesic action
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-011-0524-4
– volume: 13
  start-page: 443
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0835
  article-title: Microneedle-based intradermal versus subcutaneous administration of regular human insulin or insulin lispro: Pharmacokinetics and postprandial glycemic excursions in patients with type 1 diabetes
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2010.0183
– volume: 114
  start-page: 267
  year: 2004
  ident: 10.1016/j.jconrel.2018.08.042_bb0455
  article-title: Microneedle array for transdermal biological fluid extraction and in situ analysis
  publication-title: Sensors and Actuators a-Physical
  doi: 10.1016/j.sna.2003.11.008
– volume: 2009
  start-page: 7026
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0465
  article-title: Hollow polymer microneedle array fabricated by photolithography process combined with micromolding technique
– volume: 436
  start-page: 387
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0585
  article-title: Two-layered dissolving microneedles formulated with intermediate-acting insulin
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2012.06.047
– volume: 13
  start-page: 907
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0640
  article-title: Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.5b00807
– volume: 20
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0495
  article-title: Finite element analysis of hollow out-of-plane HfO2 microneedles for transdermal drug delivery applications
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-018-0262-z
– volume: 56
  start-page: 581
  year: 2004
  ident: 10.1016/j.jconrel.2018.08.042_bb0055
  article-title: Microneedles for transdermal drug delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2003.10.023
– volume: 54
  start-page: 903
  year: 2007
  ident: 10.1016/j.jconrel.2018.08.042_bb0305
  article-title: Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery
  publication-title: Leee Transactions on Biomedical Engineering
  doi: 10.1109/TBME.2006.889173
– volume: 20
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0470
  article-title: A high aspect ratio SU-8 fabrication technique for hollow microneedles for transdermal drug delivery and blood extraction
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/20/6/064006
– volume: 5
  start-page: 8200
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0680
  article-title: H2O2-responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02082A
– volume: 52
  start-page: 2790
  year: 2003
  ident: 10.1016/j.jconrel.2018.08.042_bb0695
  article-title: Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor
  publication-title: Diabetes
  doi: 10.2337/diabetes.52.11.2790
– volume: 35
  start-page: 199
  year: 1999
  ident: 10.1016/j.jconrel.2018.08.042_bb0050
  article-title: Intranasal insulin delivery and therapy
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(98)00073-8
– volume: 300
  start-page: 586
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0635
  article-title: Microwave-assisted preparation of hydrogel-forming microneedle arrays for transdermal drug delivery applications
  publication-title: Macromol. Mater. Eng.
  doi: 10.1002/mame.201500016
– volume: 6
  start-page: 743
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0795
  article-title: Pharmacokinetics and postprandial glycemic excursions following insulin lispro delivered by intradermal microneedle or subcutaneous infusion
  publication-title: Journal of Diabetes Science and Technology
  doi: 10.1177/193229681200600403
– volume: 392
  start-page: 127
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0190
  article-title: Transdermal delivery of insulin using microneedle rollers in vivo
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2010.03.041
– volume: 16
  start-page: 2230
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0415
  article-title: Fabrication of a hollow needle structure by dicing, wet etching and metal deposition
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/16/10/041
– volume: 71
  start-page: 725
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0075
  article-title: Fabrication of biodegradable composite microneedles based on calcium sulfate and gelatin for transdermal delivery of insulin
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2016.10.063
– volume: 15
  start-page: 203
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0405
  article-title: Hollow microneedles for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-012-9717-9
– volume: 9
  start-page: 1292
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0035
  article-title: Using insulin infusion sets in CSII for longer than the recommended usage time leads to a high risk for adverse events: Results from a prospective randomized crossover study
  publication-title: Journal of Diabetes Science and Technology
  doi: 10.1177/1932296815604438
– volume: 260
  start-page: 164
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0785
  article-title: Microneedles in the clinic
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.05.029
– volume: 44
  start-page: 1566
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0245
  article-title: Microneedle electrode array for electrical impedance myography to characterize neurogenic myopathy
  publication-title: Ann. Biomed. Eng.
