Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism

• Published in: Journal of hepatology Vol. 75; no. 2; pp. 400 - 413
• Main Authors: Li, Jie, Zhu, Xiaoyun, Zhang, Meihui, Zhang, Yanqiu, Ye, Shengtao, Leng, Yingrong, Yang, Ting, Kong, Lingyi, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2021; Elsevier Science Ltd
• Subjects: Acids; Animal models; Animals; Bile; Bile Acids and Salts - metabolism; Bile ducts; Cholangitis; Cholestasis; Cholestatic liver disease; Cholic acid; Chromatin; Disease Models, Animal; DNA microarrays; EGR-1; EGR-1 protein; Gallbladder diseases; Gene regulation; Hepatocytes; Homeostasis; Immunoprecipitation; Jaundice, Obstructive - etiology; Jaundice, Obstructive - genetics; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Biliary - complications; Liver diseases; LIX1L; LRH-1; Mice; MicroRNAs; miRNA; Patients; Post-transcription; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Therapeutic targets; EGR-1; LRH-1; Cholestatic liver disease; MicroRNAs; LIX1L

Cholestatic liver diseases comprise a variety of disorders of bile formation and/or flow which generally result in progressive hepatobiliary injury. Regulation of bile acid (BA) synthesis and homeostasis is a promising strategy for the treatment of cholestatic liver disease. Limb expression 1-like p...