Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects - Soltys, Daniela T.; Pereira, Carolina P.M.; Rowies, Fernanda T.; Farfel, José M.; Grinberg, Lea T.; Suemoto, Claudia K.; Leite, Renata E.P.; Rodriguez, Roberta D.; Ericson, Nolan G.; Bielas, Jason H.; Souza-Pinto, Nadja C. (Neurobiology of aging, 2019)
Keywords: Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - pathology; Alzheimer's disease; Base excision repair; Brain - metabolism; DNA Repair - genetics; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism; Female; Gene Dosage; Humans; Male; Middle Aged; mtDNA depletion; mtDNA mutation; Mutation; Oxidative Stress - genetics; Temporal Lobe - metabolism; Uracil-DNA Glycosidase - metabolism; mtDNA mutation; mtDNA depletion; Base excision repair; Alzheimer's disease