  doi: 10.1007/s10439-015-1466-5
– volume: 5
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0690
  article-title: ATP-triggered anticancer drug delivery
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms4364
– volume: 22
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0490
  article-title: Sharp tipped plastic hollow microneedle array by microinjection moulding
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/22/1/015016
– volume: 28
  start-page: 3115
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0675
  article-title: Microneedles integrated with pancreatic cells and synthetic glucose-signal amplifiers for smart insulin delivery
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201506025
– volume: 11
  start-page: 329
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0820
  article-title: Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2008.0103
– volume: 8
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0210
  article-title: Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01764-1
– volume: 14
  start-page: 255
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0555
  article-title: Self-dissolving microneedles for the percutaneous absorption of EPO in mice
  publication-title: J. Drug Target.
  doi: 10.1080/10611860600785080
– volume: 414
  start-page: 799
  year: 2001
  ident: 10.1016/j.jconrel.2018.08.042_bb0010
  article-title: Insulin signalling and the regulation of glucose and lipid metabolism
  publication-title: Nature
  doi: 10.1038/414799a
– volume: 14
  start-page: 101
  year: 2001
  ident: 10.1016/j.jconrel.2018.08.042_bb0140
  article-title: Novel mechanisms and devices to enable successful transdermal drug delivery
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/S0928-0987(01)00167-1
– volume: 52
  start-page: 909
  year: 2005
  ident: 10.1016/j.jconrel.2018.08.042_bb0390
  article-title: Hollow metal microneedles for insulin delivery to diabetic rats
  publication-title: IEEE Trans. Biomed. Eng.
  doi: 10.1109/TBME.2005.845240
– volume: 21
  start-page: 835
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0540
  article-title: Self-dissolving micropile array tips for percutaneous administration of insulin
  publication-title: Journal of Materials Science-Materials In Medicine
  doi: 10.1007/s10856-009-3923-x
– volume: 7
  start-page: 90
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0130
  article-title: Transdermal delivery of drugs with microneedles-potential and challenges
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics7030090
– volume: 307
  start-page: 270
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0015
  article-title: Thiolated chitosan microparticles: A vehicle for nasal peptide drug delivery
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2005.10.016
– year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0765
– volume: 8
  start-page: 2483
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0325
  article-title: Curved biodegradable microneedles for vascular drug delivery
  publication-title: Small
  doi: 10.1002/smll.201200441
– volume: 13
  start-page: 1581
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0360
  article-title: Microneedles-based transdermal drug delivery systems: A review
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2017.2474
– volume: 8
  start-page: 221
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0155
  article-title: Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management
  publication-title: Nanomedicine-Nanotechnology Biology and Medicine
  doi: 10.1016/j.nano.2011.05.017
– volume: 186
  start-page: 130
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0350
  article-title: Microneedle-based electrodes with integrated through-silicon via for biopotential recording
  publication-title: Sensors and Actuators a-Physical
  doi: 10.1016/j.sna.2012.04.037
– volume: 11
  start-page: 613
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0205
  article-title: H2O2-responsive vesicles integrated with transcutaneous patches for glucose-mediated insulin delivery
  publication-title: ACS Nano
  doi: 10.1021/acsnano.6b06892
– volume: 18
  start-page: 525
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0790
  article-title: Improved insulin pharmacokinetics using a novel microneedle device for intradermal delivery in patients with type 2 diabetes
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2016.0156
– volume: Vol. 13
  start-page: 231
  year: 2007
  ident: 10.1016/j.jconrel.2018.08.042_bb0420
– volume: 22
  start-page: 483
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0300
  article-title: Drawing lithography: Three-dimensional fabrication of an ultrahigh-aspect-ratio microneedle
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200902418
– volume: 12
  start-page: 281
  year: 2003
  ident: 10.1016/j.jconrel.2018.08.042_bb0425
  article-title: Surface micromachined metallic microneedles
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2003.809951
– volume: 20
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0285
  article-title: Design of experiment characterization of microneedle fabrication processes based on dry silicon etching
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/20/2/025024
– volume: 5
  start-page: 9507
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0730
  article-title: Near-infrared light triggered and separable microneedles for transdermal delivery of metformin in diabetic rats
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02236K
– volume: 33
  start-page: 1055
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0045
  article-title: Microneedles: A new frontier in nanomedicine delivery
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-016-1885-5
– volume: 265
  start-page: 113
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0580
  article-title: Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery
  publication-title: Journal of controlled release : official journal of the Controlled Release Society
  doi: 10.1016/j.jconrel.2016.08.031
– ident: 10.1016/j.jconrel.2018.08.042_bb0770
– volume: 103
  start-page: 1478
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0085
  article-title: Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected
  publication-title: J. Pharm. Sci.
