Keeping the eIF2 alpha kinase Gcn2 in check

• Published in: Biochimica et biophysica acta Vol. 1843; no. 9; pp. 1948 - 1968
• Main Authors: Castilho, Beatriz A., Shanmugam, Renuka, Silva, Richard C., Ramesh, Rashmi, Himme, Benjamin M., Sattlegger, Evelyn
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014; Elsevier
• Subjects: Amino Acid Sequence; Animals; eIF-2 Kinase - chemistry; eIF-2 Kinase - metabolism; eIF2; Gcn1; Gcn2; Humans; Models, Biological; Molecular Sequence Data; Ribosome; Ribosomes - metabolism; RNA, Transfer - metabolism; Signal Transduction; Translational regulation; Uncharged tRNA; Viral Proteins - metabolism; Gcn2; Ribosome; Translational regulation; Gcn1; Uncharged tRNA; eIF2

The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest due to its involvement in a large array of crucial biological processes. Some of these are universally conserved from yeast to humans, such as coping with nutrient starvation and oxidative stress. In mammals...