Anti-angiogenic activity of heparin functionalised cerium oxide nanoparticles

• Published in: Biomaterials Vol. 34; no. 34; pp. 8808 - 8818
• Main Authors: Lord, Megan S, Tsoi, Bonny, Gunawan, Cindy, Teoh, Wey Yang, Amal, Rose, Whitelock, John M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2013
• Subjects: Advanced Basic Science; Angiogenesis; Angiogenesis Inhibitors - pharmacology; Cell Line, Tumor; Cell Proliferation - drug effects; Cell Survival; Cerium - chemistry; Cerium - pharmacology; Cerium oxide; Dentistry; Endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Heparin; Heparin - pharmacology; Humans; Lysosomes - drug effects; Lysosomes - metabolism; Nanoparticle; Nanoparticles - chemistry; Neovascularization, Pathologic - drug therapy; Propylamines; Reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction; Silanes - chemistry; Angiogenesis; Reactive oxygen species; Heparin; Cerium oxide; Nanoparticle; Endothelial cells

Abstract Cerium oxide nanoparticles (nanoceria) are widely reported to be non-cytotoxic and modulate intracellular reactive oxygen species (ROS). In this study, nanoceria ( dxRD  = 12 nm) were functionalised with either 130 or 880 molecules of unfractionated heparin using the organosilane linker, 3-...