  doi: 10.1002/jps.23921
– volume: 110
  start-page: 11377
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0270
  article-title: Reactive species generated during wet chemical etching of silicon in HF/HNO3 mixtures
  publication-title: J. Phys. Chem. B
  doi: 10.1021/jp0608168
– volume: 44
  start-page: 314
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0320
  article-title: Ceramic microneedles and hollow microneedles for transdermal drug delivery: Two decades of research
  publication-title: Journal of Drug Delivery Science and Technology
  doi: 10.1016/j.jddst.2018.01.004
– volume: 89
  start-page: 4826
  year: 1967
  ident: 10.1016/j.jconrel.2018.08.042_bb0710
  article-title: Thermodynamics of protein denaturation .3. Denaturation of ribonuclease in water and in aqueous urea and aqueous ethanol mixtures
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00995a002
– volume: 16
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0355
  article-title: An improved manufacturing approach for discrete silicon microneedle arrays with tunable height-pitch ratio
  publication-title: Sensors
– volume: 19
  start-page: 63
  year: 2002
  ident: 10.1016/j.jconrel.2018.08.042_bb0750
  article-title: Macroflux (R) microprojection array patch technology: A new and efficient approach for intracutaneous immunization
  publication-title: Pharm. Res.
  doi: 10.1023/A:1013607400040
– volume: 8
  start-page: 453
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0135
  article-title: Intradermal insulin delivery: a promising future for diabetes management
  publication-title: Journal of Diabetes Science and Technology
  doi: 10.1177/1932296814530060
– volume: 21
  start-page: 947
  year: 2004
  ident: 10.1016/j.jconrel.2018.08.042_bb0070
  article-title: Transdermal delivery of insulin using microneedles in vivo
  publication-title: Pharm. Res.
  doi: 10.1023/B:PHAM.0000029282.44140.2e
– volume: 270
  start-page: 184
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0195
  article-title: Microneedles as the technique of drug delivery enhancement in diverse organs and tissues
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.11.048
– volume: 93
  start-page: 1116
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0525
  article-title: Dissolving microneedles for transdermal drug delivery: Advances and challenges
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2017.07.019
– volume: 24
  start-page: 585
  year: 2008
  ident: 10.1016/j.jconrel.2018.08.042_bb0515
  article-title: Effect of microneedle design on pain in human volunteers
  publication-title: Clin. J. Pain
  doi: 10.1097/AJP.0b013e31816778f9
– volume: 117
  start-page: 182
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0630
  article-title: Poly (methyl vinyl ether-co-maleic acid)-pectin based hydrogel-forming systems: Gel, film, and microneedles
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2017.04.018
– ident: 10.1016/j.jconrel.2018.08.042_bb0775
– volume: 18
  start-page: 17967
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0230
  article-title: Metal microneedle fabrication using twisted light with spin
  publication-title: Opt. Express
  doi: 10.1364/OE.18.017967
– volume: 85
  start-page: 18
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0575
  article-title: Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2017.12.006
– volume: 25
  start-page: 4633
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0625
  article-title: Phase-transition microneedle patches for efficient and accurate transdermal delivery of insulin
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201500554
– volume: 43
  start-page: 3595
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0020
  article-title: Emerging micro-and nanotechnology based synthetic approaches for insulin delivery
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/c3cs60436e
– volume: 14
  start-page: 891
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0610
  article-title: Transdermal insulin application system with dissolving microneedles
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2012.0096
– volume: 104
  start-page: 51
  year: 2005
  ident: 10.1016/j.jconrel.2018.08.042_bb0335
  article-title: Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2005.02.002
– volume: 251
  start-page: 11
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0510
  article-title: Microneedle, bio-microneedle and bio-inspired microneedle: A review
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.02.011
– volume: 390
  start-page: 649
