Comparative effects of glucose and xylose on blood pressure, gastric emptying and incretin hormones in healthy older subjects

• Published in: British journal of nutrition Vol. 105; no. 11; pp. 1644 - 1651
• Main Authors: Vanis, Lora, Hausken, Trygve, Gentilcore, Diana, Rigda, Rachael S., Rayner, Christopher K., Feinle-Bisset, Christine, Horowitz, Michael, Jones, Karen L.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.06.2011; CABI Pub
• Subjects: Aged; analysis; beverages; Biological and medical sciences; blood; blood glucose; Blood Glucose - analysis; Blood Glucose - drug effects; Blood pressure; Blood Pressure - drug effects; blood serum; Carbohydrates; Digestive system; Double-Blind Method; drug effects; Effects; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; gastric emptying; Gastric Emptying - drug effects; Gastric Inhibitory Polypeptide; Gastric Inhibitory Polypeptide - blood; Gastric Inhibitory Polypeptide - genetics; Gastric Inhibitory Polypeptide - metabolism; Gene Expression Regulation; Gene Expression Regulation - drug effects; genetics; glucagon-like peptide 1; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 1 - genetics; Glucagon-Like Peptide 1 - metabolism; Glucose; Glucose - pharmacology; Heart Rate; Heart Rate - drug effects; hormone secretion; Hormones; Human and Clinical Nutrition; Humans; hyperinsulinemia; hypotension; Incretins; Incretins - genetics; Incretins - metabolism; Insulin; Insulin - blood; Male; metabolism; Older people; pharmacology; secretin; small intestine; stomach; Sugar; ultrasonics; Vertebrates: anatomy and physiology, studies on body, several organs or systems; xylose; Xylose - pharmacology; Glucagon-like peptide-1; Postprandial hypotension; Ageing; Glucose-dependent insulinotropic peptide; Ultrasound; Insulin; Monosaccharides; Stomach; Incretin; Pancreatic hormone; Senescence; Healthy subject; Digestive system; Postprandial; Gastric emptying; Glucose; Glucagon like peptide 1; Xylose; Vertebrata; Gastrointestinal hormone; Mammalia; Ultrasound: Monosaccharides; Blood pressure; Hemodynamics

Postprandial hypotension is an important disorder for which current management is suboptimal. In healthy older subjects, oral and small-intestinal glucose administration decreases blood pressure (BP), and the magnitude of the reduction is dependent on the rate of glucose entry into the small intesti...