Population Pharmacokinetics of Risperidone and Paliperidone in Schizophrenia: A Systematic Review

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 18; no. 5; p. 698
• Main Authors: Carrascosa-Arteaga, Ana, Nalda-Molina, Ricardo, Más-Serrano, Patricio, Ramon-Lopez, Amelia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.05.2025; MDPI
• Subjects: antipsychotic agents; Antipsychotics; Bibliographic data bases; Body mass index; Dopamine; Dosage and administration; Drug dosages; drug monitoring; Drug therapy; Health sciences; Libraries; Medical Subject Headings-MeSH; Metabolism; paliperidone palmitate; Pharmaceutical research; Pharmacokinetics; Physiological aspects; Plasma; Psychotropic drugs; Risperidone; Schizophrenia; Systematic Review; Spain; pharmacokinetics; schizophrenia; antipsychotic agents; paliperidone palmitate; drug monitoring; risperidone

Background: The primary treatment of schizophrenia is pharmacotherapy with antipsychotic agents, such as risperidone and paliperidone. Population pharmacokinetic (PopPK) modelling plays a crucial role in optimising therapy by predicting of plasma concentrations, therapeutic efficacy, and the risk of...