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0805
  article-title: The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(17)30575-5
– volume: 13
  start-page: 16672
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0240
  article-title: Fabrication of a microneedle/CNT hierarchical micro/nano surface electrochemical sensor and its in-vitro glucose sensing characterization
  publication-title: Sensors
  doi: 10.3390/s131216672
– volume: 3
  start-page: 357
  year: 2001
  ident: 10.1016/j.jconrel.2018.08.042_bb0700
  article-title: Comparison of glucose concentration in interstitial fluid, and capillary and venous blood during rapid changes in blood glucose levels
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/15209150152607132
– volume: 5
  start-page: 332
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0825
  article-title: Intradermal insulin infusion achieves faster insulin action than subcutaneous infusion for 3-day wear
  publication-title: Drug Delivery and Translational Research
  doi: 10.1007/s13346-015-0239-x
– volume: 3
  start-page: 304
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0315
  article-title: Fabrication of polymer microneedles using a two-photon polymerization and micromolding process
  publication-title: Journal of Diabetes Science and Technology
  doi: 10.1177/193229680900300211
– volume: 21
  start-page: 44
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0480
  article-title: Hollow out-of-plane polymer microneedles made by solvent casting for transdermal drug delivery
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2011.2174429
– volume: 28
  start-page: 5506
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0830
  article-title: Effect of minimally invasive insulin therapy on primary and secondary outcomes in gestational diabetic women
  publication-title: Biomedical Research-India
– volume: 29
  start-page: 2113
  year: 2008
  ident: 10.1016/j.jconrel.2018.08.042_bb0530
  article-title: Dissolving microneedles for transdermal drug delivery
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2007.12.048
– volume: 16
  start-page: 1598
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0725
  article-title: Near-infrared light-responsive composite microneedles for on-demand transdermal drug delivery
  publication-title: Biomacromolecules
  doi: 10.1021/acs.biomac.5b00185
– volume: 20
  start-page: 933
  year: 2008
  ident: 10.1016/j.jconrel.2018.08.042_bb0550
  article-title: Minimally invasive protein delivery with rapidly dissolving polymer microneedles
  publication-title: Adv. Mater.
  doi: 10.1002/adma.200701205
– volume: 8
  start-page: 78
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0460
  article-title: Design and fabrication of hollow out-of-plane silicon microneedles
  publication-title: Micro & Nano Letters
  doi: 10.1049/mnl.2012.0903
– volume: 162
  start-page: 130
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0260
  article-title: A wafer-scale etching technique for high aspect ratio implantable MEMS structures
  publication-title: Sensors and Actuators a-Physical
  doi: 10.1016/j.sna.2010.06.011
– volume: 19
  start-page: 159
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0165
  article-title: Ethnic variation in vellus hair follicle size and distribution
  publication-title: Skin Pharmacol. Physiol.
  doi: 10.1159/000093050
– volume: 16
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0560
  article-title: Dissolving polymer microneedle patches for influenza vaccination
  publication-title: Nat. Med.
  doi: 10.1038/nm.2182
– volume: 25
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0365
  article-title: Dense vertical SU-8 microneedles drawn from a heated mold with precisely controlled volume
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/25/2/025013
– volume: 120
  start-page: 427
  year: 1998
  ident: 10.1016/j.jconrel.2018.08.042_bb0715
  article-title: Hydrophobic interactions in aqueous urea solutions with implications for the mechanism of protein denaturation
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja972053v
– volume: 75
  start-page: 10
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0125
  article-title: In vitro skin models as a tool in optimization of drug formulation
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2015.02.018
– volume: C32
  start-page: 1
  year: 1992
  ident: 10.1016/j.jconrel.2018.08.042_bb0645
  article-title: 2-Hydroxyethyl methacrylate (HEMA)-chemical-properties and applications in biomedical fields
  publication-title: J. Macromol. Sci.-Rev. Macromol. Chem. Phys.
