Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 112; no. 40; pp. 12468 - 12473
• Main Authors: Sandiego, Christine M., Gallezot, Jean-Dominique, Pittman, Brian, Nabulsi, Nabeel, Lim, Keunpoong, Lin, Shu-Fei, Matuskey, David, Lee, Jae-Yun, O’Connor, Kevin C., Huang, Yiyun, Carson, Richard E., Hannestad, Jonas, Cosgrove, Kelly P.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.10.2015; National Acad Sciences
• Subjects: Acetamides - metabolism; Acetamides - pharmacokinetics; Adult; Binding sites; Biological Sciences; Biomarkers; Biomarkers - metabolism; Brain - immunology; Brain - metabolism; Carbon Radioisotopes - metabolism; Carbon Radioisotopes - pharmacokinetics; Cytokines - blood; Cytokines - metabolism; E coli; Endotoxins; Escherichia coli; Humans; Inflammation; Inflammation Mediators - blood; Inflammation Mediators - metabolism; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - immunology; Male; Microglia - immunology; Microglia - metabolism; Neurodegeneration; Positron-Emission Tomography - methods; Protein Binding; Pyridines - metabolism; Pyridines - pharmacokinetics; Radioactive tracers; Radiopharmaceuticals - metabolism; Radiopharmaceuticals - pharmacokinetics; Receptors, GABA - metabolism; Reproducibility of Results; Tomography; Young Adult; PBR28; cytokines; neuroinflammation; microglia; endotoxin

Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of theEscheric...