  doi: 10.1080/15321799208018377
– volume: 102
  start-page: 123
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0655
  article-title: Hydrogel-forming microneedle arrays: Potential for use in minimally-invasive lithium monitoring
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2016.03.009
– volume: 29
  start-page: 82
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0095
  article-title: Feasibility of microneedles for percutaneous absorption of insulin
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2006.05.011
– ident: 10.1016/j.jconrel.2018.08.042_bb0005
– volume: 24
  start-page: 106
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0605
  article-title: Poly-gamma-glutamic acid microneedles with a supporting structure design as a potential tool for transdermal delivery of insulin
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2015.06.021
– volume: 35
  start-page: 1242
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0545
  article-title: Processing difficulties and instability of carbohydrate microneedle arrays
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639040902882280
– ident: 10.1016/j.jconrel.2018.08.042_bb0440
  doi: 10.1088/1742-6596/34/1/187
– volume: 16
  start-page: 473
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0485
  article-title: Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/16/3/001
– volume: 51
  start-page: 2124
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0705
  article-title: A synthetic approach toward a self-regulated insulin delivery system
  publication-title: Angewandte Chemie-International Edition
  doi: 10.1002/anie.201106252
– volume: 35 (
  start-page: 6676
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0235
  article-title: Safety, acceptability and tolerability of uncoated and excipient-coated high density silicon micro-projection array patches in human subjects
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2017.10.021
– volume: 17
  start-page: 187
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0145
  article-title: Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety
  publication-title: Drug Delivery
  doi: 10.3109/10717541003667798
– volume: 14
  start-page: 1462
  year: 2004
  ident: 10.1016/j.jconrel.2018.08.042_bb0265
  article-title: Non-photolithographic pattern transfer for fabricating pen-shaped microneedle structures
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/14/11/005
– volume: Vol. 18
  start-page: 37
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0410
– volume: 13
  start-page: 435
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0800
  article-title: Intradermal microneedle delivery of insulin lispro achieves faster insulin absorption and insulin action than subcutaneous injection
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2010.0184
– volume: 5
  start-page: 397
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0290
  article-title: Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
  publication-title: Drug Delivery and Translational Research
  doi: 10.1007/s13346-015-0238-y
– volume: 2
  start-page: 197
  year: 2000
  ident: 10.1016/j.jconrel.2018.08.042_bb0430
  article-title: Hollow metallic micromachined needle arrays
  publication-title: Biomed. Microdevices
  doi: 10.1023/A:1009980412628
– volume: 96
  start-page: 1167
  year: 2008
  ident: 10.1016/j.jconrel.2018.08.042_bb0275
  article-title: Noninvasive neural prostheses using mobile and wireless EEG
  publication-title: Proceedings of the Leee
– volume: 65
  start-page: 152
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0115
  article-title: Modeling the human skin barrier - Towards a better understanding of dermal absorption
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2012.04.003
– volume: 161
  start-page: 933
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0180
  article-title: The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2012.05.030
– volume: 14
  start-page: 375
  year: 2007
  ident: 10.1016/j.jconrel.2018.08.042_bb0755
  article-title: Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines
  publication-title: Clin. Vaccine Immunol.
  doi: 10.1128/CVI.00387-06
– volume: 13
  start-page: 451
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0080
  article-title: Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects
  publication-title: Diabetes Technol. Ther.
  doi: 10.1089/dia.2010.0204
– volume: 33
  start-page: 2472
  year: 2000
  ident: 10.1016/j.jconrel.2018.08.042_bb0650
  article-title: Structure and morphology of freeze/thawed PVA hydrogels
  publication-title: Macromolecules
  doi: 10.1021/ma9907587
– volume: 54
  start-page: S41
  year: 2002
  ident: 10.1016/j.jconrel.2018.08.042_bb0100
  article-title: Skin structure and mode of action of vesicles
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/S0169-409X(02)00114-X
– volume: 19
  start-page: 406
  year: 2004
  ident: 10.1016/j.jconrel.2018.08.042_bb0375
  article-title: Study for the asepsis storage period of insulin in jection after seal removing
  publication-title: Journal of Nurses Training
– volume: 43
  start-page: 321
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0735
  article-title: Microneedling: A comprehensive review
  publication-title: Dermatol. Surg.
  doi: 10.1097/DSS.0000000000000924
– volume: 23
  start-page: 991
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0500
  article-title: Hypodermic-needle-like hollow polymer microneedle array: Fabrication and characterization
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2014.2307320
– volume: 127
  start-page: 119
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0780
  article-title: Insulin delivery systems combined with microneedle technology
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.03.011
– volume: 30
  start-page: 1099
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0110
  article-title: Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum
  publication-title: Pharm. Res.
  doi: 10.1007/s11095-012-0946-7
– volume: 6
  start-page: 191
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0620
  article-title: Hydrogel microneedle arrays for transdermal drug delivery
  publication-title: Nano-Micro Letters
  doi: 10.1007/BF03353783
– volume: 14
  start-page: 472
  year: 2005
  ident: 10.1016/j.jconrel.2018.08.042_bb0450
  article-title: Arrays of hollow out-of-plane microneedles for drug delivery
  publication-title: J. Microelectromech. Syst.
  doi: 10.1109/JMEMS.2005.844843
– volume: 106
  start-page: 48
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0660
  article-title: Swellable silk fibroin microneedles for transdermal drug delivery
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2017.07.178
– volume: 7
  start-page: 15408
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0175
  article-title: A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
  publication-title: RSC Adv.
  doi: 10.1039/C6RA26759A
– start-page: U1425
  year: 2006
  ident: 10.1016/j.jconrel.2018.08.042_bb0340
  article-title: Study of cross-linking reactions in negative-type thick-film resists
– volume: 104
  start-page: 1
  year: 2016
  ident: 10.1016/j.jconrel.2018.08.042_bb0740
  article-title: Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
  publication-title: Materials Science & Engineering R-Reports
  doi: 10.1016/j.mser.2016.03.001
– volume: 139
  start-page: 63
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0380
  article-title: Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2009.05.031
– volume: 14
  start-page: 459
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0395
  article-title: Faster pharmacokinetics and increased patient acceptance of intradermal insulin delivery using a single hollow microneedle in children and adolescents with type 1 diabetes
  publication-title: Pediatr. Diabetes
  doi: 10.1111/pedi.12031
– volume: 27
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0160
  article-title: A novel ultrafine needle (UN) for innocuous and efficient subcutaneous insulin delivery
  publication-title: Adv. Funct. Mater.
– volume: 24
  start-page: 48
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0105
  article-title: An ex vivo human skin model for studying skin barrier repair
  publication-title: Exp. Dermatol.
  doi: 10.1111/exd.12579
– volume: 31
  start-page: 1632
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0535
  article-title: Rapidly dissolving fibroin microneedles for transdermal drug delivery
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2011.06.010
– volume: 53
  start-page: 493
  year: 2000
  ident: 10.1016/j.jconrel.2018.08.042_bb0295
  article-title: Use of SU-8 photoresist for very high aspect ratio x-ray lithography
  publication-title: Microelectron. Eng.
  doi: 10.1016/S0167-9317(00)00363-4
– volume: 437
  start-page: 51
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0370
  article-title: Novel lyophilized hydrogel patches for convenient and effective administration of microneedle-mediated insulin delivery
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2012.07.035
– volume: 127
  start-page: 106
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0520
  article-title: Polymeric microneedles for transdermal protein delivery
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2018.01.015
– volume: 7
  start-page: 5067
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0600
  article-title: Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for in vivo insulin transdermal delivery
  publication-title: RSC Adv.
  doi: 10.1039/C6RA27476E
– volume: 3
  start-page: 555
  year: 2014
  ident: 10.1016/j.jconrel.2018.08.042_bb0255
  article-title: Nanocomposite-strengthened dissolving microneedles for improved transdermal delivery to human skin
  publication-title: Advanced Healthcare Materials
  doi: 10.1002/adhm.201300312
– volume: 23
  start-page: 1026
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0810
  article-title: Microarray patches: potentially useful delivery systems for long-acting nanosuspensions
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2017.10.013
– volume: 20
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0505
  article-title: Hollow agarose microneedle with silver coating for intradermal surface-enhanced Raman measurements: a skin-mimicking phantom study
  publication-title: J. Biomed. Opt.
  doi: 10.1117/1.JBO.20.6.061102
– volume: 265
  start-page: 2
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0215
  article-title: Formulation of hydrophobic peptides for skin delivery via coated microneedles
  publication-title: J. Control. Release
  doi: 10.1016/j.jconrel.2017.03.015
– volume: 11
  start-page: 1195
  year: 2009
  ident: 10.1016/j.jconrel.2018.08.042_bb0330
  article-title: Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery
  publication-title: Biomed. Microdevices
  doi: 10.1007/s10544-009-9337-1
– volume: 5
  start-page: 51934
  year: 2015
  ident: 10.1016/j.jconrel.2018.08.042_bb0025
  article-title: Biodegradable and conductive chitosan-graphene quantum dot nanocomposite microneedles for delivery of both small and large molecular weight therapeutics
  publication-title: RSC Adv.
  doi: 10.1039/C5RA04340A
– volume: 9
  start-page: 8952
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0185
  article-title: Dissolving polymer microneedle patches for rapid and efficient transdermal delivery of insulin to diabetic rats
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2013.06.029
– volume: 20
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0435
  article-title: Sharpening of hollow silicon microneedles to reduce skin penetration force
  publication-title: J. Micromech. Microeng.
  doi: 10.1088/0960-1317/20/4/045011
– ident: 10.1016/j.jconrel.2018.08.042_bb0310
  doi: 10.1088/1742-6596/34/1/030
– volume: 110
  start-page: 30
  year: 2018
  ident: 10.1016/j.jconrel.2018.08.042_bb0065
  article-title: Microneedles: A versatile strategy for transdermal delivery of biological molecules
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2017.12.027
– volume: 34
  start-page: 461
  year: 2010
  ident: 10.1016/j.jconrel.2018.08.042_bb0225
  article-title: Design and development of a biocompatible painless microneedle by the ion sputtering deposition method
  publication-title: Precision Engineering-Journal of the International Societies for Precision Engineering and Nanotechnology
– volume: 9
  start-page: 3704
  year: 2013
  ident: 10.1016/j.jconrel.2018.08.042_bb0665
  article-title: Transdermal delivery devices: Fabrication, mechanics and drug release from silk
  publication-title: Small
  doi: 10.1002/smll.201202075
– volume: 37
  start-page: 1387
  year: 2011
  ident: 10.1016/j.jconrel.2018.08.042_bb0570
  article-title: Two-layered dissolving microneedles for percutaneous delivery of sumatriptan in rats
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.3109/03639045.2011.576426
– volume: 80
  start-page: 187
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0595
  article-title: Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin
  publication-title: Materials Science & Engineering C-Materials for Biological Applications
  doi: 10.1016/j.msec.2017.05.143
– volume: 22
  start-page: 4879
  year: 2012
  ident: 10.1016/j.jconrel.2018.08.042_bb0385
  article-title: Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery
  publication-title: Adv. Funct. Mater.
  doi: 10.1002/adfm.201200864
– volume: 105
  start-page: 84
  year: 2017
  ident: 10.1016/j.jconrel.2018.08.042_bb0615
  article-title: Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice
  publication-title: J. Biomed. Mater. Res. A
  doi: 10.1002/jbm.a.35869
SSID ssj0005347
Score 2.5808496
SecondaryResourceType review_article
Snippet Microneedle technology relates to pharmacy, polymer chemistry and micromachining. Microneedle can effectively deliver insulin into systemic circulation across...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 173
SubjectTerms Diabetes
Glucose-responsive microneedle
Hydrogel
Insulin
Microneedle fabrication
pain
phase transition
Phase transition microneedle
polymers
Skin
subcutaneous injection
Title Preparation, properties and challenges of the microneedles-based insulin delivery system
URI https://dx.doi.org/10.1016/j.jconrel.2018.08.042
https://www.ncbi.nlm.nih.gov/pubmed/30189223
https://www.proquest.com/docview/2101271902
https://www.proquest.com/docview/2153624847
Volume 288
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LSyNBEG5EL15kfewa3ZUWxFM6mUfPTPdRRImKElAht6afYIiTkMchl_3tW5WZMXpQYY8zdEPRVVPf19NVXxNyBhDlXC4yZrSIGE-NZMJEBQtBxlprJzXHRuH7h7z3zG8H2WCDXDa9MFhWWef-KqevsnX9pluvZnfy8tJ9BLIi0jyTEJQRnvZgBzsvMMo7f9-VeaS8apnOBcPR6y6e7rAzhD3n1OMJRCxWSp48-QyfPuOfKxy6_kF2agJJLyobd8mGL_fIeb9SoF626dO6oWrWpue0v9amXu6TQX_qK7XvcdmmE_wTP0VJVapLR21zscqMjgMFZkhfsVyvBIAb-RlDwHO0Ll6nzo-wpGNJKy3oA_J8ffV02WP15QrMZlE8Z05boWNngxOWe5MZY0LKfSJFHlnYprhYOB_SxLtcu0JGwmtjRAKb18w7aWz6k2yWYMEhoS5PTR6kj422vDCx5jKJjQcy40ORhaJFeLOkytbK43gBxkg1JWZDVXtCoScUXozJkxbpvE2bVNIb300Qjb_UhxhSAA_fTT1t_Kvg-8JDE1368WKmEhRAK4A2fTkmAx7AAehb5FcVHG8WQwIVEjjY0f8bd0y28QkRMxG_yeZ8uvB_gArNzckq1k_I1sXNXe_hHy3YDLk
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VcoALKs8GKCwS9JRN7PXa3j30gIAqpQ9FIpVyW_YpNQpOFKeqcuFP8QeZjdcNHEolpF5trzWaGc986535BqH3kKKsLXhOtOIJYZkWhOukJN6LVCllhWKhUfj0rBics6_jfLyFfrW9MKGsMsb-Jqavo3W80o_a7M8vLvrfAKzwrMgFOGUSTntiZeWxW13Bvq0-OPoMRv5A6eGX0acBiaMFiMmTdEmsMlyl1njLDXM611r7jDkqeJEYAOk25db5jDpbKFuKhDulNaewdcudFdpk8N576D6DcBHGJvR-_lFXkrGmR7vgJIi3aRvqT3oT2OQuXDjySPmaOpTRmxLiTYB3nfgOd9CjiFjxx0Ypj9GWq56g_WFDeb3q4tGmg6vu4n083JBhr56i8XDhGnrxWdXF8_DrfxE4XLGqLDbtJJcazzwGKIp_hPrACjLq1NUkZFiLY7U8tm4aakhWuCGffobO70Tlz9F2BRLsImyLTBdeuFQrw0qdKiZoqh2gJ-fL3JcdxFqVShOpzsPEjalsa9omMlpCBkvIMImT0Q7qXS-bN1wfty3grb3kX04rIR_dtvRda18JH3Q4pVGVm13WkgbGtRJw2j-fyQF4MEAWHfSicY5riSFicwGg7-X_C_cWPRiMTk_kydHZ8Sv0MNwJ6Zry12h7ubh0e4DDlvrN2u8x-n7XH9pvXFVLaw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Preparation%2C+properties+and+challenges+of+the+microneedles-based+insulin+delivery+system&rft.jtitle=Journal+of+controlled+release&rft.au=Chen%2C+Xiang&rft.au=Wang%2C+Li&rft.au=Yu%2C+Haojie&rft.au=Li%2C+Chengjiang&rft.date=2018-10-28&rft.pub=Elsevier+B.V&rft.issn=0168-3659&rft.eissn=1873-4995&rft.volume=288&rft.spage=173&rft.epage=188&rft_id=info:doi/10.1016%2Fj.jconrel.2018.08.042&rft.externalDocID=S0168365918305169
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0168-3659&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0168-3659&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0168-3659&client=summon